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<sup>11</sup>C-Labeled Capsaicin and Its <i>in Vivo</i> Molecular Imaging in Rats by Positron Emission Tomography
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
National Center for Geriatrics and Gerontology, Obu, Japan
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 1 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 2 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 3 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 4 National Center for Geriatrics and Gerontology, Obu, Japan
- 5 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 6 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
- 7 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan
Food and Nutrition Sciences·Volume 06 (2015)·Pages 216–220·Published 2 February 2015·DOI10.4236/fns.2015.62022
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Abstract
Synthesis of 11 C-labeled capsaicin ([ 11 C]-2) was accomplished by O-[ 11 C]methylation with [ 11 C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [ 11 C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [ 11 C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1.
KeywordsPETCapsaicin<sup>11</sup>C-LabelingTRPV1Blood-Brain Barrier
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