Regional Coherence Alterations in Patients with Poststroke Cognitive Impairment after Acupuncture Therapy: A Resting-State fMRI Study — Oak Academic Publishing
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Regional Coherence Alterations in Patients with Poststroke Cognitive Impairment after Acupuncture Therapy: A Resting-State fMRI Study
Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Department of Radiology, Sichuan Province Orthopedic Hospital, Chengdu, China
1 Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
2 Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
3 Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
4 Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
5 Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
6 Department of Radiology, Sichuan Province Orthopedic Hospital, Chengdu, China
Objective : To explore regional homogeneity (ReHo) alterations after acupuncture treatment in poststroke cognitive impairment (PSCI) patients. Methods : Twenty-one PSCI patients who underwent acupuncture therapy in our hospital and 12 matched healthy controls were enrolled in this study. All study subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI); for PSCI patients, rs-fMRI scans were conducted before and after acupuncture therapy. Data preprocessing was performed using the DPARSF5.4 and SPM12 toolkits on the MATLAB 2022b platform. DPARSF5.4 was used to calculate the ReHo index of the preprocessed resting-state data. A two-sample t-test was used to compare the differences in ReHo between the PSCI patients group pretreatment and the control group (with sex and age as covariates), and a paired t-test was used to compare the differences in ReHo between the pretreatment and posttreatment groups of PSCI patients (without covariates). AAL_116_binary_mask.nii was used as the statistical mask, and the statistical results were corrected using family-wise error correction, with P < 0.001 at the voxel level and P < 0.05 at the cluster level considered to indicate statistical significance. Results: In the right cerebellum area 6, the ReHo of the pretreatment PSCI group was significantly greater than that of the control group; in the left middle frontal gyrus, the ReHo of the posttreatment PSCI group was significantly higher than that of the pretreatment group. Conclusion : PSCI patients exhibited abnormal ReHo in the resting state, and ReHo was significantly altered after acupuncture treatment. The results of this study suggest that ReHo might be a potential biomarker in the diagnosis and treatment of PSCI.
Qu, Y., Zhuo, L., Li, N., Hu, Y., Chen, W., Zhou, Y., et al . (2015) Prevalence of Post-Stroke Cognitive Impairment in China: A Community-Based, Cross-Sectional Study. PLOS ONE , 10, e0122864. https://doi.org/10.1371/journal.pone.0122864
Deramecourt, V. and Pasquier, F. (2014) Neuronal Substrate of Cognitive Impairment in Post-Stroke Dementia. Brain , 137, 2404-2405. https://doi.org/10.1093/brain/awu188
Wang, R., Liu, N., Tao, Y., Gong, X., Zheng, J., Yang, C., et al . (2020) The Application of rs-fMRI in Vascular Cognitive Impairment. Frontiers in Neurology , 11, Article 951. https://doi.org/10.3389/fneur.2020.00951
Yang, C., Gao, X., Liu, N., Sun, H., Gong, Q., Yao, L., et al . (2023) Convergent and Distinct Neural Structural and Functional Patterns of Mild Cognitive Impairment: A Multimodal Meta-Analysis. Cerebral Cortex , 33, 8876-8889. https://doi.org/10.1093/cercor/bhad167
Xu, X., Li, X., Qi, X., Jiang, X., Xing, H., Huang, X., et al . (2023) Effect of Regional Intrinsic Activity Following Two Kinds of Theta Burst Stimulation on Precuneus. Human Brain Mapping , 44, 2254-2265. https://doi.org/10.1002/hbm.26207
