Objectives: To advise policy makers, law and administrative practitioners of the new science of physical injury to the brain of healthcare workers (HCWs) due to uncontrollable but not controllable occupational stress. Leaders have the potential and the means to affect the controllability of occupational stress on HCWs. Many resources and guides to do so are in the public domain. Without leadership interventions, the occupational stress remains uncontrollable. OSHA requires employers to provide a workplace free from recognized hazards likely to cause death or serious physical harm. New medical/neurologic findings now raise moral and legal duties for employers to protect healthcare workers from such hazards as uncontrollable occupational stress. Methods: Literature focused upon recent studies that outline severe neurological and medical impact from uncontrollable stress is supported by functional MRI studies and SPECT Scans. We reviewed existing policies, causes of uncontrollable stress on HCWs that exist in the current healthcare delivery environment and known interventions that healthcare leadership can perform to reduce uncontrollable stress by its volume reduction and especially allowing more HCW decisional latitude and participation to influence its reduction. We propose legal theories to incorporate these new findings, as seen in international practices. This process described was undertaken by an interprofessional collaboration of physicians, attorneys and healthcare economists resulting in conclusions and recommendations. Results: Current HCW work environments are characterized by uncontrollable stress manifested by little ability to escape from or influence mitigation of that stress. Leaders of healthcare work environments are in the prime position to reduce the factors that create uncontrollable stress conditions, thereby enabling HCWs psychological safety for feedback, opportunity to influence their work environment, express ideas for improvement, as well as allowing more options for choice in fulfilling their duties. HCW’s uncontrollable stress conditions in their work environment replicate conditions of brain injury and medical sequelae. Burnout is prevalent, well known to be a significant problem in healthcare and is foreseeable. Findings now approach, and likely meet, criteria for the legal standard of a recognized hazard. There are existing methods of recognition and detectability where the impact of HCWs’ uncontrollable stress meets the severity threshold, and there is feasibility of and existing guidance for abatement. Thus, the regulatory and legal risk attached to these issues is currently underappreciated and only likely to increase. National professional organizations recommend interventions in the public domain to reduce burnout and stress. However, healthcare facilities currently view these actions as voluntary. Healthcare workforce leadership have a duty to protect their HCWs and hence their patient constituents from this uncontrollable occupational stress. We must robustly apply organizational methodologies to reduce this stress and improve HCWs health and wellbeing, which ultimately influences patient outcomes. Conclusions : We recommend a focus on engagement of adequate resources and processes via healthcare leadership, as well as awareness and involvement to improve such work conditions. Moral, legal, ethical, patient safety and financial duties exist to command the reduction of uncontrollable stress on HCWs. We recommend Hospital and other healthcare General Counsel advise their CEO and senior leadership about this duty to protect their HCWs and their patients from the impact of uncontrollable stress.
Big Beautiful Bill. H.R. 119th Congress (2025-2026) https://www.congress.gov/119/crec/2025/06/28/171/112/CREC-2025-06-28-pt1-PgS4003-3.pdf
World Health Organization. Burn-Out an “Occupational Phenomenon”. https://www.who.int/standards/classifications/frequently-asked-questions/burn-out-an-occupational-phenomenon
Madsen, I.E.H., Nyberg, S.T., Magnusson Hanson, L.L., Ferrie, J.E., Ahola, K., Alfredsson, L., et al . (2017) Job Strain as a Risk Factor for Clinical Depression: Systematic Review and Meta-Analysis with Additional Individual Participant Data. Psychological Medicine , 47, 1342-1356. https://doi.org/10.1017/s003329171600355x
Arnsten, A.F.T. and Shanafelt, T. (2021) Physician Distress and Burnout: The Neurobiological Perspective. Mayo Clinic Proceedings , 96, 763-769. https://doi.org/10.1016/j.mayocp.2020.12.027
Privitera, M.R. (2018) Is Burnout a Form of Depression? It’s not That Simple. https://www.medscape.com/viewarticle/896537
Wurm, W., Vogel, K., Holl, A., Ebner, C., Bayer, D., Mörkl, S., et al . (2016) Depression-Burnout Overlap in Physicians. PLOS ONE , 11, e0149913. https://doi.org/10.1371/journal.pone.0149913
UpToDate DSM-5-TR Diagnostic Criteria for a Major Depressive Episode https://www.uptodate.com/contents/image?imageKey=PSYCH%2F89994
Rotenstein, L.S., Brown, R., Sinsky, C. and Linzer, M. (2023) The Association of Work Overload with Burnout and Intent to Leave the Job across the Healthcare Workforce during COVID-19. Journal of General Internal Medicine , 38, 1920-1927. https://doi.org/10.1007/s11606-023-08153-z.
