Carrot is a root vegetable with carotenoids, flavonoids, polyacetylenes, vitamins, and minerals, all of which possess numerous nutritional and health benefits. Besides lending truth to the old adage that carrots are good for eyes, carotenoids, polyphenols and vitamins present in carrot act as antioxidants, anticarcinogens, and immunoenhancers. Anti-diabetic, cholesterol and cardiovascular disease lowering, anti-hypertensive, hepatoprotective, renoprotective, and wound healing benefits of carrot have also been reported. The cardio- and hepatoprotective, anti-bacterial, anti-fungal, anti-inflammatory, and analgesic effects of carrot seed extracts are also noteworthy. All are discussed in this review article.
Simon, P.W. (2000) Domestication, Historical Development and Modern Breeding of Carrot. Plant Breeding Reviews, 19, 157-190.
Dias, J.S. (2012) Major Classes of Phytonutriceuticals in Vegetables and Health Benefits: A Review. Journal of Nutritional Therapeutics, 1, 31-62.
Dias, J.S. (2012) Nutritional Quality and Health Benefits of Vegetables: A Review. Food and Nutrition Sciences, 3, 1354-1374. http://dx.doi.org/10.4236/fns.2012.310179
Sun, T., Simon, P.W. and Tamumuhardjo, S.A. (2009) Antioxidant Phytochemicals and Antioxidant Capacity of Biofortified Carrots (Daucus carota L.) of Various Colors. Journal of Agricultural and Food Chemistry, 57, 4142-4147. http://dx.doi.org/10.1021/jf9001044
Van het Hof, K.H., West, C.E., Weststrate, J.A. and Hautvast, J.G. (2000) Dietary Factors That Affect the Bioavailability of Carotenoids. J. Nutr., 130, 503-506.
Ching, L.S. and Mohamed, S. (2001) Alpha-Tocopherol Content of 62 Edible Tropical Plants. Journal of Agricultural and Food Chemistry, 49, 3101-3105. http://dx.doi.org/10.1021/jf000891u
Lila, M.A. (2004) Anthocyanins and Human Health: An in Vitro Investigative Approach. Journal of Biomedicine and Biotechnology, No. 5, 306-313. http://dx.doi.org/10.1155/S111072430440401X
Horbowicz, M., Kosson, R., Grzesiuk, A. and Bski, H.D. (2008) Anthocyanins of Fruits and Vegetables—Their Occurrence Analysis and Role in Human Nutrition. Vegetable Crops Research Bulletin, 68, 5-22.
Zhang, D. and Hamauzu, Y. (2004) Phenolic Compounds and Their Antioxidant Properties in Different Tissues of Carrots (Daucus carota L.). Journal of Food, Agriculture and Environment (JFAE), 2, 95-100.
Gon?alves, E.M., Pinheiro, J., Abreu, M. and Silva, C.L. (2010) Carrot (Daucus carota L.) Peroxidase Inactivation, Phenolic Content and Physical Changes Kinetics Due to Blanching. Journal of Food Engineering, 97, 574-581. http://dx.doi.org/10.1016/j.jfoodeng.2009.12.005
Lund, E.D. and White, J.M. (1990) Polyacetylenes in Normal and Waterstressed “Orlando Gold” Carrots (Daucus carota). Journal of the Science of Food and Agriculture, 51, 507-516. http://dx.doi.org/10.1002/jsfa.2740510407
Hansen, L., Hammershoy, O. and Boll, P.M. (1986) Allergic Contact Dermatitis from Falcarinol Isolated from Schaffera arboricola. Contact Dermatitis, 14, 91-93. http://dx.doi.org/10.1111/j.1600-0536.1986.tb01167.x
Fu, H.W., Zhang, L., Yi, T., Feng, Y.L. and Tian, J. (2010) Two New Guaniane-Type Sesquiterpenoids from the Fruits of Daucus carota L. Fitoterapia, 81, 443-446. http://dx.doi.org/10.1016/j.fitote.2009.12.008
Czepa, A. and Hofmann, T. (2003) Structural and Sensory Characterization of Compounds Contributing to the Bitter Off-Taste of Carrots (Daucus carota L.) and Carrot Puree. Journal of Agricultural and Food Chemistry, 51, 3865-3872. http://dx.doi.org/10.1021/jf034085+
Acharya, U.R., Mishra, M., Patro, J. and Panda, M.K. (2008) Effect of Vitamins C and E on Spermatogenesis in Mice Exposed to Cadmium. Reproductive Toxicology, 25, 84-88. http://dx.doi.org/10.1016/j.reprotox.2007.10.004
Guerrera, M.P., Volpe, S.L. and Mao, J.J. (2009) Therapeutic Uses of Magnesium. American Family Physician, 80, 157-162.
