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Perfect Solvent- and Catalyst-Free Syntheses of Imine Derivatives Using the Pressure Reduction Technique

¹ Faculty of Education, Kyoto University of Education, Kyoto, Japan
² Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
³ Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
⁴ Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
⁵ Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
⁶ Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
⁷ Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan
⁸ Environment Systems Engineering Course, National Institute of Technology, Akita College, Akita, Japan
⁹ Department of Applied Chemistry, National Institute of Technology, Akita College, Akita, Japan
¹⁰ Department of Applied Chemistry, National Institute of Technology, Akita College, Akita, Japan
¹¹ Science et Génie des Matériaux, IUT Blois, Blois, France
¹² Department of Chemical and Biological Engineering, National Institute of Technology, Akita College, Akita, Japan

Green and Sustainable Chemistry·Volume 09 (2019)·Pages 105–118·Published 12 October 2019·DOI10.4236/gsc.2019.94008

Abstract

In the field of organic syntheses, the development of environmentally friendly methods based on the concept of green chemistry has been always required. In response to this requirement, we reported solvent- and catalyst-free syntheses of imines using the pressure reduction technique as a key technology. We found that this reaction proceeded very rapidly in the initial stage, but its rate decreased with the passage of time. It was also found that the reaction of benzaldehyde with aniline had a specificity that the phase transition occurred. In this method, the desired imines could be obtained in good to excellent yields, but target compounds had to be given by purifications using organic solvents. Therefore, we tried to develop the perfect synthetic method of imine derivatives without organic or inorganic solvents. We selected two methods and took them into this investigation. One was exactly mixing (1:1, substance ratio) aldehydes and amines and the other was employing lower pressure (>0.1 mmHg, previous method: 1.0 mmHg) at the pressure reducing technique. When this improved synthetic method was performed, it was revealed that pure target imines were obtained in excellent yields without any purification.

KeywordsSolvent-FreeCatalyst-FreeNeat ReactionPressure Reduction TechniqueImine

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Perfect Solvent- and Catalyst-Free Syntheses of Imine Derivatives Using the Pressure Reduction Technique

Abstract

References (36)