Research ArticleOpen AccessGoogle Scholar indexed
Psychotropic effects of aspirin, acetylsalicylate cobalt and acetylsalicylate zinc at various doses
Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
- 1 Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
- 2 Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
- 3 Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
- 4 Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
- 5 Department of Human and Animal Physiology and Biophysics, Faculty of Biology, National Tavrida Vernadskii University, Simfe-ropol, Ukraine
Copy link · social · email
Abstract
For the first time it is shown that psychotropic action of acetylsalicylates at various doses is manifested as a nonmonotonic dependence having its peaks at therapeutic and ultra-low dose zones. It is discovered that development of effects of aspirin resembles that of acetylsalicylate zinc. Acetylsalicylate cobalt at extremely low doses zone showed the highest antidepressant activity, demonstrating toxicity at high doses. Generally, it is revealed that the use of aspirin and its salts at high doses range causes maximum psychotropic effects development, usually accompanied by side-effects. Therefore, aspirin, acetylsalicylate cobalt and zinc at extremely low doses are recommended for further study as psychotropic medications.
KeywordsAcetylsalicylic AcidAcetylsalicylate CobaltAcetylsalicylate ZincPsychotropic ActionBehavioral TestsUltra-Low DosesRats
- Barkagan, Z.S. and Kotovschikova, E.F. (2004) Comparative analysis of main and side effects of various forms of acetylsalicylic acid. Clinical Pharmacology and Therapy, 13, 1-4.
- Ketterer, M.W., Brymer, J., Rhoads, K., Kraft, P. and Lovallo, W.R. (1996) Is aspirin, as used for antithrombosis, an emotion-modulating, agent? Journal of Psycho- somatic Re-search, 40, 53-58. doi:10.1016/0022-3999(95)00524-2
- Alekseyeva, L.I. (2009) Questions of use of non-steroidal anti-inflammatory drugs in rheumatology practice. Consilium Medicum Ukraina, 3, 3-10.
- Tochilkina, L.P. (2007) Phenomenon of extremely low doses, homeopathy and organophosphorus agent. Chemical and Biological Safety, 1, 4-14.
- Ashmarin, I.P., Karazeyeva, Y.P. and Lelekova, T.V. (1999) On the question of development of the problem of effectiveness of extremely low doses of biologically active compounds. Russian Journal of Chemistry, 37, 21- 28.
- Markel, A.L. (1981) To evaluation of general characteristics of rat behavior in the open field test. Journal of Higher Nervous Activity, 31, 301-307.
- Porsolt, R.D., Le Pinchon, M. and Jalfre, M. (1977) Depression: A new animal model sensitive to antidepressant treatments. Nature, 266, 730-732. doi:10.1038/266730a0
- Doutremepuich, C., Aguejouf O., Desplat, V. and Eizay- aga, F.X. (2010) Aspirin therapy: An attempt to explain the events of prothrombotic complications after treatment discontinuation. Thrombosis and Haemostasis, 103, 171- 180. doi:10.1160/TH09-07-0506
- Yakovchyuk, T.V., Katyushyna, O.V., Husainov, D.R., Korenyuk, I.I., Kolotilova, O.I., Gamma, T.V. and Cheretayev, I.V. (2010) Influence of acetylsalicylic acid, cobalt and zinc aspirinates on rat behavior. Series: Biology, Chemistry, 23, 200-208.
- Sazanov, L.A. and Zaitsev, S.V. (1992) Effect of superlow doses (10-18-10-16 М) of biologically active substances: General trends, salient features, and possible mechanisms. Biochemistry, 57, 1443-1460.
- Zhang, J.J., Ding, E.L. and Song, Y.Q. (2006) Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events. Clinician’s Corner, 296, 1619-1632.
- Brenneis, C., Maier, T.J., Schmidt, R., et al. (2006) Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. FASEB Journal, 20, 1352-1360. doi:10.1096/fj.05-5346com
- Chan, F.K. (2002) Celecoxib versus diclofenac and ome-prazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. New England Journal of Medicine, 347, 2104-2110. doi:10.1056/NEJMoa021907