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Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles
Research Center of Molecular Diagnostics & Therapy Moscow, Russia
Research Center of Molecular Diagnostics & Therapy Moscow, Russia
Research Center of Molecular Diagnostics & Therapy Moscow, Russia
Moscow State University Moscow, Russia
Moscow State University Moscow, Russia
Moscow State University Moscow, Russia
- 1 Research Center of Molecular Diagnostics & Therapy Moscow, Russia
- 2 Research Center of Molecular Diagnostics & Therapy Moscow, Russia
- 3 Research Center of Molecular Diagnostics & Therapy Moscow, Russia
- 4 Moscow State University Moscow, Russia
- 5 Moscow State University Moscow, Russia
- 6 Moscow State University Moscow, Russia
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Abstract
Inclusion of L-DOPA, the standard Parkinson’s disease medication, into polymeric particles (PLGA) results in optimization the drug metabolism and increasing its bioavailability, significantly increases of physical endurance, better coordination and lower anxiety in Wistar rats, when chronically administered nasally.
KeywordsNanopaticlsL-DOPANasal AdministrationParkinson’s Disease
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