Hu, T., Hou, Y., Wei, Q., Yang, J., Luo, C., Chen, Y., et al . (2020) Patterns of Brain Regional Functional Coherence in Cognitive Impaired Als. International Journal of Neuroscience , 130, 751-758. https://doi.org/10.1080/00207454.2019.1705806
Hua, Y., Geng, Y., Liu, S., Xia, S., Liu, Y., Cheng, S., Chen, C., Pang, C., Zhao, Z., Peng, B., Dai, Y., Ji, J. and Wu, D. (2024) Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study. Journal of Pain Research , 17, 3959-3971. https://doi.org/10.2147/JPR.S470750
Cheng, S., Zeng, F., Zhou, J., Dong, X., Yang, W., Yin, T., et al . (2024) Altered Static and Dynamic Functional Brain Network in Knee Osteoarthritis: A Resting-State Functional Magnetic Resonance Imaging Study. NeuroImage , 292, Article ID: 120599. https://doi.org/10.1016/j.neuroimage.2024.120599
Luo, C., Guo, X., Song, W., Chen, Q., Yang, J., Gong, Q., et al . (2015) The Trajectory of Disturbed Resting-State Cerebral Function in Parkinson’s Disease at Different Hoehn and Yahr Stages. Human Brain Mapping , 36, 3104-3116. https://doi.org/10.1002/hbm.22831
Han, J., Yang, Y., Wang, Y., Feng, J., Song, C., Wu, W., et al . (2024) Effectiveness and Safety of Governor Vessel Acupuncture Therapy for Post-Stroke Cognitive Impairment: A Meta-Analysis of Randomized Controlled Trials. Ageing Research Reviews , 99, Article ID: 102355. https://doi.org/10.1016/j.arr.2024.102355
Li, Z.T., Ban, L.Q. and Chen, F. (2023) Acupuncture of Revised Acupoint Combination around the Skull Base for Post-Stroke Mild Cognitive Impairment: A Randomized Controlled Trial. Chinese Acupuncture & Moxibustion , 43, 1104-1108.
Li, Y., Cui, R., Liu, S., Qin, Z., Sun, W., Cheng, Y., et al . (2023) The Efficacy and Safety of Post-Stroke Cognitive Impairment Therapies: An Umbrella Review. Frontiers in Pharmacology , 14, Article 1207075. https://doi.org/10.3389/fphar.2023.1207075
Wang, H., Huang, Y., Li, M., Yang, H., An, J., Leng, X., et al . (2022) Regional Brain Dysfunction in Insomnia after Ischemic Stroke: A Resting-State fMRI Study. Frontiers in Neurology , 13, Article 1025174. https://doi.org/10.3389/fneur.2022.1025174
Liu, Z., Wei, W., Bai, L., Dai, R., You, Y., Chen, S., et al . (2014) Exploring the Patterns of Acupuncture on Mild Cognitive Impairment Patients Using Regional Homogeneity. PLOS ONE , 9, e99335. https://doi.org/10.1371/journal.pone.0099335
Guo, J., Chen, N., Li, R., Wu, Q., Chen, H., Gong, Q., et al . (2014) Regional Homogeneity Abnormalities in Patients with Transient Ischaemic Attack: A Resting-State fMRI Study. Clinical Neurophysiology , 125, 520-525. https://doi.org/10.1016/j.clinph.2013.08.010
Wu, W., Song, C., Yang, Y., Hu, Y. and Lin, H. (2024) Acupuncture for Cognitive Impairment after Stroke: A Systematic Review and Meta-Analysis. Heliyon , 10, e30522. https://doi.org/10.1016/j.heliyon.2024.e30522
Liao, C., Lin, J., Tsai, C., Lane, H., Su, T., Wang, H., et al . (2012) An Investigation of the Use of Traditional Chinese Medicine in Stroke Patients in Taiwan Region. Evidence-Based Complementary and Alternative Medicine , 2012, Article ID: 387164. https://doi.org/10.1155/2012/387164
Zhou, Q., Ji, Y., Lv, Y., Xue, J., Wang, Y. and Huang, Y. (2023) Scientific Evidence of Acupuncture for Post-Stroke Cognitive Impairment: An Overview of Systematic Reviews and Meta-Analyses. Neuropsychiatric Disease and Treatment , 19, 1503-1513. https://doi.org/10.2147/ndt.s407162
