Materials and Methods: lymphocytes of 10 pa-tients having early rheumatoid arthritis (RA) (the duration of the illness was 3 - 6 months) with a marked exudational process in joints were ex-amined. The content of lymphocytes expressing the CD3, CD4, CD8, CD16, CD56, CD20, CD72, CD38, CD23, CD25, CD71, HLA-DR, CD95, CD30, CD54, mIgM, mIgG antigens was determined. Results: the “Taban-Arshan” extract corrects the changes of the immune system characterized by the evident activation of the B-cell part of the immune system and normalizes immune parameters of the lymphocytes taken from the patients with autoimmune diseases (early rheumatoid arthritis). The immunocorrective effect of the “Taban-Arshan” extract is related to its ability to suppress the lymphocyte increased activation by normalizing expression of the main activation antigens (CD23, CD25, CD71, HLA-DR, CD54).
KeywordsEarly Rheumatoid ArthritisSubpopulation of LymphocytesTibetan MedicineImmunoregulators
Proskuryakov, S.Y. and Gabai, VL. (2010) Mechanisms of tumor cell necrosis. Current Medicinal Chemistry, 16, 2010, 56-68. doi:10.2174/138161210789941793
Flad, H.D. and Brandt, E. (2010) Platelet-derived chemokines: Pathophysiology and therapeutic aspects. Cellular and Molecular Life Sciences, 7, 2010.
Stromberg, S.P. and Carlson, J.M. (2010) The suppression of immune system disorders by passive attrition. PLoS One, 5, 2010, 9648-9649.
Bach, J.F. (2005) Infections and autoimmune diseases. Journal of Autoimmunity, 25, 2005, 74-80. doi:10.1016/j.jaut.2005.09.024
Liu, Y., Dao, Z., Yang, C., Liu, Y. and Long, C. (2009) Medicinal plants used by Tibetans in Shangri-la, Yunnan, China. Journal of Ethnobiology and Ethnomedicine, 5, 2009, 15-16. doi:10.1186/1746-4269-5-15
Zhang, Z., Luo, P., Li, J., Yi, T., Wang, J., An, J. and Zhang, H. (2008) Comparison of the antiinflammatory activities of three medicinal plants known as “meiduoluomi” in Tibetan folk medicine. Yakugaku Zasshi, 128, 2008, 805-810. doi:10.1248/yakushi.128.805
Darshan, S. and Doreswamy, R. (2004) Patented antiinflammatory plant drug development from traditional medicine. Phytotherapy Research, 18, 2004, 343-357. doi:10.1002/ptr.1475
Talhouk, R.S., Karam, C., Fostok, S., El-Jouni, W. and Barbour, E.K. (2007) Anti-inflammatory bioactivities in plant extracts. Journal of Medicinal Food, 10, 2007, 1-10.
Olivo, E.L. (2009) Protection throughout the life span: The psychoneuroimmunologic impact of Indo-Tibetan meditative and yogic practices. The New York Academy of Sciences, 1172, 2009, 163-171. doi:10.1111/j.1749-6632.2009.04415.x
Badmaev, P.A. (1991) Fungamentals of the Tibetan medical science Chzhud-shi. Science.
Ayusheeva, L.V. (2006) Tibetan medicine in Buryatiya. Problems of Social Hygiene, Health Protection and History of Medicine, 5, 58-60.
Serebrennikova, Yu.A., Sakanyan, E.I., Каbyshev, K.E. and Sakanyan, K.М. (2005) Balneotherapy in today medical practice. Herald of VTU Series: Chemistry, Biology and Pharmacy, 1, 225-235.
Semenova, L.S., Sakanyan, E.I., Blinova, K.F., Bal’zhirov, B.G., Sambueva, Z.G., Merdygeeva, А.K., Moldaver, B.L. and Bartanov, А.I. (1997) “Taban-Arshan” phytopreparation for a balneal practice. Tibetan medicine. Traditions, perspectives, integration: Theses of reports on scientific-practice conference. Ulan-Ude, 80-82.
Korsun, V.F., Nikolarv, S.М., Dargaeva, Т.D., Rossiyskaya, G.I., Korsun, E.V. and Aleksandrov, Yu.N. (2004) Polyphytochol in therapy of liver diseases. Practical Phytotherapy, 3, 43-47.
