Research ArticleOpen AccessGoogle Scholar indexed
Intestinal Microbiota, Obesity and Insulin Resistance—What Are the Relationships?
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
Diabetology Department, Malteser Krankenhaus St. Franziskus Hospital, Flensburg, Germany
Harvard T. H. Chan School of Public Health, Boston, MA, USA
- 1 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 2 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 3 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 4 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 5 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 6 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 7 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 8 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 9 Endocrinology Division, IPEMED Medical School, Sao Paulo, Brazil
- 10 Diabetology Department, Malteser Krankenhaus St. Franziskus Hospital, Flensburg, Germany
- 11 Harvard T. H. Chan School of Public Health, Boston, MA, USA
Copy link · social · email
Abstract
Obesity is a public health problem and its prevalence increases every year, resulting from a complex interaction between genetic, metabolic and environmental factors, as well as cultural influences. The Intestinal Microbiota is composed of trillions of microorganisms by forming a symbiotic relationship with the host and helping the absorption of various nutrients, increasing the extraction of components of the diet, the lipogenesis and intestinal permeability. Studies show that there is difference between the composition of the intestinal microbiota of an obese person and a healthy one. The purpose of this article is to review the literature on the relationship between the Intestinal Microbiota, Obesity and Insulin Resistance and also illustrate some studies on the subject.
KeywordsObesityIntestinal MicrobiotaInsulin Resistance
- Pistelli, G.C. and Costa, C.E.M. (2010) Bactérias Intestinais e Obesidade. Bacterias Intestinais e Obesidade. Revista Saúde e Pesquisa, 3, 115-119.
- Martinez, R.C.R. (2015) Scientific Evidence for Health Effects Attributed to the Consumption of Probiotics and Prebiotics: An Update for Current Perspectives and Future Challenges. British Journal of Nutrition, 114, 1993-2015. https://doi.org/10.1017/S0007114515003864
- Coll, A.P., Farooqi, I.S. and O’rahilly, S. (2007) The Hormonal Control of Food Intake. Cell, 129, 251-262. https://doi.org/10.1016/j.cell.2007.04.001
- WHO (2018) Obesity and Overweight, Fact Sheet. http://www.who.int/mediacentre/factsheets/fs311/en/
- Pliquett, R.U., et al. (2006) The Effects of Insulin on the Central Nervous System—Focus on Appetite Regulation. Hormone and Metabolic Research, 38, 442-446. https://doi.org/10.1055/s-2006-947840
- Saad, M.J., Santos, A. and Prada, P.O. (2016) Vinculando Microbiota Gut e Inflamacao à Obesidade e à Resistencia à Insulina. Fisiologia (Bethesda), 31, 283-293.
- Spezia, G., Silva, L.T., Santos, S.P., Liberati, R. and Navarro, F. (2009) Microbiota intestinal e sua relacao com a obesidade. Revista Brasileira de Obesidade, Nutricao e Emagrecimento, 3, 260-267.
- Penteado, J.O., Salgado, R.G.F. and Barlen, E. (2017) A eficácia do tratamento da Obesidade através de transplante da microbiota fecal de indivíduos magros. Vitalle, 29, 46-53.
- Boulangé, C.L., Neves, A.L., Chilloux, J., Nicholson, J.K. and Dumas, M.E. (2016) Impact of the Gut Microbiota on Inflammation, Obesity, and Metabolic Disease. Genome Medicine, 8, 42. https://doi.org/10.1186/s13073-016-0303-2
- Collado, M.C., Salminen, S. and Isolauri, E. (2008) Early Differences in Fecal Microbiota Composition in Children May Predict Overweight. American Journal of Clinical Nutrition, 87, 534-538. https://doi.org/10.1093/ajcn/87.3.534
- Trabulsi, L.R. and Sampaio, M.C. (2008) Microbiota Normal do Corpo Humano. In: Microbiologia, 5a edicao, Atheneu, Rio de Janeiro, 103-110.
- Kim, K.A., Gu, W., Lee, I.A., Joh, E.H. and Kim, D.H. (2012) High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway. PLoS One, 7, e47713. https://doi.org/10.1371/journal.pone.0047713
- Backhed, F., Ding, H., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A., et al. (2004) The Gut Microbiota as an Environmental Factor That Regulates Fat Storage. Proceedings of the National Academy of Sciences of the United States of America, 101, 15718-15723. https://doi.org/10.1073/pnas.0407076101