Research ArticleOpen AccessGoogle Scholar indexed
The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability
Department of General, Visceral, Vascular and Thoracic Surgery, Division of Molecular Biology, Charité - Universit?tsmedizin Berlin, Berlin, Germany
Department of General, Visceral, Vascular and Thoracic Surgery, Division of Molecular Biology, Charité - Universit?tsmedizin Berlin, Berlin, Germany
- 1 Department of General, Visceral, Vascular and Thoracic Surgery, Division of Molecular Biology, Charité - Universit?tsmedizin Berlin, Berlin, Germany
- 2 Department of General, Visceral, Vascular and Thoracic Surgery, Division of Molecular Biology, Charité - Universit?tsmedizin Berlin, Berlin, Germany
Copy link · social · email
Abstract
Obesity is a serious health problem of our time. Dysfunction of adipogenesis, the differentiation of adipocytes, is a hallmark of obesity. Therefore here we investigate the role of the COP9 signalosome and of CHOP in the differentiation of LiSa-2 preadipocytes.
KeywordsCOP9 SignalosomeCHOPAdipogenesisCullin-RING Ubiquitin Ligase
- Li, X. et al. (2006) Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression. Biochem. Biophys. Res. Commun. 350, 1-6.
- Wei, N., Chamovitz, D.A. and Deng, X.W. (1994) Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.
- Deshaies, R.J. and Joazeiro, C.A. (2009) RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78, 399-434.
- Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611.
- Rogalla, S., Geier, C.F., Braumann, C., Ordemann, J., Müller, J.M. and Dubiel, W. (2010) in: 45th Congress of the European Society for Surgical Research - ESSR -, Vol. 45, pp. 17-23 (Cikirikcioglu, M., Ed.) MEDIMOND, Geneva, Switzerland.
- Braumann, C., Tangermann, J., Jacobi, C.A., Muller, J.M. and Dubiel, W. (2008) Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini Rev Med Chem 8, 421-428.
- Aggarwal, B.B. (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 30, 173-199.