Rotenstein, L.S., Torre, M., Ramos, M.A., Rosales, R.C., Guille, C., Sen, S., et al . (2018) Prevalence of Burnout among Physicians. J ournal of the A merican M edical A ssociation , 320, 1131-1150. https://doi.org/10.1001/jama.2018.12777
De Hert, S. (2020) Burnout in Healthcare Workers: Prevalence, Impact and Preventative Strategies. Local and Regional Anesthesia , 13, 171-183. https://doi.org/10.2147/lra.s240564
Dyrbye, L.N. and Shanafelt, T.D. (2017) Burnout among Health Care Professionals A Call to Explore and Address This Underrecognized Threat to Safe, High-Quality Care National Academy of Medicine. Discussion Paper. https://nam.edu/wp-content/uploads/2017/07/Burnout-Among-Health-Care-Professionals-A-Call-to-Explore-and-Address-This-Underrecognized-Threat.pdf
Rhodes, C.A., Hu, X., Freeman, R.B., Agrawal, R., Cherot, E., Dardarian, T.S., et al . (2025) Who’s Not Talking? Nonresponse Bias in Healthcare Employee Well-Being Surveys. Journal of Healthcare Management , 70, 337-353. https://doi.org/10.1097/jhm-d-24-00166
Lopez, K., Li, H., Paek, H., Williams, B., Nath, B., Melnick, E.R., et al . (2024) Predicting Physician Departure with Machine Learning on EHR Use Patterns: A Longitudinal Cohort from a Large Multi-Specialty Ambulatory Practice. PLOS ONE , 19, e0315090. https://doi.org/10.1371/journal.pone.0315090
Blackburn, B., Chan, T., Cherot, E., Freeman, R.B., Hu, X., Matt, E. and Rhodes, C.A. (2023) Beyond Burnout: From Measuring to Forecasting (NBER Working Paper No. 30895). National Bureau of Economic Research.
Anandarajah, A.P., Quill, T.E. and Privitera, M.R. (2018) Adopting the Quadruple Aim: The University of Rochester Medical Center Experience. Moving from Physician Burnout to Physician Resilience. The American Journal of Medicine , 131, 979-986. https://doi.org/10.1016/j.amjmed.2018.04.034
Burden, M., Astik, G., Teleron, A.L. and Amin, A.N. (2025) Administrative Harm. Medical Clinics of North America , 109, 1129-1144. https://doi.org/10.1016/j.mcna.2025.03.003
de Lisser, R., Dietrich, M.S., Spetz, J., Ramanujam, R., Lauderdale, J. and Stolldorf, D.P. (2024) Psychological Safety Is Associated with Better Work Environment and Lower Levels of Clinician Burnout. Health Affairs Scholar , 2, qxae091. https://doi.org/10.1093/haschl/qxae091
Pasmore, W.A. (1988) Designing Effective Organizations: The Sociotechnical Systems Perspective. Wiley.
