Purpose of Review : Obesity is defined as an abnormal fat accumulation associated with disease development risk. The prevalence of obesity and non-communicable diseases (NCDs) continues to increase at a concerning pace. The modern lifestyle requires people to rely on processed foods because of their efficiency and low-cost, which are associated with obesity and NCDs. Vegetarian diet refers to the exclusion of meat, fish, seafood and can also exclude animal products such as dairy and eggs. Therefore, the purpose of this review is to explore vegetarianism as a potential solution for obesity and the development of non-communicable diseases. Recent Findings : Meat intake is also related to unhealthy food groups consumption, contributing to overall poor diet quality. In contrast, vegetarian diets are associated with higher satiety, resulting in less food intake, favoring weight reduction. Lowering the prevalence of NCDs should be a priority, and nutritional interventions are p ivotal to accomplish this goal. Summary : Vegetarian diets are associated with weight loss due to: fiber content, lower caloric density, microbiota regulation, and the release of gastrointestinal appetite-regulating hormones. Plant-based eating patterns have demonstrated an overall healthier diet and can be a potential solution for obesity and NCDs’ development.
Ritchie, H. and Roser, M. (2020) Obesity—Our World in Data. https://ourworldindata.org/obesity
WHO (2020) Obesity and Overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Popkin, B.M., Corvalan, C. and Grummer-Strawn, L.M. (2020) Dynamics of the Double Burden of Malnutrition and the Changing Nutrition Reality. The Lancet, 395, 65-74. https://doi.org/10.1016/S0140-6736(19)32497-3
WHO (2018) Noncommunicable Diseases. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
Huffman, S.L., Piwoz, E.G., Vosti, S.A. and Dewey, K.G. (2014) Babies, Soft Drinks and Snacks: A Concern in Low-and Middle-Income Countries? Maternal & Child Nutrition, 10, 562-574. https://doi.org/10.1111/mcn.12126
Dinu, M., Abbate, R., Gensini, G.F., Casini, A. and Sofi, F. (2017) Vegetarian, Vegan Diets and Multiple Health Outcomes: A Systematic Review with Meta-Analysis of Observational Studies. Critical Reviews in Food Science and Nutrition, 57, 3640-3649. https://doi.org/10.1080/10408398.2016.1138447
Mariotti, F. and Gardner, C.D. (2019) Dietary Protein and Amino Acids in Vegetarian Diets—A Review. Nutrients, 11, 2661. https://doi.org/10.3390/nu11112661
Myrmel, L.S., Fauske, K.R., Fjære, E., Bernhard, A., Liisberg, U., Hasselberg, A.E., et al. (2019) The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during ad Libitum Feeding and Energy Restriction in Already Obese Mice. Nutrients, 11, 1153. https://doi.org/10.3390/nu11051153
Fogelholm, M., Kanerva, N. and Männistä, S. (2015) Association between Red and Processed Meat Consumption and Chronic Diseases: The Confounding Role of Other Dietary Factors. European Journal of Clinical Nutrition, 69, 1060-1065. https://doi.org/10.1038/ejcn.2015.63
Vergnaud, A.-C., Norat, T., Romaguera, D., Mouw, T., May, A.M., Travier, N., et al. (2010) Meat Consumption and Prospective Weight Change in Participants of the EPIC-PANACEA Study. The American Journal of Clinical Nutrition, 92, 398-407. https://doi.org/10.3945/ajcn.2009.28713
