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Sertraline Induced Acute Hepatitis: A Case Report
Department of Medicine, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaymaniyah, Iraq
Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq
Department of Medicine, Faculty of Medical specialties, Kurdistan Board for Medical specialties, Erbil, Iraq
- 1 Department of Medicine, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaymaniyah, Iraq
- 2 Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq
- 3 Department of Medicine, Faculty of Medical specialties, Kurdistan Board for Medical specialties, Erbil, Iraq
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Abstract
Depression is a common disorder amongst the general population and frequently encountered by most physicians. Selective Serotonin Re-Uptake Inhibitors (SSRI’s) have become the most commonly prescribed antidepressants due to their superiority compared with other antidepressants in the treatment of acute major depression. Although exceedingly rare, hepatotoxicity resulting from sertraline use has been previously reported. In these case reports, the liver injury pattern was predominately hepatocellular. Unlike previous cases, we report the case of a patient presenting with markedly elevated cholestatic enzymes and painless jaundice while taking sertraline for treatment of depression.
KeywordsSertralineObsessive-Compulsive DisorderAcute Hepatitis
- DeVane, C.L., Liston, H.L. and Markowitz, J.S. (2002) Clinical Pharmacokinetics of Sertraline. Clinical Pharmacokinetics, 41, 1247-1266. http://dx.doi.org/10.2165/00003088-200241150-00002
- Product Information (2012) Zoloft (Sertraline Hydrochloride) US Physician Prescribing Information. Pfizer, New York.
- Croft, H., Settle Jr., E., Houser, T., et al. (1999) A Placebo-Controlled Comparison of the Antidepressant Efficacy and Effects on Sexual Functioning of Sustained-Release Bupropion and Sertraline. Clinical Therapeutics, 21, 643-658. http://dx.doi.org/10.1016/S0149-2918(00)88317-4
- Christopher, F.D., Boyapati, R., Simpson, I., et al. (2013) Acute Liver Injury Secondary to Sertraline. BMJ Case Reports, 2, 21-29. http://dx.doi.org/10.1136/bcr-2013-201022
- Persky, S. and Reinus, J.F. (2003) Sertraline Hepatotoxicity: A Case Report and Review of the Literature on Selective Serotonin Reuptake Inhibitor Hepatotoxicity. Digestive Diseases and Sciences, 48, 939-944. http://dx.doi.org/10.1023/A:1023007831047
- Brahmania, M.S.Z., Rosenfeld, G. and Yoshida, E. (2011) Sertraline Induced Hepatotoxicity: A Case Report and Review of Literature. Internet J Gastroenterol, 57, 987-989.
- Collados, V., Hallal, H. and Andrade, R.J. (2010) Sertraline Hepatotoxicity: Report of a Case and Review of the Literature. Digestive Diseases and Sciences, 55, 1806-1807. http://dx.doi.org/10.1007/s10620-010-1192-7
- Biour, M., Poupon, R., Grange, J.D., Chazouilleres, S.L., et al. (2002) He′patotoxicite′ des me′dicaments: Mise a` jour du fichier bibliographique des atteintes he′patiques et des me′dicaments responsables. Gastroenterol. Clin. Biol., 16, 64-88.
- Li, Y., Couch, L., Higuchi, M., et al. (2012) Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent. Toxicological Sciences, 127, 582-591. http://dx.doi.org/10.1093/toxsci/kfs100
- Devuyst, O., Lefebvre, C., Geubel, A., et al. (1993) Acute Cholestatic Hepatitis with Rash and Hypereosinophilia Associated with Ranitidine Treatment. Acta Clinica Belgica, 48, 109-114.
- Collados Arroyo, V., Plaza Aniorte, J., Hallal, H. and Pérez-Cuadrado, E. (2008) Hepatotoxicidad asociada a sertralina. Farmacia Hospitalaria, 32, 60-61. http://dx.doi.org/10.1016/S1130-6343(08)72814-9
- Fartoux-Heymann, L., Hézode, C., Zafrani, E.S., Dhumeaux, D. and Mallat, A. (2001) Acute Fatal Hepatitis Related to Sertraline. Journal of Hepatology, 35, 683-684. http://dx.doi.org/10.1016/S0168-8278(01)00159-3