Study the Effect of Spironolactone in Airway Resistance with Impulse Oscillometry in Patients with Congestive Heart Failure

Abstract

Background: CHF (Congestive Heart Failure) is one of the most important causes of mortality and morbidity in the world. Diuretics such as spironolactone can decrease pulmonary congestion and reduce the amount of fibrosis in CHF patients. The goal was to assess whether spironolactone can decrease air way resistance and can we follow up the effect of diuretic therapy in patients of heart failure quantitatively by means of impulse oscillometry. Methods: It was clinical trial which performed in Ahvaz teaching hospital. 24 patients with congestive heart failure (CHF) which was classified as functional class II-IV and had EF < 40%, were assessed by impulse oscillometry before and after 1 month of taking spironolactone in addition to routine drug therapy for their symptoms. All data were analyzed by SPSS soft ware versed 16. Result: The age of patient was 61 ± 10 and the age of control was 57 ± 7 years old. The data of oscillometry before and after spironolactone were X5 ( &minus; 0.14 ± 0.05 vs &minus; 0.14 ± 0.05, P : 0.93), R5 (0.39 ± 0.21 vs 0.39 ± 0.15, P : 0.35), X20 ( &minus; 0.04 ± 0.06 vs &minus; 0.06 ± 0.06, P : 0.37), R20 (0.04 ± 0.03 vs 0.06 ± 0.06, P : 0.37), Zrs (0.39 ± 0.21 vs 0.39 ± 0.15, P : 0.35). Conclusion: There was a trend toward reduction of peripheral airway resistances in CHF patients than controls with use of 1 month of spironolactone. Although there was not significant change in the number of X5, R5, X20, R20 occurred the trend toward reduction of number triggers the point that oscillometry can be used for quantitative follow up of CHF patients.