Pasmore, W., Winby, S., Mohrman, S.A. and Vanasse, R. (2019) Reflections: Sociotechnical Systems Design and Organization Change. Journal of Change Management , 19, 67-85. https://doi.org/10.1080/14697017.2018.1553761
Privitera, M.R. (2022) Promoting Clinician Well-Being and Patient Safety Using Human Factors Science: Reducing Unnecessary Occupational Stress. Health , 14, 1334-1356. https://doi.org/10.4236/health.2022.1412095
Arnsten, A.F.T. (1998) The Biology of Being Frazzled. Science , 280, 1711-1712. https://doi.org/10.1126/science.280.5370.1711
Savic, I. (2015) Structural Changes of the Brain in Relation to Occupational Stress. Cerebral Cortex , 25, 1554-1564. https://doi.org/10.1093/cercor/bht348
Alkadhi, K. (2013) Brain Physiology and Pathophysiology in Mental Stress. ISRN Physiology , 2013, 1-23. https://doi.org/10.1155/2013/806104
Golkar, A., Johansson, E., Kasahara, M., Osika, W., Perski, A. and Savic, I. (2014) The Influence of Work-Related Chronic Stress on the Regulation of Emotion and on Functional Connectivity in the Brain. PLOS ONE , 9, e104550. https://doi.org/10.1371/journal.pone.0104550
Blix, E., Perski, A., Berglund, H. and Savic, I. (2013) Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes. PLOS ONE , 8, e64065. https://doi.org/10.1371/journal.pone.0064065
Elsaid, N., Saied, A., Kandil, H., Soliman, A., Taher, F., Hadi, M., et al . (2021) Impact of Stress and Hypertension on the Cerebrovasculature. Frontiers in Bioscience - Landmark , 26, Article 5057. https://doi.org/10.52586/5057
Guo, H., Zheng, L., Xu, H., Pang, Q., Ren, Z., Gao, Y., et al . (2022) Neurobiological Links between Stress, Brain Injury, and Disease. Oxidative Medicine and Cellular Longevity , 2022, Article 8111022. https://doi.org/10.1155/2022/8111022
Amen, D.G., Raji, C.A., Willeumier, K., Taylor, D., Tarzwell, R., Newberg, A., et al . (2015) Functional Neuroimaging Distinguishes Posttraumatic Stress Disorder from Traumatic Brain Injury in Focused and Large Community Datasets. PLOS ONE , 10, e0129659. https://doi.org/10.1371/journal.pone.0129659
Keator, D.B., Salgado, F., Madigan, C., Murray, S., Norris, S. and Amen, D. (2024) Adverse Childhood Experiences, Brain Function, and Psychiatric Diagnoses in a Large Adult Clinical Cohort. Frontiers in Psychiatry , 15, Article 1401745. https://doi.org/10.3389/fpsyt.2024.1401745
Amen Clinics (2025) Emotional Concussions: The Silent Brain Injury You Might Have. https://www.amenclinics.com/blog/emotional-concussions-the-silent-brain-injury-you-might-have/#:~:text=Emotional%20concussion%20symptoms%20include%3A,fight%2C%20flight%2C%20or%20freeze)
Girotti, M., Bulin, S.E. and Carreno, F.R. (2024) Effects of Chronic Stress on Cognitive Function—From Neurobiology to Intervention. Neurobiology of Stress , 33, Article 100670. https://doi.org/10.1016/j.ynstr.2024.100670
Hanson, M. (2025) Average Medical School Debt. EducationData.org. https://educationdata.org/average-medical-school-debt
Roberts, R. (2018) How Leadership Dynamics in Health Care Can Contribute to Medical Errors, in Leadership Lessons in Healthcare and Public Health. The Ohio State University Press.
