One-time injection of calcitonin induces glucose intolerance in children with the first degree obesity — Oak Academic Publishing
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One-time injection of calcitonin induces glucose intolerance in children with the first degree obesity
Federal State-Financed Establishment of Science State Scientific Center of Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
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Institute of Physiology Named by I.P.Pavlov of the Russian Academy of Sciences, Sanct-Petersburg, Russia
1 Federal State-Financed Establishment of Science State Scientific Center of Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
2 Institute of Physiology Named by I.P.Pavlov of the Russian Academy of Sciences, Sanct-Petersburg, Russia
The effect of calcitonin on the blood glucose level in glucose-tolerance test of children with the first degree obesity was studied. Initial blood glucose level was normal and glucose-tolerance test per os didn’t expose glucose tolerance impairment in children under control. Calcitonin didn’t change initial glucose concentration but evoked impairment of glucose tolerance. The girls with the first degree obesity were more sensitive to hyperglycemic effect of calcitonin than the boys. Sex specificities must be taken into consideration in calcitonin treatment. Besides one ought mean that the increasing secretion of calcitonin occurs in stress-reactions. In these conditions endogenous calcitonin can make the same effect on the regulation of carbohydrate metabolism as exogenous injections of hormone.
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