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Ionic Liquid-Based Ultrasound-Assisted Emulsification Microextraction Coupled with HPLC for Simultaneous Determination of Glucocorticoids and Sex Hormones in Cosmetics
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 1 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 2 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 3 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 4 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 5 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
- 6 Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, China
Green and Sustainable Chemistry·Volume 03 (2013)·Pages 26–31·Published 17 May 2013·DOI10.4236/gsc.2013.32A004
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Abstract
An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the deter mination of nine hormones including three glucocorticoids, one androgen and five progestogens in cosmetics. Several factors that affect the extraction efficiency, such as the kinds and volume of ionic liquid, salt concentration, ultrasonic power and time, and centrifugation time were investigated and optimized. Under the optimum extraction condition, the recoveries of analytes ranged from 85.97 % to 108.84% except prednisolone (62.30%). The intraday and interday precision was below 2.51% and 3.30%, respectively.
KeywordsIonic LiquidUltrasound-Assisted Emulsification MicroextractionHormonesCosmeticsHigh Performance Liquid Chromatography
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