Bartlett, H.E. and Eperjesi, F. (2008) Nutritional Supplementation for Type 2 Diabetes: A Systematic Review. Ophthalmic and Physiological Optics, 28, 503-523. http://dx.doi.org/10.1111/j.1475-1313.2008.00595.x
Kim, D.J., Xun, P., Liu, K., Loria, C., Yokota, K., Jacobs Jr., D.R. and He, K. (2010) Magnesium Intake in Relation to System Inflammation, Insulin Resistance, and the Incidence of Diabetes. Diabetes Care, 33, 2604-2610. http://dx.doi.org/10.2337/dc10-0994
Zaini, R., Clench, M.R. and Maitre, C.L. (2011) Bioactive Chemicals from Carrot (Daucus carota) Juice Extracts for the Treatment of Leukemia. Journal of Medicinal Food, 14, 1303-1312. http://dx.doi.org/10.1089/jmf.2010.0284
Darroudi, F., Targa, H. and Natarajan, A.T. (1988) Influence of Dietary Carrot on Cytostatic Drug Activity of Cyclophosphamide and Its Main Directly Acting Metabolite: Induction of Sister-Chromatid Exchanges in Normal Human Lymphocytes, Chinese Hamster Ovary Cells, and Their DNA Repair-Deficient Cell Lines. Mutation Research, 198, 327-335. http://dx.doi.org/10.1016/0027-5107(88)90010-3
Larsen, M.K., Christensen, L.P., Vach, W., Hoitinga, R.J. and Brant, K. (2005) Inhibitory Effects of Feeding with Carrots or (?)-Falcarinol on Development of Azoxymethame-Induced Preneoplastic Lesions in the Rat Colon. Journal of Agricultural and Food Chemistry, 53, 1823-1827. http://dx.doi.org/10.1021/jf048519s
Purup, S., Larsen, E. and Christesen, L.P. (2009) Differential Effects of Falcarinol and Related Aliphatic C17-Polyacety-lenes on Intestinal Cell Proliferation. Journal of Agricultural and Food Chemistry, 57, 8290-8296. http://dx.doi.org/10.1021/jf901503a
Matsunaga, H., Katano, M., Yamanoto, H., Fujito, H. and Takata, M.M. (1990) Cytotoxic Activity of Polyacetylene Compouds in Panax ginseng C.A. Meyer. Chemical and Pharmaceutical Bulletin, 38, 3480-3482. http://dx.doi.org/10.1248/cpb.38.3480
Saita, T., Katano, M., Matsunaga, H., Yamamsoto, H., Fujito, H. and Mori, M. (1993) The First Specific Antibody against Cytotoxic Polyacetylenic Alcohol, Panaxysol. Chemical and Pharmaceutical Bulletin, 41, 549-552. http://dx.doi.org/10.1248/cpb.41.549
Ekam, V.S., Udosen, E.O. and Chighu, A.E. (2006) Comparative Effect of Carotenoid Complex from Goldenneo-Life Dynamite and Carrot Extracted Carotenoids on Immune Parameters in Albino Wistar Rats. Nigerian Journal of Physiological Sciences, 21, 1-4.
