Clopidogrel in ischemic heart disease: A critical appraisal
- 1 Adult Cardiology Department, Prince Sultan Cardiac Center (PSCC), Riyadh, Saudi Arabia
- 2 Adult Cardiology Department, Prince Sultan Cardiac Center (PSCC), Riyadh, Saudi Arabia.
Abstract
A spirin and clopidogrel are the commonest dual antiplatelet agents being used in the secondary p revention of cardiovascular disease. In high risk patients with coronary heart disease, the use of aspirin was associated with a significant risk reduction of myocardial infarction, stroke and vascular death. The use of clopidogrel alone was slightly superior to aspirin, and associated with reduced risk of vascular death, ischemic stroke and myocardial infarction. Dual antiplatelet therapy has been well studied in patients with acute coronary syndrome and those undergoing per cutaneous coronary intervention (PCI). In p atients with stable coronary heart disease or multiple risk factors the combination of clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing MI, stroke or death from cardiovascular causes .
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