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Reducing Side Effects of Chloroquine with <i>Medicinal Synthetic Aluminum-Magnesium Silicate</i>® [Msams: Al<sub>4</sub>(SiO<sub>4</sub>)<sub>3</sub> + 3Mg<sub>2</sub>SiO<sub>4</sub> →2Al<sub>2</sub>Mg<sub>3</sub>(SiO<sub>4</sub>)<sub>3</sub>] before Assessing Its Anti-Covid-19 Efficacy
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
Directorate of Information Computer Technology, Michael Okpara University of Agriculture, Umudike, Nigeria
- 1 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 2 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 3 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 4 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 5 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 6 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 7 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 8 College of Veterinary Medicine, M’ichael Okpara University of Agriculture, Umudike, Nigeria
- 9 Directorate of Information Computer Technology, Michael Okpara University of Agriculture, Umudike, Nigeria
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Abstract
To reduce Chloroquine’s (CQ) side effects, so that increasing its duration for anti- Covid -19 trials could be safe, the drug was potentiated by stabilizing it with Medicinal synthetic Aluminum-magnesium silicate (MSAMS). CQ-treatment for five Plasmodium berghie -infected mice-groups were: 7 mg/kg (normal dose); 7 mg/kg (CQ-MSAMS); 7 mg/kg (CQ-MSAMS + B-vitamins), 5.25 mg/kg (CQ-MSAMS + B-vitamins) and the control. Means of parasitaemia, 42.00 ± 15.74 of the normal-dose group, 37.22 ± 11.88 of the 7 mg/kg (CQ-MSAMS) group and 33.57 ± 12.62 of the 7 mg/kg (CQ-MSAMS + B-vitamins) group showed no significant (P ≥ 0.05) reduction from 52.50 ± 11.99 of the control, but the 5.25 mg/kg (CQ-MSAMS + B-vitamins) dose, cleared (P ≤ 0.01) the parasiteamia (00.00 ± 00.00), showing that MSAMS-potentiated Chloroquine, has best efficacy at 75% of the recommended dose. Fever and anemia were absent at that 5.25 mg/kg, suggesting that lower doses of CQ have reduced side effects.
KeywordsAntiviral Treatment with ChloroquineLower DosesReduction of Side EffectsMSAMS
- Singh, B., Kim-Sung, L. and Matusop, A. (2004) A Large Focus of Naturally Acquired Plasmodium Knowlesi Infection in Human Beings. The Lancet, 363, 1017-1024. https://doi.org/10.1016/S0140-6736(04)15836-4
- Mueller, I., Zimmerman, P.A. and Reeder, J.C. (2007) Plasmodium Malria and Plasmodium ovale—“Bashful Malaria Parasite”. Trends in Parasitology, 23, 278-283. https://doi.org/10.1016/j.pt.2007.04.009
- Vincke, I.H. and Lips, M. (1948) Plasmodium berghei. Annales de la Societe Belge de Medecine Tropical, 28, 97-104.
- Escalante, A. and Ayala, F. (1994) Phylogeny of the Malarial Genus, Plasmodium, Derived from RNA Gene Sequences. Proceedings of the National Academy of Sciences USA, 91, 11373-11377. https://doi.org/10.1073/pnas.91.24.11373
- Collins, W.E. and Aikawa, M. (1977) Plasmodia of Non-Human Primates. In: Kreier, J.P., Ed., Parasitic Protozoa, Academic Press, New York, 467-492.
- Chen, Q., Schlichtherle, M. and Wahlgren, M. (2000) Molecular Aspects of Severe Malaria. Clinical Microbiology Review, 13, 439-450. https://doi.org/10.1128/CMR.13.3.439
- Snow, R.W., Querra, C.A., Noor, A.M., Myint, H.Y. and Hay, S.I. (2005) The Global Distribution of Clinical Episodes of Plasmodium falciparum Malaria. Nature, 434, 214-217. https://doi.org/10.1038/nature03342
- Wards, B.P. and Fidock, D. (2004) Understanding How the Malaria Parasite Resists Chloroquine. Molecular Cell, 15, 867-877. https://doi.org/10.1016/j.molcel.2004.09.012
- Wellems, T.E. (2002) Plasmodium, Chloroquine Resistance and the Search for a Replacement Antimalarial Drug. Science, 298, 124-126. https://doi.org/10.1126/science.1078167
- Technical Literature-Veegum Inc. (1992) The Versatile Ingredient for Pharmaceutical Formulations. http://www.rtvanderbilt.com
- Elendu-Eleke, N.P. (2014) Effect of Aluminum-Magnesium Silicate on Antiplasmodial Activity of Chloroquine Phosphate. M.Sc., University of Nigeria, Nsukka.
- Ezeibe, M.C.O., Nwaogu, I.C., Nwaigwe, A.N., Okoroafor, O.N., Eze, J.I. and Ngene, A.A. (2010) Aluminum-Magnesium Silicate Inhibits Canine parvovirus and Cures Infected Dogs. Health, 2, 1215-1217. https://doi.org/10.4236/health.2010.210179
- Brent, W., Gigi, H.R., Khalid, H.I. and John, C.R. (2001) What Do We Really Know about Antibiotic Pharmacodynamics? Pharmacotherapy, 21, 3028-3088.
- Ezeibe, M.C.O., Ofafor, U.C., Okoroafor, O.N., Eze, J.I., Ngene, A.A., Animoke, P.C. and Mbuko, I.J. (2011) Effect of Aluminium-Magnesium Silicate on Anticoccidial Activity of Sulphadimidin. Tropical Veterinary, 29, 41-44.