Swamy, K.R., Nath, P. and Ahuja, K.G. (2014) Vegetables for Human Nutrition and Health. In: Nath, P., Ed., The Basics of Human Civilization-Food, Agriculture and Humanity, Volume-II-Food, Prem Nath Agricultural Science Foundation (PNASF), Bangalore & New India Publishing Agency (NIPA), New Delhi, 145-198.
Pisani, P., Berrino, F., Macaluso, M., Pastorino, U., Crosignani, P. and Baldasseroni, A. (1986) Carrots, Green Vegetables and Lung Cancer: A Case-Control Study. International Journal of Epidemiology, 15, 463-468. http://dx.doi.org/10.1093/ije/15.4.463
Wu, K., Erdman Jr., J.W., Schwartz, S.J., Platz, E.A., Leitzmann, M., Clinton, S.K., DeGroff, V., Willett, W.C. and Giovannucci, E. (2004) Plasma and Dietary Carotenoids, and the Risk of Prostate Cancer: A Nested Case-Control Study. Cancer Epidemiology Biomarkers & Prevention, 13, 260-269. http://dx.doi.org/10.1158/1055-9965.EPI-03-0012
Hung, R.J., Zhang, Z.F., Rao, J.Y., Pannack, A., Reuter, V.E., Heber, D. and Lu, Q.Y. (2006) Protective Effects of Plasma Carotenoids on the Risk of Bladder Cancer. Journal of Urology, 176, 1192-1197. http://dx.doi.org/10.1016/j.juro.2006.04.030
Brazionis, L., Rowley, K., Itsiopoulos, C. and O’Dea, K. (2009) Plasma Carotenoids and Diabetic Retinopathy. The British Journal of Nutrition, 101, 270-277. http://dx.doi.org/10.1017/S0007114508006545
USDHHS (US Department of Health and Human Services) and USDA (US Department of Agriculture) (2010) Dietary Guidelines for Americans. 7th Edition, US Government Printing Office, Washington DC.
Coyne, T., Ibiebele, T.I., Baade, P.D., Dobson, A., McClintock, C., Dunn, S., Leonard, D. and Shaw, J. (2005) Diabetes Mellitus and Serum Carotenoids: Findings of a Population-Based Study in Queensland, Australia. The American Journal of Clinical Nutrition, 82, 685-693.
Chau, C.F., Chen, C.H. and Lee, M.H. (2004) Comparison of the Characteristics, Functional Properties, and in Vitro Hypoglycemic Effects of Various Carrot Insoluble Fiber-Rich Fractions. Lebensmittel-Wissenshaff und Technologie, 37, 155-160. http://dx.doi.org/10.1016/j.lwt.2003.08.001
Saura-Calixto, F. and Go?i, I. (2006) Antioxidant Capacity of the Spanish Meditarrean Diet. Food Chemistry, 94, 442-447. http://dx.doi.org/10.1016/j.foodchem.2004.11.033
Saura-Calixto, F., Serrano, J. and Go?i, I. (2007) Intake and Bioaccessibility of Total Polyphenols in a Whole Diet. Food Chemistry, 101, 492-501. http://dx.doi.org/10.1016/j.foodchem.2006.02.006
Harold, R., Reeves, R., Blze, M., Guthrie, R. and Guthrie, D. (1985) Effect of Dietary Fiber in Insulin-Dependent Diabetics: Insulin Requirements and Serum Lipids. Journal of the American Dietetic Association, 85, 1455-1461.
