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The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes
Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
Department of Cardiology, Valmontone Hospital, Valmontone, Italy
Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Cardiology, Pomeranian Medical University, Szczecin, Poland
Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
- 1 Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
- 2 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
- 3 Department of Cardiology, Valmontone Hospital, Valmontone, Italy
- 4 Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
- 5 Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
- 6 Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
- 7 Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
- 8 Department of Cardiology, Pomeranian Medical University, Szczecin, Poland
- 9 Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
- 10 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
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Abstract
An association between ADA 1 and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and 398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200 healthy newborns were studied. Written informed consent was obtained from all subjects or from their mothers to participate to the study that was approved by the I.R.B. ADA 1 polymorphism was determined by DNA analysis. Three way contingency table analysis was performed by a log linear model. The association between CAD and ADA 1 is present in non diabetic male subjects only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004 in the Polish population. The data suggest a significant role of immunological mechanisms in the pathogenesis of CAD without diabetes. Gender differences in immune diseases could explain the lack of association in females.
KeywordsADACADGenderDiabetes
- Safranow, K., Rzeuski, R., Binczak-Kuleta, A., Czyzycka, E., Skowronek, J., Jakubowska, K., et al. (2007) ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease. Cardiology, 108, 275-281. doi:10.1159/000099096
- Banci, M., Saccucci, P., D’Annibale, F., Dofcaci, A., Trionfera, G., Magrini, A., et al. (2009) Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology, 112, 74-75. doi:10.1159/000139954
- Spencer, N., Hopkinson, D. and Harris, H. (1968) Adenosin deaminase polymorphism in man. Annals of Human Ge- netics, 32, 9-14. doi:10.1111/j.1469-1809.1968.tb00044.x
- Honing, J., Martiniuk, F., D’Eustachio, P., Zamfirescu, C., Desnick, R., Hirschhorn, K., et al. (1981) Confirmation of the regional localization of genes for human acid-glucosidase and adenosine deaminase by somatic cell hy- bridisation. Annals of Human Genetics, 48, 49-56. doi:10.1111/j.1469-1809.1984.tb00833.x
- Yasuda, N., Inoue, T., Horizoe, T., Nagata, K., Minami, H., Kawata, T., et al. (2003) Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeoenesis in rat hepatocytes. European Journal of Pharmacology, 459, 159-166. doi:10.1016/S0014-2999(02)02832-7
- Barankiewicz, J., Danks, A.M., Abushanab, E., Makings, L., Wiemann, T., Wallis, R.A., et al. (1997) Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors. Journal of Pharmacology and Experimental Therapeutics, 283, 1230-1238.
- Ciruela, F., Saura, C., Canela, E.I., Mallol, J., Lluis, C. and Franco, R. (1996) Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors. FEBS Letters, 380, 219-223. doi:10.1016/0014-5793(96)00023-3
- Heusch, G. and Schulz, R. (1997) Endogenous protective mechanisms in myo-cardial ischemia: Hibernation and ischaemic preconditioning. American Journal of Cardiology, 80, 26A-33A. doi:10.1016/S0002-9149(97)00455-4
- Jackson, E.K., Koehler, M., Mi, Z., Dubey, R.K., Tofovic, S.P., Carcillo, J.A., et al. (1996) Possible role of adeno- sine deaminase in vaso-occlusive diseases. Journal of Hypertension, 14, 9-29. doi:10.1097/00004872-199601000-00003
- McCallion, K., Harkin, D.W. and Gardiner, K.R. (2004) Role of adenosine in immunomodulation: Review of the literature. Critical Care Medicine, 32, 273-277. doi:10.1097/01.CCM.0000098026.12020.45
- Sokal, R.R. and Rohlf, F.J. (1981) Biometry. Freeman, New York.