The potential biological mechanisms of obesity effects on depression: A systematic review of the literature and knowledge mining — Oak Academic Publishing
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The potential biological mechanisms of obesity effects on depression: A systematic review of the literature and knowledge mining
School of Social Development and Public Policy, Beijing Normal University, Beijing, China;School of Psychology, Beijing Normal University, Beijing, China
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Department of Paediatrics, Yuquan Hospital, Tsinghua University, Beijing, China
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School of Social Development and Public Policy, Beijing Normal University, Beijing, China;
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School of Social Development and Public Policy, Beijing Normal University, Beijing, China;
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Department of Mental Health, Yuquan Hospital, Tsinghua University, Beijing, China
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School of Psychology, Beijing Normal University, Beijing, China
1 School of Social Development and Public Policy, Beijing Normal University, Beijing, China;School of Psychology, Beijing Normal University, Beijing, China
2 Department of Paediatrics, Yuquan Hospital, Tsinghua University, Beijing, China
3 School of Social Development and Public Policy, Beijing Normal University, Beijing, China;
4 School of Social Development and Public Policy, Beijing Normal University, Beijing, China;
5 Department of Mental Health, Yuquan Hospital, Tsinghua University, Beijing, China
6 School of Psychology, Beijing Normal University, Beijing, China
Depression and obesity (BMI ≥ 30) have been recognized as major public health issues worldwide. Although they have traditionally been compartmentalized as separate physical and emotional health conditions, evidence has suggested interactions and common pathways between them, implying that they probably shared common underlying biological mechanisms. By a systematic review of the literature and knowledge mining, we explore a potential biological mechanism of obesity effects on depression. Bioactivators in the body of obesity including adiponectin, leptin and its receptors, ghrelin, endocannabinoids and orexin receptors may contribute to depression by the hypothalamic pituitary adrenal axis, psycho-neuro-immunological system, neurovegetative system and brain areas control of mood and emotion such as hippocampus, cortex and amygdala.
KeywordsObesityDepressionBiological MechanismsLiterature and Knowledge Mining
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