Dashinamzhilov, Zh.B. (2008) Therapeutic effectiveness of “Polyphytochol” phytocollection in a complex therapy of alcohol damages of liver of patients with chronic alcoholism. Narcology Issues: Science and Practice, 4, 90-96.
Butov, М., Korsun, V., Korsun, Е. and Aleksandrov, Yu. (2005) Polyphytochol at functional disfunction of the biliary tract. Doctor, 1, 60-61.
Ubeeva, I.P., Ayusheva, S.Ts., Baldanov, B.V. and Zherbanova, L.V.(2007) An effect of “Baikalsky-7” phytocollection on chronic toxic hepatitis. Bulletin of the Eastern Siberian Scientific Center, 5, 54-56.
Potanin, A.Y., Timofeev, V.T., Shostak, N.A. and Anichkov, D.A. (2006) Phenotype of peripheral blood lymphocytes and serum immunoglobulin concentration in patients with early rheumatoid arthritis. Bulletin of Experimental Biology and Medicine, 141, 2006, 84-86.
Pincus, T. and Sokka, T. (2008) Mortality in rheumatic diseases: Introduction. Clinical and Experimental Rheumatology, 26, 35-61.
Miranda-Carús, M.E., Balsa, A., Benito-Miguel, M., Pérez de Ayala, C. and Martín-Mola, E. (2004) IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: Effect of methotrexate. The Journal of Immunology, 173, 2004, 1463-1476.
Ancu?a, C., Ancu?a, E., Iordache, C., Ceau?u, M. and Chirieac, R. (2009) Immunohistochemical study of skeletal muscle in rheumatoid myositis. Romanian Journal of Morphology and Embryology, 50, 2009, 223-227.
Shimojima, Y., Matsuda, M., Ishii, W., Gono, T. and Ikeda, S. (2008) Analysis of peripheral blood lymphocytes using flow cytometry in polymyalgia rheumatica, RS3PE and early rheumatoid arthritis. Clinical and Experimental Rheumatology, 26, 2008, 1079-1082.
Ria, F., Penitente, R,, De Santis, M., Nicolò, C., Di Sante, G., Orsini, M., Arzani, D., Fattorossi, A., Battaglia, A. and Ferraccioli, G.F. (2008) Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis. Arthritis Research & Therapy, 10, 2008, R135. doi:10.1186/ar2553
Haas, C., Aicher, W.K., Dinkel, A., Peter, H.H. and Eibel, H. (1997) Characterization of SV40T antigen immortalized human synovial fibroblasts: Maintained expression patterns of EGR-1, HLA-DR and some surface receptors. Rheumatology International, 16, 1997, 241-247. doi:10.1007/BF01375656
Galligan, C.L., Siebert, J.C., Siminovitch, K.A., Keystone, E.C., Bykerk, V., Perez, O.D. and Fish, E.N. (2009) Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: Implications for diagnosis and monitoring drug therapy. PLoS One, 20, 2009, 6703.
Klimiuk, P.A., Fiedorczyk, M., Sierakowski, S. and Chwiecko, J. (2007) Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis. Scandinavian Journal of Rheumatology, 36, 2007, 345-350.
Montecucco, F., Burger, F., Pelli, G., Poku, N.K., Berlier, C., Steffens, S. and Mach, F. (2009) Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. Rheumatology, 48, 233-242. doi:10.1093/rheumatology/ken466
Lee, S.I., Lee, S.Y., Yoon, K.H., Choi, K.S., Jang, K.Y., Yoo, W.H., Kim, S.H., Choi, T.H. and Park, J.G. (1999) Molecular MR imaging for visualizing ICAM-1 expression in the inflamed synovium of collagen-induced arthritic mice. Korean Journal of Radiology, 10, 1999, 472-480. doi:10.3348/kjr.2009.10.5.472
Gerli, R., Bistoni, O., Lunardi, C., Giacomelli, R., Tomassini, C., Biagini, P. and Pitzalis, C. (1999) Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy. Rheumatology, 38, 1999, 1282-1284. doi:10.1093/rheumatology/38.12.1282
Savolainen, E., Matinlauri, I., Kautiainen, H., Luosuj?rvi, R. and Kaipiainen-Sepp?nen, O. (2008) Serum soluble CD30 in early arthritis: A sign of inflammation but not a predictor of outcome. Clinical and Experimental Rheumatology, 26, 2008, 922-925.