Objective: To investigate the correlation between recurrent spontaneous abortion patients and brain derived neurotrophic factor BDNF gene polymorphism and the mechanism of BDNF and recurrent spontaneous abortion under stress state in order to provide theoretical basis for nursing psychological intervention of patients with recurrent abortion. Methods: Medical coping Questionnaire (MCMO) and post-traumatic stress Diagnostic Scale (POST-traumatic stress Scale) were adopted Dissorder (PTSD) (PCL-c) scale was used to diagnose the psychological stress of recurrent spontaneous abortion in our hospital, and the BDNF gene polymorphism and the correlation factors of METHYLation in BDNF promoter region were studied in 30 cases (control group) and normal control group. Results: The MCMQ score of the case group and the control group was significantly lower than that of the conventional group (P < 0.05), and the scores of “avoidance and submission” were higher than that of the conventional group, with statistical significance (P < 0.05). The distribution of BDNF gene g-712A genotype was significantly different between the case group and the control group. Conclusion: There are significant differences in PTSD between the case group and the control group, which are related to methylation in the PROMOTER region of BDNF and SNP g-712A of BDNF gene. AG patients in the case group are more susceptible to anxiety and depression, and GG PTSD is more severe in the case group. BDNF promoter methylation and G-712A were independent risk factors for PTSD in the case group.
KeywordsRecurrent Spontaneous AbortionBDNFPsychologicalCare to Do
Southwick, S.M. and Charney, D.S. (2012) The Science of Resilience: Implications for the Prevention and Treatment of Depression. Science, 338, 79-82. https://doi.org/10.1126/science.1222942
Pitman, R.K., Rasmusson, A.M., Koenen, K.C., Shin, L.M., Orr, S.P., Gilbertson, M.W., Milad, M.R. and Liberzon, I. (2012) Biological Studies of Post-Traumatic Stress Disorder. Nature Reviews Neuroscience, 13, 769-787. https://doi.org/10.1038/nrn3339
Holbrook, T.L., Galarneau, M.R., Dye, J.L., Quinn, K. and Dougherty, A.L. (2010) Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder. The New England Journal of Medicine, 362, 110-117. https://doi.org/10.1056/NEJMoa0903326
McNally, R.J. (2006) Cognitive Abnormalities in Post-Traumatic Stress Disorder. Trends in Cognitive Sciences, 10, 271-277. https://doi.org/10.1016/j.tics.2006.04.007
Steenkamp, M.M., Litz, B.T., Hoge, C.W. and Marmar, C.R. (2015) Psychotherapy for Military-Related PTSD: A Review of Randomized Clinical Trials. JAMA, 314, 489-500. https://doi.org/10.1001/jama.2015.8370
Bryant, R.A., Ekasawin, S., Chakrabhand, S., Suwanmitri, S., Duangchun, O. and Chantaluckwong, T. (2011) A Randomized Controlled Effectiveness Trial of Cognitive Behavior Therapy for Post-Traumatic Stress Disorder in Terrorist-Affected People in Thailand. World Psychiatry, 10, 205-209. https://doi.org/10.1002/j.2051-5545.2011.tb00058.x
Nagahara, A.H. and Tuszynski, M.H. (2011) Potential Therapeutic Uses of BDNF in Neurological and Psychiatric Disorders. Nature Reviews Drug Discovery, 10, 209-219. https://doi.org/10.1038/nrd3366
Autry, A.E. and Monteggia, L.M. (2012) Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders. Pharmacological Reviews, 64, 238-258. https://doi.org/10.1124/pr.111.005108
Han, E.J., Kim, Y.K., Hwang, J.A., Kim, S.H., Lee, H.J., Yoon, H.K. and Na, K.S. (2015) Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis. Psychiatry Investigation, 12, 112-117. https://doi.org/10.4306/pi.2015.12.1.112
