Myocardial infarction in antiphospholipid antibody syndrome
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Abstract
A 52-year-old man was admitted to hospital with chest pain after physical activity. Emergency coronary angiography showed multiple throm-boembolic occlusions in the anterior descen-ding coronary artery and in the right coronary artery. Further testing revealed anticardiolipin and ?2-glicoprotein antibodies (the patient had been diagnosed for ulcerative colitis and poly-myalgia rheumatica). Heparin and nitrate were administered intravenously in addition to oral aspirin and metoprolol. Soon after, the patient referred a withdrawal of chest oppression, and his general clinical condition rapidly stabilised. A follow-up examination was performed 9 months later the discharge: he had resumed most of his activities and sieric concentration of lupus anticoagulant antibodies and anticardiolipin an- tibodies, IgM isotype, were decreased.
- Miyakis, S., Lockshin, M.D., et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis Haemostasis, 4(2), 295-306.
- Levine, J.S., Branch, D.W. and Rauch, J. (2002) The antiphospholipid syndrome. New England Journal of Medicine, 346(10), 752-763.
- Wahl, D.G., Bounameaux, H., de Moerloose, P., et al. (2000) Prophylactic antithrombotic therapy for patients with systemic lupus erythematosus with or without antiphospholipid antibodies: Do the benefits outweight the risks? A decision analysis. Archives of Internal Medicine, 160(13), 2042-2048.
- Ogimoto, A., Sekiya, M., Funada, J., et al. (2000) Anti- phospholipid syndrome with acute myocardial infarction and portal vein occlusion. Journal of Japanese Circulation, 64(6), 468-470.
- Ikeda, Y., Yagi, S., Yamaguchi, H., et al. (2006) Intra- vascular ultrasound findings of diffuse coronary athero- sclerotic change in systemic lupus erythematosus with secondary antiphospholipid syndrome. Circulation Journal, 70(8), 1082-1085.
- Ruffatti, A., Montecucco, C., Volante, D., et al. (2000) Antiphospholipid antibody syndrome and polymyalgia rheumatica/giant cell arteritis. Rheumatology, 39(5), 565- 567.
- Harris, E.N., Khamastha, M.A. and Hughes, G.R.D. (1993) Antiphospho-lipid antibody syndrome. In: McCarty, D.J. and Koopman, W.J., Eds., Arthritis and Allied Conditions, Lea and Febinger, Philadelphia, 1201-1212.