One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-<i>c</i>][1,3,5]Thiadiazepin-2-Ones Catalyzed by <i>PTSA</i>—A Green Chemistry Approach — Oak Academic Publishing
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One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-<i>c</i>][1,3,5]Thiadiazepin-2-Ones Catalyzed by <i>PTSA</i>—A Green Chemistry Approach
Department of Chemistry, Kakatiya University, Warangal, India
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Department of Chemistry, Kakatiya University, Warangal, India
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Department of Chemistry, Kakatiya University, Warangal, India
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Department of Chemistry, Kakatiya University, Warangal, India
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Department of Chemistry, Kakatiya University, Warangal, India
1 Department of Chemistry, Kakatiya University, Warangal, India
2 Department of Chemistry, Kakatiya University, Warangal, India
3 Department of Chemistry, Kakatiya University, Warangal, India
4 Department of Chemistry, Kakatiya University, Warangal, India
5 Department of Chemistry, Kakatiya University, Warangal, India
The synthesis of novel isoxazolo[2,3- c ][1,3,5]thiadiazepin-2-ones has been achieved in excellent yields by one-pot three-component Domino reaction without the production of toxic waste products by using p -toluene sulfonic acid ( PTSA ) as a Lewis acid catalyst. PTSA plays a crucial role in the success of the reaction, as well as for increasing reaction rate.
KeywordsMulti-Component Green SynthesisIsoxazolo[23-<i>c</i>][135]Thiadiazepin-2-Ones<i>PTSA</i>
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