A Mild and Efficient Method for the Synthesis of Acylals from Aromatic Aldehydes and Their Deprotections Catalyzed by Synthetic Phosphates under Solvent-Free Conditions — Oak Academic Publishing
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A Mild and Efficient Method for the Synthesis of Acylals from Aromatic Aldehydes and Their Deprotections Catalyzed by Synthetic Phosphates under Solvent-Free Conditions
Laboratoire de Chimie Analytique et physicochimie des Matériaux, Université Hassan II, Faculté des Sciences Ben M’Sik, Casablanca, Morocco
An efficient and clean preparation of acylals from aromatic aldehydes in the presence of synthetic phosphates (flourapatite and hydroxyapatite doped with ZnCl2 and ZnBr2) and acetic anhydride was achieved easily in high yields (86% - 97%) at room temperature under solvent-free conditions. Deprotection of the resulting acylals has also been attained by using the same catalysts under microwave irradiation. This method consistently has advantage of excellent yields (82% - 96%) and a short reaction time (3 - 4 min).
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