Tawfik, D.S., Adair, K.C., Palassof, S., Sexton, J.B., Levoy, E., Frankel, A., et al . (2023) Leadership Behavior Associations with Domains of Safety Culture, Engagement, and Health Care Worker Well-Being. The Joint Commission Journal on Quality and Patient Safety , 49, 156-165. https://doi.org/10.1016/j.jcjq.2022.12.006
Shanafelt, T.D. and Noseworthy, J.H. (2017) Executive Leadership and Physician Well-Being: Nine Organizational Strategies to Promote Engagement and Reduce Burnou. Mayo Clinic Proceedings , 92, 129-146. https://doi.org/10.1016/j.mayocp.2016.10.004
Berger, R., Czakert, J.P., Leuteritz, J. and Leiva, D. (2019) How and When Do Leaders Influence Employees’ Well-Being? Moderated Mediation Models for Job Demands and Resources. Frontiers in Psychology , 10, Article 2788. https://doi.org/10.3389/fpsyg.2019.02788
AMA Definition of Work Outside of Work (WOW). https://edhub.ama-assn.org/steps-forward/audio-player/18810069
Melnick, E.R., Fong, A., Nath, B., Williams, B., Ratwani, R.M., Goldstein, R., et al . (2021) Analysis of Electronic Health Record Use and Clinical Productivity and Their Association with Physician Turnover. JAMA Network Open , 4, e2128790. https://doi.org/10.1001/jamanetworkopen.2021.28790
Dyrbye, L.N., Sotile, W., Boone, S., West, C.P., Tan, L., Satele, D., et al . (2014) A Survey of U.S. Physicians and Their Partners Regarding the Impact of Work-Home Conflict. Journal of General Internal Medicine , 29, 155-161. https://doi.org/10.1007/s11606-013-2581-3
AMA Study Doctors Work 59 Hours per Week. https://edhub.ama-assn.org/steps-forward/audio-player/18810069
Wong, K., Chan, A.H.S. and Ngan, S.C. (2019) The Effect of Long Working Hours and Overtime on Occupational Health: A Meta-Analysis of Evidence from 1998 to 2018. International Journal of Environmental Research and Public Health , 16, Article 2102. https://doi.org/10.3390/ijerph16122102
Monroe County Medical Society (2023) Survey of Physician Workload. https://mcms.org/page-1075399
Privitera, M.R. and MacNamee, K. (2021) Integrating Patient Safety and Clinician Well-Being. Physician Leadership Journal , 8, Article 157850036. https://www.physicianleaders.org/articles/integrating-patient-safety-and-clinician-wellbeing
Hollnagel, E., Wears, R.L. and Braithwaite, J. (2015) Middelfart, Denmark: From Safety-I to Safety-II: A White Paper. Resilient Health Care Net. https://www.england.nhs.uk/signuptosafety/wp-content/uploads/sites/16/2015/10/safety-1-safety-2-whte-papr.pdf
DeChant, P.F., Acs, A., Rhee, K.B., Boulanger, T.S., Snowdon, J.L., Tutty, M.A., et al . (2019) Effect of Organization-Directed Workplace Interventions on Physician Burnout: A Systematic Review. Mayo Clinic Proceedings : Innovations , Quality & Outcomes , 3, 384-408. https://doi.org/10.1016/j.mayocpiqo.2019.07.006
Sinsky, C.A., Biddison, L.D., Mallick, A., Legreid Dopp, A., Perlo, J., Lynn, L., et al . (2020) Organizational Evidence-Based and Promising Practices for Improving Clinician Well-Being. NAM Persp ectives , 2020, 10.31478/202011a.
Longo, B.A., Schmaltz, S.P., Williams, S.C., Shanafelt, T.D., Sinsky, C.A. and Baker, D.W. (2023) Clinician Well-Being Assessment and Interventions in Joint Commission-Accredited Hospitals and Federally Qualified Health Centers. The Joint Commission Journal on Quality and Patient Safety , 49, 511-520. https://doi.org/10.1016/j.jcjq.2023.04.007
Hamidi, M.S., Bohman, B., Sandborg, C., Smith-Coggins, R., de Vries, P., Albert, M.S., et al . (2018) Estimating Institutional Physician Turnover Attributable to Self-Reported Burnout and Associated Financial Burden: A Case Study. BMC Health Services Research , 18, Article No. 851. https://doi.org/10.1186/s12913-018-3663-z
Global Data Plc (2024) The Complexities of Physician Supply and Demand: Projections From 2021 to 2036. AAMC. https://www.aamc.org/media/75236/download