Huang, Y.W., Ruiz, C.R., Eyler, E.C., Lin, K. and Meffert, M.K. (2012) Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis. Cell, 148, 933-946. https://doi.org/10.1016/j.cell.2012.01.036
Karayannis, T., Au, E., Patel, J.C., Kruglikov, I., Markx, S., Delorme, R., et al. (2014) Cntnap4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission. Nature, 511, 236-240. https://doi.org/10.1038/nature13248
Bruenig, D., Lurie, J., Morris, C.P., Harvey, W., Lawford, B., Young, R.M. and Voisey, J. (2016) A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD. Neural Plasticity, 2016, Article ID: 6979435. https://doi.org/10.1155/2016/6979435
Carrard, A., Salzmann, A., Perroud, N., Gafner, J., Malafosse, A. and Karege, F. (2011) Genetic Association of the Phosphoinositide-3 Kinase in Schizophrenia and Bipolar Disorder and Interaction with a BDNF Gene Polymorphism. Brain and Behavior, 1, 119-124. https://doi.org/10.1002/brb3.23
Chen, Z.Y., Jing, D., Bath, K.G., Ieraci, A., Khan, T., Siao, C.J., et al. (2006) Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior. Science, 314, 140-143. https://doi.org/10.1126/science.1129663
Zhang, L., Benedek, D.M., Fullerton, C.S., Forsten, R.D., Naifeh, J.A., Li, X.X., et al. (2014) PTSD Risk Is Associated with BDNF Val66Met and BDNF Overexpression. Molecular Psychiatry, 19, 8-10. https://doi.org/10.1038/mp.2012.180
Vauthey, J.N., Lauwers, G.Y., Esnaola, N.F., Do, K.A., Belghiti, J., Mirza, N., et al. (2002) Simplified Staging for Hepatocellular Carcinoma. Journal of Clinical Oncology, 20, 1527-1536. https://doi.org/10.1200/JCO.2002.20.6.1527
Kilpatrick, D.G., Resnick, H.S., Milanak, M.E., Miller, M.W., Keyes, K.M. and Friedman, M.J. (2013) National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria. Journal of Traumatic Stress, 26, 537-547. https://doi.org/10.1002/jts.21848
Kilpatrick, D.G. (2013) The DSM-5 Got PTSD Right: Comment on Friedman (2013). Journal of Traumatic Stress, 26, 563-566. https://doi.org/10.1002/jts.21844
Dick, J.P., Guiloff, R.J., Stewart, A., Blackstock, J., Bielawska, C., Paul, E.A. and Marsden, C.D. (1984) Mini-Mental State Examination in Neurological Patients. Journal of Neurology, Neurosurgery and Psychiatry, 47, 496-499. https://doi.org/10.1136/jnnp.47.5.496
Zhang, H., Ozbay, F., Lappalainen, J., Kranzler, H.R., van Dyck, C.H., Charney, D.S., Price, L.H., Southwick, S., Yang, B.Z., Rasmussen, A. and Gelernter, J. (2006) Brain Derived Neurotrophic Factor (BDNF) Gene Variants and Alzheimer’s Disease, Affective Disorders, Posttraumatic Stress Disorder, Schizophrenia, and Substance Dependence. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141, 387-393. https://doi.org/10.1002/ajmg.b.30332
Andero, R. and Ressler, K.J. (2012) Fear Extinction and BDNF: Translating Animal Models of PTSD to the Clinic. Genes Brain and Behavior, 11, 503-512. https://doi.org/10.1111/j.1601-183X.2012.00801.x
Cohen, B.E., Neylan, T.C., Yaffe, K., Samuelson, K.W., Li, Y. and Barnes, D.E. (2013) Posttraumatic Stress Disorder and Cognitive Function: Findings from the Mind Your Heart Study. Journal of Clinical Psychiatry, 74, 1063-1070. https://doi.org/10.4088/JCP.12m08291
Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O. and Chao, M.V. (2006) BDNF-Mediated Neurotransmission Relies upon a Myosin VI Motor Complex. Nature Neuroscience, 9, 1009-1018. https://doi.org/10.1038/nn1730
Park, H. and Poo, M.M. (2013) Neurotrophin Regulation of Neural Circuit Development and Function. Nature Reviews Neuroscience, 14, 7-23. https://doi.org/10.1038/nrn3379