Poudyal, H., Panchal, S. and Brown, L. (2010) Comparison of Purple Carrot Juice and β-Carotene in a High-Carbohydrate, High-Fat Diet-Fed Rat Model of the Metabolic Syndrome. British Journal of Nutrition, 104, 1322-1332. http://dx.doi.org/10.1017/S0007114510002308
Nicolle, C., Cardinault, N., Aprikian, O., Busserolles, J., Grolier, P., Rock, E., Demigné, C., Mazur, A., Scalbert, A., Amouroux, P. and Rémésy, C. (2003) Effect of Carrot Intake on Cholesterol Metabolism and on Antioxidant Status in Cholesterol-Fed Rat. European Journal of Nutrition, 42, 254-261. http://dx.doi.org/10.1007/s00394-003-0419-1
Gramenzi, A., Gentile, A., Fasoli, M., Negri, E., Parazzini, F. and La Vecchia, C. (1990) Association between Certain Foods and Risk of Acute Myocardial Infarction in Women. BMJ, 300, 771-773. http://dx.doi.org/10.1136/bmj.300.6727.771
Griep, L.M., Verschuren, W.M., Kromhout, D., Ocké, M.C. and Geleijnse, J.M. (2011) Colors of Fruit and Vegetables and 10-Year Incidence of CHD. British Journal of Nutrition, 106, 1562-1569. http://dx.doi.org/10.1017/S0007114511001942
Gilani, A.H., Shaheeri, F., Saeed, S.A., Bibi, S., Irfamillah-Sadiq, M. and Faiz, S. (2000) Hypotensive Action of Coumarin Glycoside from Daucus carot. Phytomedicine, 7, 423-426. http://dx.doi.org/10.1016/S0944-7113(00)80064-1
Bishayee, A., Sarkar, A. and Chatterjee, M. (1995) Hepatoprotective Activity of Carrot (Daucus carota L.) against Carbon Tetrachoride Intoxication in Mouse Liver. Journal of Ethnopharmacology, 47, 69-74. http://dx.doi.org/10.1016/0378-8741(95)01254-B
Mills, J.P., Simon, P.W. and Tanumihardjo, S.A. (2008) Biofortified Carrot Intake Enhances Liver Antioxidant Capacity and Vitamin A Status in Mongolian Gerbils. Journal of Nutrition, 138, 1692-1698.
Mital, P.R., Laxman, P.J. and Ramesshvar, P.K. (2011) Protective Effect of Daucus carota Root Extract against Ischemia Reperfusion Injury in Rats. Pharmacology, 1, 432-439.
Patil, M.V., Kandhare, A.D. and Bhise, S.D. (2012) Pharmacological Evaluation of Ethanolic Extract of Daucus carota Linn Root Formulated Cream on Wound Healing Using Excision and Incision Wound Model. Asian Pacific Journal of Tropical Biomedicine, 2, S646-S655. http://dx.doi.org/10.1016/S2221-1691(12)60290-1
Muralidharan, P., Balamurugan, G. and Kumar, P. (2008) Inotropic and Cardioprotective Effects of Daucus carota Linn. on Isoproterenol-Induced Myocardial Infarction. Bangladesh Journal of Pharmacology, 3, 74-79.
Sing, K., Dhongade, H., Sing, N. and Kashyap, P. (2010) Hypolipidemic Activity of Ethanolic Extract of Daucus carota Seeds in Normal Rats. International Journal of Biomedical and Advance Research, 1, 73-80. http://dx.doi.org/10.3329/bjp.v3i2.849
Aydin, A.F., Kiraz, Z.K., Abbasoghu, S.D., Gulluoglu, M., Uysal, M. and Toker, N.K. (2010) Effect of Carnosine against Thioacetamide-Induced Liver Cirrhosis in Rat. Peptides, 31, 67-71. http://dx.doi.org/10.1016/j.peptides.2009.11.028
Singh, K., Singh, N., Chandy, A. and Maniganha, A. (2012) In Vivo Antioxidant and Hepatoprotective Activity of Methanolic Extracts of Daucus carota Seeds in Experimental Animals. Asian Pacific Journal of Tropical Biomedicine, 2, 385-388. http://dx.doi.org/10.1016/S2221-1691(12)60061-6
Rezaei-Maghadam, A., Mohajeri, D., Rafiei, B., Dizaji, R., Azhdari, A., Yegomehzad, M., Shahidi, M. and Mazani, M. (2012) Effect of Tumeric and Carrot Seed Extracts on Serum Liver Biomakers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats. Bioimpacts, 2, 151-157.