Chai, W., Morimoto, Y., Cooney, R.V., Franke, A.A., Shvetsov, Y.B., Le Marchand, L., et al. (2017) Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study. Journal of the American College of Nutrition, 36, 378-385. https://doi.org/10.1080/07315724.2017.1318317
Salter, A.M. (2018) The Effects of Meat Consumption on Global Health. Revue Scientifique et Technique, 37, 47-55. https://doi.org/10.20506/rst.37.1.2739
Serra-Majem, L., Tomaino, L., Dernini, S., Berry, E.M., Lairon, D., de la Cruz, J.N., et al. (2020) Updating the Mediterranean Diet Pyramid towards Sustainability: Focus on Environmental Concerns. International Journal of Environmental Research and Public Health, 17, 8758. https://doi.org/10.3390/ijerph17238758
Medawar, E., Huhn, S., Villringer, A. and Veronica Witte, A. (2019) The Effects of Plant-Based Diets on the Body and the Brain: A Systematic Review. Translational Psychiatry, 9, Article No. 226. https://doi.org/10.1038/s41398-019-0552-0
Najjar, R.S. and Feresin, R.G. (2019) Plant-Based Diets in the Reduction of Body Fat: Physiological Effects and Biochemical Insights. Nutrients, 11, 2712. https://doi.org/10.3390/nu11112712
Huang, R.-Y., Huang, C.-C., Hu, F.B. and Chavarro, J.E. (2016) Vegetarian Diets and Weight Reduction: A Meta-Analysis of Randomized Controlled Trials. Journal of General Internal Medicine, 31, 109-116. https://doi.org/10.1007/s11606-015-3390-7
Gill, S.K., Rossi, M., Bajka, B. and Whelan, K. (2020) Dietary Fibre in Gastrointestinal Health and Disease. Nature Reviews Gastroenterology & Hepatology, 18, 101-116. https://doi.org/10.1038/s41575-020-00375-4
Turner-McGrievy, G., Mandes, T. and Crimarco, A. (2017) A Plant-Based Diet for Overweight and Obesity Prevention and Treatment. Journal of Geriatric Cardiology, 14, 369-374.
Campbell, E.K., Fidahusain, M. and Campbell II, T.M. (2019) Evaluation of an Eight-Week Whole-Food Plant-Based Lifestyle Modification Program. Nutrients, 11, 2068. https://doi.org/10.3390/nu11092068
Moore, W.J., McGrievy, M.E. and Turner-McGrievy, G.M. (2015) Dietary Adherence and Acceptability of Five Different Diets, Including Vegan and Vegetarian Diets, for Weight Loss: The New DIETs Study. Eating Behaviors, 19, 33-38. https://doi.org/10.1016/j.eatbeh.2015.06.011
Thom, G. and Lean, M. (2017) Is There an Optimal Diet for Weight Management and Metabolic Health? Gastroenterology, 152, 1739-1751. https://doi.org/10.1053/j.gastro.2017.01.056
American Diabetes Association (ADA) (2014) Dietetics A of N and Choose Your Foods, Food Lists for Weight Management. USA, 1-64.
Klementova, M., Thieme, L., Haluzik, M., Pavlovicova, R., Hill, M., Pelikanova, T., et al. (2019) A Plant-Based Meal Increases Gastrointestinal Hormones and Satiety More than an Energy-and Macronutrient-Matched Processed-Meat Meal in T2D, Obese, and Healthy Men: A Three-Group Randomized Crossover Study. Nutrients, 11, 1-10. https://doi.org/10.3390/nu11010157
Zhubi-Bakija, F., Bajraktari, G., Bytyçi, I., Mikhailidis, D.P., Henein, M.Y., Latkovskis, G., et al. (2021) The Impact of Type of Dietary Protein, Animal versus Vegetable, in Modifying Cardiometabolic Risk Factors: A Position Paper from the International Lipid Expert Panel (ILEP). Clinical Nutrition, 40, 255-276. https://doi.org/10.1016/j.clnu.2020.05.017
WHO (2017) Cardiovascular Diseases. WHO, Geneva.