Grassi-Oliveira, R., Stein, L.M., Lopes, R.P., Teixeira, A.L. and Bauer, M.E. (2008) Low Plasma Brain-Derived Neurotrophic Factor and Childhood Physical Neglect Are Associated with Verbal Memory Impairment in Major Depression—A Preliminary Report. Biological Psychiatry, 64, 281-285. https://doi.org/10.1016/j.biopsych.2008.02.023
Mahan, A.L. and Ressler, K.J. (2012) Fear Conditioning, Synaptic Plasticity and the Amygdala: Implications for Posttraumatic Stress Disorder. Trends in Neurosciences, 35, 24-35. https://doi.org/10.1016/j.tins.2011.06.007
Saczynski, J.S., Marcantonio, E.R., Quach, L., Fong, T.G., Gross, A., Inouye, S.K. and Jones, R.N. (2012) Cognitive Trajectories after Postoperative Delirium. The New England Journal of Medicine, 367, 30-39. https://doi.org/10.1056/NEJMoa1112923
Soliman, F., Glatt, C.E., Bath, K.G., Levita, L., Jones, R.M., Pattwell, S.S., et al. (2010) A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human. Science, 327, 863-866. https://doi.org/10.1126/science.1181886
Zhai, J., Yu, Q., Chen, M., Gao, Y., Zhang, Q., Li, J., et al. (2013) Association of the Brain-Derived Neurotrophic Factor Gene G196A rs6265 Polymorphisms and the Cognitive Function and Clinical Symptoms of Schizophrenia. International Journal of Clinical and Experimental Pathology, 6, 1617-1623.
Jiang, X., Xu, K., Hoberman, J., Tian, F., Marko, A.J., Waheed, J.F., Harris, C.R., Marini, A.M., Enoch, M.A. and Lipsky, R.H. (2005) BDNF Variation and Mood Disorders: A Novel Functional Promoter Polymorphism and Val66Met Are Associated with Anxiety but Have Opposing Effects. Neuropsychopharmacology, 30, 1353-1361. https://doi.org/10.1038/sj.npp.1300703
Borroni, B., Bianchi, M., Premi, E., Alberici, A., Archetti, S., Paghera, B., Cerini, C., Papetti, A. and Padovani, A. (2012) The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Is Associated with Reduced Hippocampus Perfusion in Frontotemporal Lobar Degeneration. Journal of Alzheimer’s Disease, 31, 243-251. https://doi.org/10.3233/JAD-2012-120226
Iamjan, S.A., Thanoi, S., Watiktinkorn, P., Nudmamud-Thanoi, S. and Reynolds, G.P. (2015) BDNF (Val66Met) Genetic Polymorphism Is Associated with Vulnerability for Methamphetamine Dependence. Pharmacogenomics, 16, 1541-1545. https://doi.org/10.2217/pgs.15.96
Wang, C.K., Xu, M.S., Ross, C., Lo, R., Procyshyn, R.M., Vila-Rodriguez, F., White, R.F., Honer, W.G. and Barr, A.M. (2015) Development of a Cost-Efficient Novel Method for Rapid, Concurrent Genotyping of Five Common Single Nucleotide Polymorphisms of the Brain Derived Neurotrophic Factor (BDNF) Gene by Tetra-Primer Amplification Refractory Mutation System. International Journal of Methods in Psychiatric Research, 24, 235-244. https://doi.org/10.1002/mpr.1475
Agartz, I., Sedvall, G.C., Terenius, L., Kulle, B., Frigessi, A., Hall, H. and Jonsson, E.G. (2006) BDNF Gene Variants and Brain Morphology in Schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141, 513-523. https://doi.org/10.1002/ajmg.b.30338
Zhang, L., Fang, Y., Zeng, Z., Lian, Y., Wei, J., Zhu, H., Jia, Y., Zhao, X. and Xu, Y. (2011) BDNF Gene Polymorphisms Are Associated with Alzheimer’s Disease-Related Depression and Antidepressant Response. Journal of Alzheimer’s Disease, 26, 523-530. https://doi.org/10.3233/JAD-2011-110113
Borroni, B., Grassi, M., Archetti, S., Costanzi, C., Bianchi, M., Caimi, L., Caltagirone, C., Di Luca, M. and Padovani, A. (2009) BDNF Genetic Variations Increase the Risk of Alzheimer’s Disease-Related Depression. Journal of Alzheimer’s Disease, 18, 867-875. https://doi.org/10.3233/JAD-2009-1191