Effects of Acetic Acid Bacteria ( Gluconacetobacter hansenii GK-1) on Fatigue Induced by Temporary Mental Stress: A Randomized, Double-Blind, Placebo-Controlled Study — Oak Academic Publishing
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Effects of Acetic Acid Bacteria ( Gluconacetobacter hansenii GK-1) on Fatigue Induced by Temporary Mental Stress: A Randomized, Double-Blind, Placebo-Controlled Study
R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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R&D Division, Kewpie Corporation, Tokyo, Japan
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Faculty of Education, Hokkaido University of Education, Sapporo, Japan
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Miura Medical Clinic, Osaka, Japan
1 R&D Division, Kewpie Corporation, Tokyo, Japan
2 R&D Division, Kewpie Corporation, Tokyo, Japan
3 R&D Division, Kewpie Corporation, Tokyo, Japan
4 R&D Division, Kewpie Corporation, Tokyo, Japan
5 R&D Division, Kewpie Corporation, Tokyo, Japan
6 R&D Division, Kewpie Corporation, Tokyo, Japan
7 R&D Division, Kewpie Corporation, Tokyo, Japan
8 Faculty of Education, Hokkaido University of Education, Sapporo, Japan
Objective: This study assessed the effects of consuming acetic acid bacteria ( Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placebo-controlled, parallel-group study included 100 healthy male and female adults aged 20 - 64 years. Participants consumed either the G . hansenii GK-1 supplement (9 × 10⁹ cells/day) or a placebo daily for 12 weeks. The impact of temporary mental stress on fatigue in G . hansenii GK-1 was assessed using a Visual Analog Scale (VAS) before the study began and after 12 weeks of supplementation. Results: Subjective fatigue measured by Visual Analog Scale (VAS) showed a significant decrease in fatigue induced by temporary mental stress after 12 weeks of consumption in the G . hansenii GK-1 group compared with the placebo group. No adverse events were attributed to G . hansenii GK-1. These findings confirm that continuous oral ingestion of G . hansenii GK-1 by healthy Japanese adults reduces feelings of fatigue caused by temporary mental stress.
KeywordsAcetic Acid BacteriaGluconacetobacter hansenii GK-1FatigueTemporary Mental StressDouble-Blind Study
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