Vasudevan, M. and Parle, M. (2006) Pharmalogical Evidence for Potential of Daucus carota in the Management of Cognitive Dysfunctions. Biological & Pharmaceutical Bulletin, 29, 1154-1161. http://dx.doi.org/10.1248/bpb.29.1154
Vasudevan, M., Parle, M., Ramasamy, K. and Majeed, A.B.A. (2010) Anti-Dementia Potential of Daucus carota Seed Extracts in Rats. Pharmacologyonline, 1, 552-565.
Nadkarni, K.M. (1976) Indian Material Medica. Vol. I, Popular Prokashan, Bombay.
Gambhir, S.S., Sanyal, A.K., Sen, S.P. and Das, P.K. (1966) Studies on Daucus carota Linn. II. Cholinergic Activity of the Quaternary Base Isolated from Water-Soluble Fraction of Alcoholic Extracts of Seeds. Indian Journal of Medical Research, 54, 1053-1056.
Rossi, P.G., Bao, L., Luciani, A., Panighi, J., Desjobert, J.M., Costa, J., Casanova, J., Bolla, J.M. and Berti, L. (2007) (E)-Methylisoeugenol and Elemicin: Antibacterial Components of Daucus carota L. Essential Oils against Campylobacter jejuni. Journal of Agricultural and Food Chemistry, 55, 7332-7336. http://dx.doi.org/10.1021/jf070674u
Misiaka, I.J., Lipoka, J., Nowakowska, E.M., Wieczoreka, P.P., Mlynarz, P. and Kafarski, P. (2004) Antifungal Activity of Carrot Seed Oil and Its Major Sesquiterpene Compounds. Zeitschrift für Naturforschung, 59, 791-796.
Kumarasamy, Y., Nahar, L., Byres, M., Delazar, A. and Sarker, S.D. (2005) The Assessment of Biological Activities Associated with the Major Constituents of the Methanol Extract of “Wild Carrot” (Daucus carota L.) Seeds. Journal of Herbal Pharmacotherapy, 5, 61-72.
Vasudevan, M., Gunnam, K.K. and Parle, M. (2006) Anticonceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract. Journal of Health Science, 52, 598-606. http://dx.doi.org/10.1248/jhs.52.598
Mornin, R.A., De Witt, D.L. and Nair, M.G. (2003) Inhibition of Cyclooxygenase (COX) Enzymes by Compounds from Daucus carota L. Seeds. Phytotherapy Research, 17, 976-979. http://dx.doi.org/10.1002/ptr.1296
Bhatnagar, U. (1995) Poscoital Contraceptive Effects of an Alcoholic Extract of the Daucus carota Linn Seed in Rats. Clinical Drug Investigation, 9, 30-36. http://dx.doi.org/10.2165/00044011-199509010-00006
Majumder, P.K., Dasgupta, S., Mukhopadhaya, R.K., Majundar, U.K. and Gupta, M. (1997) Anti-Steroidogenic Activity of the Petroleum Ether Extract and Fraction 5 (Fatty Acids) of Carrot (Daucus carota L.) Seeds in Mouse Ovary. Journal of Ethnopharmacology, 57, 209-2012. http://dx.doi.org/10.1016/S0378-8741(97)00056-1
Majundar, U.K., Gupta, M. and Patro, V.J. (1998) Studies on Anti-Fertility of Methanolic Extract of Daucus carota Linn. Seeds. Indian Journal of Natural Products, 14, 33-37.
Nouri, M., Khaki, A., Azar, F.F. and Rashidi, M.R. (2009) The Protective Effects of Carrot Seed Extract on Spermatogenesis and Cauda Epididymal Sperm Reserves in Gentamicin Treated Rats. Yakhteh Medical Journal, 11, 327-333.