Oral low-dose estradiol plus norethisterone acetate with or without simvastatin in dyslipidemic and symptomatic menopausal women: A randomized clinical trial — Oak Academic Publishing
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Oral low-dose estradiol plus norethisterone acetate with or without simvastatin in dyslipidemic and symptomatic menopausal women: A randomized clinical trial
Postgraduate Student in Gynecology, Obstetricsand Mastology, Universidade Estadual de S?o Paulo (Unesp), Botucatu, S?o Paulo, Brazil
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Assistant Physician, Gynecological Endocrinologyand Menopause Division, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
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Assistant Professor, Department of Gynecologyand Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
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Assistant Professor, Department of Gynecologyand Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
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Head of the Gynecological Endocrinology and Menopause Division, Department of Gynecology and Obstetrics, Faculdade de Medi- cina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
1 Postgraduate Student in Gynecology, Obstetricsand Mastology, Universidade Estadual de S?o Paulo (Unesp), Botucatu, S?o Paulo, Brazil
2 Assistant Physician, Gynecological Endocrinologyand Menopause Division, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
3 Assistant Professor, Department of Gynecologyand Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
4 Assistant Professor, Department of Gynecologyand Obstetrics, Faculdade de Medicina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
5 Head of the Gynecological Endocrinology and Menopause Division, Department of Gynecology and Obstetrics, Faculdade de Medi- cina do ABC (FMABC), S?o Bernardo do Campo, S?o Paulo, Brazil
Context and Objective: Cardiovascular diseases are the leading causes of death in postmenopausal women and dyslipidemia has important contributing factor. The objective of the study was to evaluate low-dose estrogen plus progestogen therapy (EPT) + simvastatin for vasomotor symp toms and lipid and lipoprotein profiles. Design and Setting: Clinical trial was conducted in a private clinical research center. Methods: Two hundred forty symptommatic postmenopausal women with dyslipidemia were randomized to one of three treatment groups: A) 1 mg estradiol/ 0.5 mg norethisterone acetate (E2/NETA) + 20 mg simvastatin; B) E2/NETA + placebo; or C) 20 mg simvastatin + placebo. Lipid and lipoprotein profiles and menopausal symptoms were evaluated after 16 weeks. Results: Total cholesterol, LDL cholesterol, non-HDL cholesterol decreased (P < 0.05) in all three groups, Apo-B/Apo-A1 and ApoB (P < 0.01) in groups A and C and TG and ApoA1 only in group A comparing baseline versus final. Comparing the groups, group B showed differences in relation to others in total cholesterol, non-HDL cholesterol, LDL cholesterol, Apo B and ApoB/Apoa1 (P < 0.01). Relief of menopausal symptoms was better compared in A and B. Conclusions: Thus in postmenopausal women with dyslipidemia, the association of E2/ NETA low-dose with simvastatin relieved cli macteric symptoms similar to that observed with isolated E2/NETA and improved lipid and lipoprotein profile similar to the isolated use of simvas tatin. The use of E2/NETA alone decreased meno pausal symptoms, but did not improve dyslipidemia.
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