Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid
Department of Chemistry, Gauhati University, Guwahati, India
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Department of Chemistry, Gauhati University, Guwahati, India
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Department of Chemistry, Gauhati University, Guwahati, India
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Indian Institute of Technology, Guwahati, India
1 Department of Chemistry, Gauhati University, Guwahati, India
2 Department of Chemistry, Gauhati University, Guwahati, India
3 Department of Chemistry, Gauhati University, Guwahati, India
Secondary amine based ionic liquid and defective Keggin type heteropoly acid (HPA) are separately used for efficient one - pot four - component synthesis of 1,2,4,5-tetrasubstituted imidazoles assisted by microwave (MW). Eco - friendly solvent free procedure, short reaction time, high yield of products and reusability of catalysts are important features of the synthesis. A comparative study on the efficiency of the two catalysts is reported. This work further demonstrates the alternate use of urea, instead of often used ammonium acetate, as source of nitrogen.
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Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid — Oak Academic Publishing