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Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

¹ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
² CERELA—Centro de Referencia para Lactobacilos (CONICET), Tucumán, Argentina
³ Sancor CUL, Departamento de Investigación, Innovación y Desarrollo, Sunchales, Argentina
⁴ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
⁵ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
⁶ Sancor CUL, Departamento de Investigación, Innovación y Desarrollo, Sunchales, Argentina
⁷ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
⁸ Sancor CUL, Departamento de Investigación, Innovación y Desarrollo, Sunchales, Argentina
⁹ CERELA—Centro de Referencia para Lactobacilos (CONICET), Tucumán, Argentina
¹⁰ CERELA—Centro de Referencia para Lactobacilos (CONICET), Tucumán, Argentina
¹¹ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
¹² IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina
¹³ IDIP—Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niños de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Pro-vincia de Buenos Aires), La Plata, Argentina

Food and Nutrition Sciences·Volume 06 (2015)·Pages 1583–1590·Published 23 December 2015·DOI10.4236/fns.2015.617163

Abstract

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total ( – 7.86 g/dl) and LDL ( – 7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (10 6 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.

Keywords&lti&gtLactobacillus reuteri &lt/i&gtHypercholesterolemiaCardiovascular RiskProbioticsFunctional Foods

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Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Abstract

References (31)