Antibiotic Resistance Profile of <i>Salmonella</i> Strains Isolated at the National Clinical Biology and Public Health Laboratory in Bangui, Central African Republic — Oak Academic Publishing
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Antibiotic Resistance Profile of <i>Salmonella</i> Strains Isolated at the National Clinical Biology and Public Health Laboratory in Bangui, Central African Republic
National Blood Transfusion Center, Bangui, Central African Republic
,
Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
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National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy, Bangui, Central African Republic
,
National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic
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National Center for the Fight against AIDS, Bangui, Central African Republic
,
Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
,
Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
,
Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
,
Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
1 National Blood Transfusion Center, Bangui, Central African Republic
2 Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
3 National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy, Bangui, Central African Republic
4 National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic
5 National Center for the Fight against AIDS, Bangui, Central African Republic
6 Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
7 Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
8 Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
9 Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic
In Africa, each year , there are estimated to be more than 91 million cases of salmonellosis and 137,000 cases of death. The problem of antibiotic resistance in Salmonella strains is a threat to public health. The objective of this study is to evaluate the antibiotic resistance profile of Salmonella strains isolated in biological products analyzed at the National Laboratory of Clinical Biology and Public Health (NLCBPH) in Bangui. This is , therefore , a cross-sectional study with a descriptive aim, running from January to December 2022. It fo cused on the strains of Salmonella isolated and identified in stools, urines, and blood samples. For each strain of Salmonella isolated, an antibiogram was carried out following the recommendations of the French Society of Microbiology (CASFM, 2022). A total of 93 strains of Salmonella have been recorded. The age group 0 - 9 years was 29% and that of >50 years was 11%. The median age of patients was 30 years with a minimum of 1 and a maximum of 78 years. The female gender was more represented at 52.69% than the male gender at 47.31%, i.e. a sex ratio of 0.89 (M/F). Salmonella strains were much more isolated in stools at 62% followed by urines at 29% and blood at 6% . Salmonella arizonae strains were more represented with 52%. Salmonella strains have a resistance rate to Tetracycline of 62.37% followed by Penicillins of 50%. The rate of multi-antibiotic resistance of the Salmonella strains isolated represented 48.38%. Salmonella spp . strains were multi-resistant at 58.69% followed by Salmonella arizonae strains at 47.91%. There is a signifi cant association between the different families of antibiotics and Salmonella strains (p < 0.05). According to the results obtained, Penicillins, Phenicoles, and Cyclins had a high rate of resistance on Salmonella strains. No strain-producing Broad Spectrum Beta-lactamase has been isolated. Salmo nella strains represent a zoonotic health danger , constitute a public health problem and remain a current subject. This germ is resistant to the antibiotics used. It is , therefore , essential to emphasize monitoring the resistance of these germs in the Central African Republic (CAR) to improve the health of the population.
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