Investigating the Impact of Medicine and Food Homology Substances on Depression Based on Gut Microbiota
- 1 School of Traditional Chinese Medicine, Guangzhou Huali Science and Technology Vocational College, Guangzhou, China
- 2 School of Traditional Chinese Medicine, Guangzhou Huali Science and Technology Vocational College, Guangzhou, China
- 3 Guangzhou Foreign Language School, Guangzhou, China
Abstract
Depression is a common mental disorder, primarily caused by alterations in the function of monoamine neurotransmitters and receptors, neuroendocrine disruptions, as well as inflammation and immune imbalances. Its global incidence has been increasing year by year. Most current antidepressant drugs are associated with prolonged administration and significant side effects. As microorganisms residing in the human gut, disruptions in the gut microbiota can influence the pathogenesis of depression. Medicine and food homology substances, with both therapeutic and nutritional properties, have shown great potential in treating depression. This paper explores how medicine and food homology substances influence the pathogenesis of depression through the modulation of gut microbiota, aiming to provide new insights for depression treatment.
- World Health Organization (2024) Adolescent Mental Health. https://www.who.int/news-room/fact-sheets/detail/adolescent-mental-health
- Malhi, G.S. and Mann, J.J. (2018) Depression. The Lancet , 392, 2299-2312. https://doi.org/10.1016/s0140-6736(18)31948-2
- Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., et al . (2015) Altered Fecal Microbiota Composition in Patients with Major Depressive Disorder. Brain , Behavior , and Immunity , 48, 186-194. https://doi.org/10.1016/j.bbi.2015.03.016
- Wang, X.D. (2023) The Origin, Concept, and Contemporary Development of the Idea of “Medicine and Food Homology”. Journal of Nanjing University of Traditional Chinese Medicine , 39, 809-813.
- Yan, J. and Gu, F.H. (2024) Research Progress on the Pathogenesis and Therapeutic Drugs of Depression. World Clinical Drugs , 45, 430-434.
- Liu, C.L., Ruan, K.F., Gao, J.W., et al . (2013) Multi-Mechanism Pathogenesis of Depression. Progress in Physiology Science , 44, 253-258.
- Mao, J.X., Ma, Q., Peng, Z.L., et al . (2024) The Role of the Prefrontal Cortex Glutamate System and Gut Microbiota in the Pathogenesis of Depression Based on a Chronic Unpredictable Mild Stress Rat Model. International Journal of Psychiatry , 51, 372-377, 381.
- Yang, M., Kang, H.J. and Dai, X.C. (2015) Pathogenesis and Treatment Progress of Depression. Sichuan Journal of Physiological Sciences , 37, 146-150.
- Su, H. (2023) Pathogenesis of Depression and Research Status and Progress of Commonly Used Antidepressant Drugs. Modern Medicine and Health Research , 7, 16-19.
- Human Microbiome Project Consortium (2012) Structure, Function and Diversity of the Healthy Human Microbiome. Nature , 486, 207-214. https://doi.org/10.1038/nature11234
- Cryan, J.F. and Dinan, T.G. (2012) Mind-Altering Microorganisms: The Impact of the Gut Microbiota on Brain and Behaviour. Nature Reviews Neuroscience , 13, 701-712. https://doi.org/10.1038/nrn3346
- Guo, F.T., Jing, L., Xu, Y.F., et al . (2024) Gut Microbiota Characteristics and Their Correlation with Inflammatory Factors in Patients with Major Depressive Disorder. Chinese Journal of Microecology , 36, 788-795.
- Lin, Z., Zu, X.P., Xie, H.S., et al . (2016) Research Progress on the Gut Microbiota and the Pathogenesis of Human Diseases. Acta Pharmaceutica Sinica , 51, 843-852.