Glenn, A.J., Viguiliouk, E., Seider, M., Boucher, B.A., Khan, T.A., Blanco Mejia, S., et al. (2019) Relation of Vegetarian Dietary Patterns with Major Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Frontiers in Nutrition, 6. https://doi.org/10.3389/fnut.2019.00080
Bechthold, A., Boeing, H., Schwedhelm, C., Hoffmann, G., Knüppel, S., Iqbal, K., et al. (2019) Food Groups and Risk of Coronary Heart Disease, Stroke and Heart Failure: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Critical Reviews in Food Science and Nutrition, 59, 1071-1090. https://doi.org/10.1080/10408398.2017.1392288
Sacks, F.M., Lichtenstein, A.H., Wu, J.H.Y., Appel, L.J., Creager, M.A., Kris-Etherton, P.M., et al. (2017) Dietary Fats and Cardiovascular Disease: A Presidential Advisory from the American Heart Association. Circulation, 136, e1-e23. https://doi.org/10.1161/CIR.0000000000000510
Sofi, F., Dinu, M., Pagliai, G., Cesari, F., Gori, A.M., Sereni, A., et al. (2018) Low-Calorie Vegetarian versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile. Circulation, 137, 1103-1113. https://doi.org/10.1161/CIRCULATIONAHA.117.030088
Saeedi, P., Petersohn, I., Salpea, P., Bright, D. and Williams, R. (2019) Global and Regional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th Edition. Diabetes Research and Clinical Practice, 157, Article ID: 107843. https://doi.org/10.1016/j.diabres.2019.107843
Tonstad, S. and Clifton, P. (2017) 20-Vegetarian Diets and the Risk of Type 2 Diabetes. In: Vegetarian and Plant-Based Diets in Health and Disease Prevention, Academic Press, 355-367. https://doi.org/10.1016/B978-0-12-803968-7.00020-4
Cho, N.H., Shaw, J.E., Karuranga, S., Huang, Y., da Rocha Fernandes, J.D., Ohlrogge, A.W., et al. (2018) IDF Diabetes Atlas: Global Estimates of Diabetes Prevalence for 2017 and Projections for 2045. Diabetes Research and Clinical Practice, 138, 271-281. https://doi.org/10.1016/j.diabres.2018.02.023
Chiu, T.H.T., Pan, W.H., Lin, M.N. and Lin, C.L. (2018) Vegetarian Diet, Change in Dietary Patterns, and Diabetes Risk: A Prospective Study. Nutrition & Diabetes, 8, Article No. 12. https://doi.org/10.1038/s41387-018-0022-4
Papier, K., Appleby, P.N., Fensom, G.K., Knuppel, A., Perez-Cornago, A., Schmidt, J.A., et al. (2019) Vegetarian Diets and Risk of Hospitalisation or Death with Diabetes in British Adults: Results from the EPIC-Oxford Study. Nutrition & Diabetes, 9, Article No. 7. https://doi.org/10.1038/s41387-019-0074-0
Vang, A., Singh, P.N., Lee, J.W., Haddad, E.H. and Brinegar, C.H. (2008) Meats, Processed Meats, Obesity, Weight Gain and Occurrence of Diabetes among Adults: Findings from Adventist Health Studies. Annals of Nutrition and Metabolism, 52, 96-104. https://doi.org/10.1159/000121365
Bikbov, B., Purcell, C.A., Levey, A.S., Smith, M., Abdoli, A., Abebe, M., et al. (2020) Global, Regional, and National Burden of Chronic Kidney Disease, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet, 395, 709-733. https://doi.org/10.1016/S0140-6736(20)30045-3
Watanabe, S. (2017) Low-Protein Diet for the Prevention of Renal Failure. Proceedings of the Japan Academy, Series B, 93, 1-9. https://doi.org/10.2183/pjab.93.001
Lees, J.S. and Mark, P.B. (2020) Fruit for Thought: Lifestyle Interventions to Reduce the Risk of Future Chronic Kidney Disease. Nephrology Dialysis Transplantation, gfaa266, 1-3. https://doi.org/10.1093/ndt/gfaa266
Bach, K.E., Kelly, J.T., Campbell, K.L., Palmer, S.C., Khalesi, S. and Strippoli, G.F.M. (2019) Healthy Dietary Patterns and Incidence of CKD: A Meta-Analysis of Cohort Studies. Clinical Journal of the American Society of Nephrology, 14, 1441-1449. https://doi.org/10.2215/CJN.00530119
Chauveau, P., Koppe, L., Combe, C., Lasseur, C., Trolonge, S. and Aparicio, M. (2019) Vegetarian Diets and Chronic Kidney Disease. Nephrology Dialysis Transplantation, 34, 199-207. https://doi.org/10.1093/ndt/gfy164
Yuzbashian, E., Asghari, G., Mirmiran, P., Hosseini, F.S. and Azizi, F. (2015) Associations of Dietary Macronutrients with Glomerular Filtration Rate and Kidney Dysfunction: Tehran Lipid and Glucose Study. Journal of Nephrology, 28, 173-180. https://doi.org/10.1007/s40620-014-0095-7
Institute of Medicine (2005) Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). 1-1331.
