We compared the levels of muscle strength between subjects with and without proteinuria. We used data of 721 men and 1,063 women, aged 20-79 years, in this cross-sectional investigation study. Parameters at muscle strength i.e. grip strength, leg strength and leg strength per body weight were evaluated. Proteinuria was measured by urine strip devices. Thirty five men (4.9%) and 27 women (2.5%) were diagnosed as having the proteinuria (+: 30 mg/dl) ≦). Leg strength and leg strength per body weight in men with proteinuria was significantly lower than that in men without proteinuria after adjusting for age. Grip strength in men with proteinuria was also lower than that in men without, but not at a significant level. However such link was not noted in women after adjusting for age. Among Japanese, proteinuria might be a modifiable factor of muscle strength in Japanese men.
KeywordsProteinruiaGrip StrengthLeg StrengthLeg Strength per Body Weight
Foley, R.N., Parfrey, P.S. and Sarnak, M.J. (1998) Clini- cal epidemiology of cardiovascular disease in choronic renal disease. American Journal of Kidney Diseases, 32, S112-S119. doi:10.1053/ajkd.1998.v32.pm9820470
National Kidney Foundation K/DOQI clinical practice guidelines for chronic kidney disease, evaluation, classification, and stratification. (2002) Kidney Disease Outcome Quality Initiative. American Journal of Kidney Diseases, 39, S1-S266.
Imai, E., Horio, M., Iseki, K., Yamagata, K., Watanabe, T., Hara, S., Ura, N., Kiyohara, Y., Hirakata, H., Moriyama, T., Ando, Y., Nitta, K., Inaguma, D., Narita, I., Iso, H., Wakai, K., Yasuda, Y., Tsukamoto, Y., Ito, S., Makino, H., Hishida, A. and Matsuo, S. (2007) Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clinical and Experimental Nephrology, 11, 156-163. doi:10.1007/s10157-007-0463-x
Matsuo, S., Imai, E., Horio, M., Yasuda, Y., Tomita, K., Nitta, K., Yamagata, K., Tomino, Y., Yokoyama, H. and Hishida, A. (2009) Revised equations for estimated GFR from serum creatinine in Japan. American Journal of Kidney Diseases, 53, 982-992. doi:10.1053/j.ajkd.2008.12.034
Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2010) Relationship between Estimated Glomerular Filatration Rate (eGFR) and Metabolic Syndrome in the Japanese Population. Acta Medica Okayama, 64, 203- 208.
Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2011) Comparison of ventilatory threshold between subjects with and without proteinuria in Japanese. Health, 6, 394-399. doi:10.4236/health.2011.36066
Metter, E.J., Talbot, L.A., Schrager, M. and Conwit, R. (2002) Skeletal muscle strength as a predictor of all- cause mortality in healthy men. The Journals of Geron- tology, Series A, 57, B359-B365. doi:10.1093/gerona/57.10.B359
Ministry of Health, Labor and Welfare (2010) http://www.nih.go.jp/eiken/programs/pdf/guidelines2006.pdf.
Rhodes, E.C., Martin, A.D., Taunton, J.E., Donnelly, M., Warren, J. and Elliot, J. (2000) Effect of one year of resistance training on the relation between musclar strength and bone density in elderly women. British Journal of Sports Medicine, 34, 18-22. doi:10.1136/bjsm.34.1.18
Geliebter, A., Mahaer, M.M., Gerace, L., Gutin, B., Heymsfield, S.B. and Hashim, S.A. (1997) Effects of strength or aerobic training on body composition, resting metabolic rate, and peak oxygen consumption in obese dieting subjects. American Journal of Clinical Nutrition, 66, 557-563.
(2005) Definition and the diagnostic standard for metabolic syndrome—Committee to Evaluate Diagnostic Standards for Metabolic Syndrome. Nippon Naika Gakkai Zasshi, 94, 794-809 (in Japanese). doi:10.2169/naika.94.794
Miyatake, N., Wada, J., Nishikawa, H., Saito, T., Takenami, S., Miyachi, M., Makino, H. and Numata, T. (2007) Comparison of muscle strength between Japanese men with and without metabolic syndrome. Acta Medica Okayama, 66, 99-102.
Kigawa, A., Yamamoto, T., Koyama, Y., Kageyama, S. and Arima, K. (1987) Evaluation of knee extensor strength for prevention of sports injury. Japanese Orthopaedic Society of Sports Medicine, 6, 141-145 (in Japanese).
Wallace, J.F., Pugia, M.J., Lott, J.A., Luke, K.E., Shihabi, Z.K., Sheehan, M. and Bucksa, J.M. (2001) Multisite evaluation of a new dipstick for albumin, protein and creatinine. Journal of Clinical Laboratory Analysis, 15, 231-235. doi:10.1002/jcla.1032
Anavekar, N.S., McMurray, J.J., Velazquez, E.J., Solomon, S.D., Kober, L., Rouleau, J.L., White, H.D., Nordlander, R., Maggioni, A., Dickstein, K., Zelenkofske, S., Leimberger, J.D., Califf, R.M. and Pfeffer, M.A. (2004) Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. The New England Journal of Medicine, 351, 1285-1295. doi:10.1056/NEJMoa041365
Irie, F., Iso, H., Sairenchi, T., Fukasawa, N., Yamagishi, K., Ikehara, S., Kanasahiki, M., Saito, Y., Ota, H. and Nose, T. (2006) The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney International, 69, 1264-1271. doi:10.1038/sj.ki.5000284
Fouque, D., Kalantar-Zadeh, K., Kopple, J., Cano, N., Chauveau, P., Cuppari, L., Franch, H., Guarnieri, G., Ikizler, T.A., Kaysen, G., Lindholm, B., Massy, Z., Mitch, W., Pineda, E., Stenvinkel, P., Trevino-Becerra, A. and Wanner, C. (2008) A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney International, 73, 391- 398. doi:10.1038/sj.ki.5002585
Carrero, J.J., Chmielewski, M., Axelsson, J., Sanedal, S., Heimburger, O., Baraby, P., Suliman, M.E., Lindholm, B., Stenvinkel, P. and Qureshi, A.R. (2008) Muscle atrophy, inflammation and clinical outcome in incident and prevalent dialysis patients. Clinical Nutrition, 27, 557- 564. doi:10.1016/j.clnu.2008.04.007
Leal, V.O., Mafra, D., Fouque, D. and Anjos, L.A. (2011) Use of handgrip strength in the assessment of the muscle function of chronic kidney disease patients on dialysis: a systematic review. Nephrology Dialysis Transplantation, 26, 1354-1360. doi:10.1093/ndt/gfq487
Takhreem, M. (2008) The effectiveness of intradialytic exercise prescription on quality of life in patients with chronic kidney disease. The Medscape Journal of Medicine, 10, 226.
Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2010) Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese. Internal Medicine, 49, 1315-1320. doi:10.2169/internalmedicine.49.3085