Evaluation of the Main Infectious Markers in Family Blood Donors at the Chad-China Friendship Hospital (HATC) in N’Djamena, Chad
- 1 Department of Biomedical and Pharmaceutical Sciences, Faculty of Human Sciences and Health, University of N’Djamena, N’Djamena, Chad
- 2 Renaissance University Hospital Centre, N’Djamena, Chad
- 3 National Coordination of Actions against Covid-19, N’Djamena, Chad
- 4 Chad-China Friendship Hospital, N’Djamena, Chad
- 5 Laboratory of the N’Djamena Psycho-Medical Support Centre, N’Djamena, Chad
- 6 Laboratory of the N’Djamena Psycho-Medical Support Centre, N’Djamena, Chad
- 7 Faculty of Health Sciences, University of N’Djamena, N’Djamena, Chad
- 8 Cancer Control Programme, N’Djamena, Chad
- 9 Department of Biomedical and Pharmaceutical Sciences, Faculty of Human Sciences and Health, University of N’Djamena, N’Djamena, Chad
- 10 Faculty of Health Sciences, University of N’Djamena, N’Djamena, Chad
- 11 Faculty of Health Sciences, University of N’Djamena, N’Djamena, Chad
- 12 Faculty of Health Sciences, University of N’Djamena, N’Djamena, Chad
- 13 Laboratory of Microbiology and Quality Control of Foodstuffs, School of Biological and Food Techniques, University of Lome, Lome, Togo
- 14 University Hospital for Mothers and Children, N’Djamena, Chad
Abstract
In Chad, the majority of blood donations are family-based, so regular serosurveillance of donors for transmissible infectious agents is essential to ensure transfusion safety. The main infectious agents sought in donors are the human immunodeficiency virus (HIV), hepatitis B and C viruses, and Treponem a pallidum , which causes syphilis. The main objective of the study was to determine the seropositivity rate of the main markers in donors in order to ensure transfusion safety at the Chad-China Friendship Hospital in N’Djamena, Chad. It was carried out during the period from January 2014 to December 2019 and is retrospective, prospective and cross-sectional, using blood bank records and information from consenting donors using a standardized form. The serological tests performed were Determine HIV1/2, SD BILONE 1/2 (HIV), HBsAg rapid test SD Bioline (HBV), Rapid test first response Ab (HCV), RPR, B/25 (T. Pallidum). A total of 18,570 donors were identified, with a sex ratio of 6.84 in favor of men. The average age was 35.5 ± 4.5 years. The overall seropositivity rate for infectious markers was (1467/18,570) (7.9%), with (236/18,750) (1.2%) for HIV, (1019/18,570) (5.4%) for hepatitis B (HBV), (26/18,570) (0.1%) for hepatitis C (HCV) and (186/18,570) (1%) for syphilis. Male sex (16203/18,570) (87.25%) and the 26 - 35 age group (7604/18,570) (40.95%) were significantly more represented. Family blood donation remains one of the means used to save human lives in countries with limited resources. In order to ensure the safety of blood transfusions for patients, it is necessary to systematically test for the main markers recommended by the WHO. At the Chad-China Friendship Hospital, where blood donation is mainly family-based, it is therefore essential to strengthen the system of serosurveillance for infectious markers in donors, and to focus the national transfusion policy on voluntary and regular blood donation.
- Yambasu, E.E., Reid, A., Owiti, P., Manzi, M., Sia Murray, M.J. and Edwin, A.K. (2018) Hidden Dangers-Prevalence of Blood Borne Pathogens, Hepatitis B, C, HIV and Syphilis, among Blood Donors in Sierra Leone in 2016: Opportunities for Improvement: A Retrospective, Cross-Sectional Study. Pan African Medical Journal , 30, Article 44. https://doi.org/10.11604/pamj.2018.30.44.14663
- Organisation Mondiale de la Santé (2017) Sécurité transfusionnelle et approvisionnement en sang. https://www.who.int/fr/news-room/fact-sheets/detail/blood-safety-and-availability
- Okoroiwu, H.U., Okafor, I.M., Asemota, E.A. and Okpokam, D.C. (2018) Seroprevalence of Transfusion-Transmissible Infections (HBV, HCV, Syphilis and HIV) among Prospective Blood Donors in a Tertiary Health Care Facility in Calabar, Nigeria; an Eleven Years Evaluation. BMC Public Health , 18, Article No. 645. https://doi.org/10.1186/s12889-018-5555-x
- Noubiap, J.J.N., Joko, W.Y.A., Nansseu, J.R.N., Tene, U.G. and Siaka, C. (2013) Sero-epidemiology of Human Immunodeficiency Virus, Hepatitis B and C Viruses, and Syphilis Infections among First-Time Blood Donors in Edéa, Cameroon. International Journal of Infectious Diseases , 17, e832-e837. https://doi.org/10.1016/j.ijid.2012.12.007
- Jegoura, F. (2018) Seroprevalence de l’hépatite B, C et VIH chez les donneurs du sang à l’hôpital militaire de rabat Maroc. Master’s Thesis, Université Mohamed vrabat.
- Katile, D., Konate, I., Goita, D., Dicko, M., Konate, M. and Malle, O. (2018) Evaluation de la séroprévalence des hépatites virales B et C chez les donneurs de sang en milieu urbain dans un hôpital régional au Mali: Cas de l’hôpital régional Fousseyni Daou de Kayes. Médecine d ’ Afrique Noire , 65, 381-387.
- Kabamba Nzaji, M. and Kabyla Ilunga, B. (2013) Prévalence des marqueurs infectieux chez les donneurs de sang en milieu rural. Cas de l’hôpital général de référence de Kamina. Santé Publique , 25, 213-217. https://doi.org/10.3917/spub.132.0213
- Motayo, B., Faneye, A., Udo, U., Olusola, B., Ezeani, I. and Ogiogwa, J. (2015) Seroprevalence of Transfusion Transmissible Infections (TTI), in First Time Blood Donors in Abeokuta, Nigeria. African Health Sciences , 15, 19-24. https://doi.org/10.4314/ahs.v15i1.3
- Boushab, B.M., Melaïnine Mohamed Limame, O.C., Zahra, F.F., Mamoudou, S., Roseline Darnycka, B.M. and Saliou, S.M. (2017) Estimation of Seroprevalence of HIV, Hepatitis B and C Virus and Syphilis among Blood Donors in the Hospital of Aïoun, Mauritania. Pan African Medical Journal , 28, Article 118. https://doi.org/10.11604/pamj.2017.28.118.12465