Li, L., Yang, L., Luo, B., Deng, L., Zhong, Y., Gan, D., et al . (2022) Acupuncture for Post-Stroke Cognitive Impairment: An Overview of Systematic Reviews. International Journal of General Medicine , 15, 7249-7264. https://doi.org/10.2147/ijgm.s376759
Zhuo, P., Huang, L., Lin, M., Chen, J., Dai, Y., Yang, M., et al . (2023) Efficacy and Safety of Acupuncture Combined with Rehabilitation Training for Poststroke Cognitive Impairment: A Systematic Review and Meta-Analysis. Journal of Stroke and Cerebrovascular Diseases , 32, Article ID: 107231. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107231
Li, N., Wang, H., Liu, H., Zhu, L., Lyu, Z., Qiu, J., et al . (2023) The Effects and Mechanisms of Acupuncture for Post-Stroke Cognitive Impairment: Progress and Prospects. Frontiers in Neuroscience , 17, Article 1211044. https://doi.org/10.3389/fnins.2023.1211044
Liu, Y., Chen, F., Qin, P., Zhao, L., Li, X., Han, J., et al . (2023) Acupuncture Treatment vs. Cognitive Rehabilitation for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Neurology , 14, Article 1032125. https://doi.org/10.3389/fneur.2023.1035125
Yan, C., Wang, X., Zuo, X. and Zang, Y. (2016) DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging. Neuroinformatics , 14, 339-351. https://doi.org/10.1007/s12021-016-9299-4
Wang, R., Liu, N., Xu, H., Zhang, P., Huang, X., Yang, L., et al . (2024) Brain Functional Network Changes in Patients with Poststroke Cognitive Impairment Following Acupuncture Therapy. Health , 16, 856-871. https://doi.org/10.4236/health.2024.169061
Zang, Y., Jiang, T., Lu, Y., He, Y. and Tian, L. (2004) Regional Homogeneity Approach to fMRI Data Analysis. NeuroImage , 22, 394-400. https://doi.org/10.1016/j.neuroimage.2003.12.030
Peng, C., Chen, Y., Cui, Y., Zhao, D., Jiao, Y., Tang, T., et al . (2016) Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction. PLOS ONE , 11, e0159574. https://doi.org/10.1371/journal.pone.0159574
Liu, J., Qin, W., Wang, H., Zhang, J., Xue, R., Zhang, X., et al . (2014) Altered Spontaneous Activity in the Default-Mode Network and Cognitive Decline in Chronic Subcortical Stroke. Journal of the Neurological Sciences , 347, 193-198. https://doi.org/10.1016/j.jns.2014.08.049
Yuan, X., Han, Y., Wei, Y., Xia, M., Sheng, C., Jia, J., et al . (2016) Regional Homogeneity Changes in Amnestic Mild Cognitive Impairment Patients. Neuroscience Letters , 629, 1-8. https://doi.org/10.1016/j.neulet.2016.06.047
Ye, Q., Chen, X., Qin, R., Huang, L., Yang, D., Liu, R., et al . (2019) Enhanced Regional Homogeneity and Functional Connectivity in Subjects with White Matter Hyperintensities and Cognitive Impairment. Frontiers in Neuroscience , 13, Article 695. https://doi.org/10.3389/fnins.2019.00695
Sun, J.H., Tan, L. and Yu, J.T. (2014) Post-Stroke Cognitive Impairment: Epidemiology, Mechanisms and Management. Annals of Translational Medicine , 2, 80.
Li, Q., Fadoul, G., Ikonomovic, M., Yang, T. and Zhang, F. (2022) Sulforaphane Promotes White Matter Plasticity and Improves Long-Term Neurological Outcomes after Ischemic Stroke via the Nrf2 Pathway. Free Radical Biology and Medicine , 193, 292-303. https://doi.org/10.1016/j.freeradbiomed.2022.10.001
Darviri, C., Zavitsanou, C., Delikou, A., Giotaki, A., Artemiadis, A., Terentiou, A., et al . (2016) A Novel Non-Pharmaceutical Treatment for Patients with Mild Cognitive Impairment. Psychology , 7, 678-686. https://doi.org/10.4236/psych.2016.75070
Luo, Z., Li, W., Jiang, J., Sun, J., Zhang, M., Zhang, Y., et al . (2024) Effect of Acupuncture on Cognitive Function in Patients with Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis. Brain and Behavior , 14, e70075. https://doi.org/10.1002/brb3.70075