Sobiecki, J.G., Appleby, P.N., Bradbury, K.E. and Key, T.J. (2016) High Compliance with Dietary Recommendations in a Cohort of Meat Eaters, Fish Eaters, Vegetarians, and Vegans: Results from the European Prospective Investigation into Cancer and Nutrition-Oxford Study. Nutrition Research, 36, 464-477. https://doi.org/10.1016/j.nutres.2015.12.016
Gardner, C.D., Hartle, J.C., Garrett, R.D., Offringa, L.C. and Wasserman, A.S. (2019) Maximizing the Intersection of Human Health and the Health of the Environment with Regard to the Amount and Type of Protein Produced and Consumed in the United States. Nutrition Reviews, 77, 197-215. https://doi.org/10.1093/nutrit/nuy073
Young, V.R. and Pellett, P.L. (2018) Plant Proteins in Relation to Human and Amino Acid Nutrition. The American Journal of Clinical Nutrition, 59, 1203S-1212S. https://doi.org/10.1093/ajcn/59.5.1203S
David, L.A., Maurice, C.F., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., et al. (2014) Diet Rapidly and Reproducibly Alters the Human Gut Microbiome. Nature, 505, 559-563. https://doi.org/10.1038/nature12820
Shen, T.-C.D. (2017) Diet and Gut Microbiota in Health and Disease. Nestle Nutrition Institute Workshop Series, 88, 117-126. https://doi.org/10.1159/000455220
Koeth, R.A., Wang, Z., Levison, B.S., Buffa, J.A., Org, E., Sheehy, B.T., et al. (2013) Intestinal Microbiota Metabolism of L-Carnitine, a Nutrient in Red Meat, Promotes Atherosclerosis. Nature Medicine, 19, 576-585. https://doi.org/10.1038/nm.3145
Liu, T.X., Niu, H.T. and Zhang, S.Y. (2015) Intestinal Microbiota Metabolism and Atherosclerosis. Chinese Medical Journal (Engl), 128, 2805-2811. https://doi.org/10.4103/0366-6999.167362
Agnoli, C., Baroni, L., Bertini, I., Ciappellano, S., Fabbri, A., Papa, M., et al. (2017) Position Paper on Vegetarian Diets from the Working Group of the Italian Society of Human Nutrition. Nutrition, Metabolism and Cardiovascular Diseases, 27, 1037-1052. https://doi.org/10.1016/j.numecd.2017.10.020
Haider, L.M., Schwingshackl, L., Hoffmann, G. and Ekmekcioglu, C. (2018) The Effect of Vegetarian Diets on Iron Status in Adults: A Systematic Review and Meta-Analysis. Critical Reviews in Food Science and Nutrition, 58, 1359-1374. https://doi.org/10.1080/10408398.2016.1259210
Melina, V., Craig, W. and Levin, S. (2016) Position of the Academy of Nutrition and Dietetics: Vegetarian Diets. Journal of the Academy of Nutrition and Dietetics, 116, 1970-1980. https://doi.org/10.1016/j.jand.2016.09.025
Rizzo, G., Laganà, A.S., Rapisarda, A.M.C., La Ferrera, G.M.G., Buscema, M., Rossetti, P., et al. (2016) Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients, 8, 767. https://doi.org/10.3390/nu8120767
Del Bo, C., Riso, P., Gardana, C., Brusamolino, A., Battezzati, A. and Ciappellano, S. (2019) Effect of Two Different Sublingual Dosages of Vitamin B 12 on Cobalamin Nutritional Status in Vegans and Vegetarians with a Marginal Deficiency: A Randomized Controlled Trial. Clinical Nutrition, 38, 575-583. https://doi.org/10.1016/j.clnu.2018.02.008
Foster, M., Chu, A., Petocz, P. and Samman, S. (2013) Effect of Vegetarian Diets on Zinc Status: A Systematic Review and Meta-Analysis of Studies in Humans. Journal of the Science of Food and Agriculture, 93, 2362-2371. https://doi.org/10.1002/jsfa.6179