The angiotension converting enzyme (ACE) gene I/D polymorphism in different ethnic groups of geriatric age living in the Far North — Oak Academic Publishing
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The angiotension converting enzyme (ACE) gene I/D polymorphism in different ethnic groups of geriatric age living in the Far North
Yakutsk Science Centre of Complex Medical Problems, Siberian Branch of the Russian Academy of Medical Science, Yakutsk, Russia
,
Мedical Institute, North-Eastern Federal University Named after M. K. Ammosov, Yakutsk, Russia
,
Yakutsk Science Centre of Complex Medical Problems, Siberian Branch of the Russian Academy of Medical Science, Yakutsk, Russia
1 Yakutsk Science Centre of Complex Medical Problems, Siberian Branch of the Russian Academy of Medical Science, Yakutsk, Russia
2 Мedical Institute, North-Eastern Federal University Named after M. K. Ammosov, Yakutsk, Russia
3 Yakutsk Science Centre of Complex Medical Problems, Siberian Branch of the Russian Academy of Medical Science, Yakutsk, Russia
The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of age there is a decrease in the frequency of the genotype ACE*I / *I and a tendency of increase in the frequency of the genotype ACE*D / *D . A comparative analysis of genotypes АСЕ *D / *D and АСЕ *D / *I has showed sex differences in the frequency of homozygous genotype detection. Left ventricular hypertrophy can be observed significantly more often among carriers of genotype ACE * I / *I established by Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.
KeywordsCHDGeriatric AgeRisk FactorsACE GeneNon-Indigenous and Yakut Patients
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