Shanafelt, T.D., Mungo, M., Schmitgen, J., Storz, K.A., Reeves, D., Hayes, S.N., et al . (2016) Longitudinal Study Evaluating the Association between Physician Burnout and Changes in Professional Work Effort. Mayo Clinic Proceedings , 91, 422-431. https://doi.org/10.1016/j.mayocp.2016.02.001
Bui, T., Zackula, R., Dugan, K. and Ablah, E. (2021) Workplace Stress and Productivity: A Cross-Sectional Study. Kansas Journal of Medicine , 14, 42-45. https://doi.org/10.17161/kjm.vol1413424
Cimiotti, J.P., Aiken, L.H., Sloane, D.M. and Wu, E.S. (2012) Nurse Staffing, Burnout, and Health Care-Associated Infection. American Journal of Infection Control , 40, 486-490. https://doi.org/10.1016/j.ajic.2012.02.029
Owen, D.G. (2009) Figuring Foreseeability. Wake Forest Law Review , 44, 1277-1307. https://www.wakeforestlawreview.com/wp-content/uploads/2014/10/Owen_LawReview_December2009.pdf
Kasperczyk, R. (2014) Corporate Responsibility for Systemic Occupational Stress Prevention. Journal of Business Systems , Governance and Ethic s, 5, 51-70. https://doi.org/10.15209/jbsge.v5i3.188
Shain, M. (2004) The Duty to Prevent Emotional Harm at Work: Arguments from Science and Law, Implications for Policy and Practice. Bulletin of Science , Technology & Society , 24, 305-315. https://doi.org/10.1177/0270467604266957
MacKay , C.J., Cousins, R., Kelly, P.J., Lee, S. and McCaig, R.H. (2004) ‘Management Standards’ and Work-Related Stress in the UK: Policy Background and Science. Work & Stress , 18, 91-112. https://doi.org/10.1080/02678370410001727474
Cousins, R., MacKay, C.J., Clarke, S.D., Kelly, C., Kelly, P.J. and McCaig, R.H. (2004) “Management Standards” Work-Related Stress in the UK: Practical Development. Work & Stress , 18, 113-136. https://doi.org/10.1080/02678370410001734322
OSHA General Duty Clause. https://www.osha.com/blog/general-duty-clause
OSHA Work Relatedness https://www.osha.gov/laws-regs/regulations/standardnumber/1904/1904.5
Cunningham, J. (2022) Mental Health and Workers’ Compensation Snapshot. 2022 National Conference of State Legislatures , Denver, 14 October 2022. https://www.ncsl.org/labor-and-employment/mental-health-and-workers-compensation-snapshot
Larson, L.K. and Robinson, T.A. (2026) Larson’s Workers’ Compensation Law. Rev ed. Matthew Bender. § 100.01.
Larson, L.K. and Robinson, T.A. (2026) Larson’s Workers’ Compensation Law. Rev ed. Matthew Bender. §§ 103.03-103.04.
National Academy of Medicine (2022) National Plan for Healthcare Workforce Wellbeing (2022). https://nam.edu/initiatives/clinician-resilience-and-well-being/national-plan-for-he alth-workforce-well-being/ https://nam.edu/publications/national-plan-for-health-workforce-well-being/
Addressing Healthcare Worker Burnout (2022) The U.S. Surgeon General’s Advisory on Building a Thriving Health Workforce. https://www.hhs.gov/sites/default/files/health-worker-wellbeing-advisory.pdf
Wellness-Centered Leadership Playbook Cultivating a Culture of Wellness Within Your Organization (from American Medical Association). https://edhub.ama-assn.org/steps-forward/module/2813422
Well-Being Playbook: A Guide for Hospital and Health System Leaders (from American Hospital Association). https://www.aha.org/system/files/media/file/2019/05/plf-well-being-playbook.pdf
Vogel, L. (2019) Medical Leaders Propose Appointing Wellness Officers to Address Physician Burnout. Canadian Medical Association Journal , 191, E267. https://doi.org/10.1503/cmaj.109-5719
Shanafelt, T., Goh, J. and Sinsky, C. (2017) The Business Case for Investing in Physician Well-Being. JAMA Internal Medicine , 177, 1826. https://doi.org/10.1001/jamainternmed.2017.4340
Yakusheva, O., Lee, K., Fial, A.V. and Weiss, M.E. (2025) Organizational Return on Investment in Nursing: A Systematic Review. International Journal of Nursing Studies , 170, Article 105146. https://doi.org/10.1016/j.ijnurstu.2025.105146