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Antiurolithiatic activity of aqueous extract of bark of moringa oleifera (lam.) in rats
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Abstract
In the present study, aqueous extract of bark of Moringa oleifera administered orally, was eva- luated for its antiurolithiatic potential in albino rats of Wistar strains. The stones were produced in this study by zinc disc foreign body insertion in the bladder supplemented with 1% ethylene glycol in drinking water. The reduction in weight of the stones was used as criteria for assessing the preventive or curative antiurolithiatic effect of the bark of this plant. Two doses of extract for prophylactic and curative groups were used. In both groups the oral administration of the extract of bark of Moringa oleifera has resulted in significant reduction in the weight of bladder stones compared to the control group.
KeywordsMoringa oleifera barkAntiurolithiatic activityIntroduction
- Basu, B.D. and Kirtikar, K.R. (1980) Indian Medicinal Plants, second edn, Bishen Singh Mahendra Pal Singh, Dehradun, 1, 676-683.
- Nadkarni, A.K. (2002) K.M.Nadkarni’s Indian Materia Medica, Popular prakashana, Bombay, 3rd edition, 1, 811-816.
- Vaidyaratnam, P.S.V. (1994) Indian Medicinal Plants-A Compendium of 500 Species. Orient Longman Ltd., Madras, 4, 59-64.
- Fahey, J.W. (2005) Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. Trees for Life Journal, December, 1(5).
- Udupa, S.L., Udupa, A.L. and Kulkarni, D.R. (1994) Studies on the anti-inflammatory and wound healing properties of Moringa oleifera and Aegle marmelos, Fitoterapia, 65, 119-123.
- Udupa, S.L., Udupa, A.L. and Kulkarni, D.R., (1998) A comparative study on the effect of some indigenous drugs on normal and steroid-depressed healing. Fitoterapia, 69, 507-510.
- Guevara, A.P., Vargas, C. and Uy, M. (1996) Anti-in- flammatory and antitumor activities of seed extracts of malunggay, Moringa oleifera L. (Moringaceae), Philippine Journal of Science, 125, 175-184.
- Ruckmani, K., Kavimani, S., Anandan, R. and Jaykar, B, (1998) Effect of Moringa oleifera Lam. on paracetamol induced hepatotoxicity, Indian Journal of Pharmaceutical Science, 60, 33-35.
- Prakash, A.O., Pathak, S., Shukla, S. and Mathur, R. (1988) Pre and post-implantation changes in the uterus of rats: Response to Moringa oleifera Lam. extract, Ancient Science of Life, 8, 49-54.
- Faizi, S., Siddiqui, B.S., Saleem, R., Siddiqui, S., Aftab, K. and Gilani, A.H. (1995) Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry, 38, 957-963.
- Ravindra, V.K., Navneet, B.G., Alagawadi, K.R. and Rudraprabhu, V.S. (2006) Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats. Journal of Ethnopharmacology, 105(1-2), 306-311.
- Caceres A., Saravia A., Rizzo, S., Zabala, L., De Leon, E. and Nave F. (1992) Pharmacological properties of Moringa oleifera 2: Screening for antispasmodic anti-inflammatory and diuretic activity. Journal of Ethnopharmacology, 36, 233-237.
- Ezeamuzi, I.C., Ambakederemo, A.W., Shode, F.O. and Ekwebelem, S.C. (1996) Antiinflammatory effects of Moringa leifera root extract. Journal of Pharmacognosy, 34, 207-212.