Wild Nutrition’s Food-Grown ® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind, Randomised, Placebo-Controlled Study
- 1 School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia
- 2 RDC Clinical, Brisbane, Australia
- 3 RDC Clinical, Brisbane, Australia
- 4 RDC Clinical, Brisbane, Australia
Abstract
Background : Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown ® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods : Eighty participants were randomly assigned to receive either 80 mg of Food-Grown ® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. Participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results : Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total Pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion : Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being.
- Blancquaert, L., Vervaet, C. and Derave, W. (2019) Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients , 11, Article 1663. https://doi.org/10.3390/nu11071663
- Swaminathan, R. (2003) Magnesium Metabolism and Its Disorders. Clinical Bi o chemist Reviews , 24, 47-66.
- Noronha, J.L. and Matuschak, G.M. (2002) Magnesium in Critical Illness: Metabolism, Assessment, and Treatment. Intensive Care Medicine , 28, 667-679. https://doi.org/10.1007/s00134-002-1281-y
- de Baaij, J.H., Hoenderop, J.G. and Bindels, R.J. (2015) Magnesium in Man: Implications for Health and Disease. Physiol ogical Rev iews , 95, 1-46. https://doi.org/10.1152/physrev.00012.2014
- Volpe, S.L. (2012) Magnesium. In: Erdman, J.W., Macdonald, I.A., Zeisel, S.H., Eds., Present Knowledge in Nutrition , Ames, 459-474.
- Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes (1997) Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press.
- Simonelli, G., Marshall, N.S., Grillakis, A., et al . (2018) Sleep Health Epidemiology in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis of the Prevalence of Poor Sleep Quality and Sleep Duration. Sleep Health , 4, 239-250. https://doi.org/10.1016/j.sleh.2018.03.001
- Cappuccio, F.P., D’Elia, L., Strazzullo, P., et al . (2010) Sleep Duration and All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies. Sleep , 33, 585-592. https://doi.org/10.1093/sleep/33.5.585
- Gallicchio, L. and Kalesan, B. (2009) Sleep Duration and Mortality: A Systematic Review and Meta-Analysis. J ournal of Sleep Res earch , 18, 148-158. https://doi.org/10.1111/j.1365-2869.2008.00732.x
- Zhang, Y., Chen, C., et al . (2022) Association of Magnesium Intake with Sleep Duration and Sleep Quality: Findings from the CARDIA Study. Sleep , 45, zsab276. https://doi.org/10.1093/sleep/zsab276
- Cao, Y., Zhen, S., Taylor, A.W., et al . (2018) Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. Nutrients , 10, Article 1354. https://doi.org/10.3390/nu10101354
- Nielsen, F.H. and Johnson, L.K. (2010) Magnesium Supplementation Improves Indicators of Low Magnesium Status and Inflammatory Stress in Adults Older than 51 Years with Poor Quality Sleep. T he Federation of American Societies for Exper i mental Biology , 24, 325.8. https://doi.org/10.1096/fasebj.24.1_supplement.325.8