Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery
- 1 Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- 2 Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- 3 Guangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- 4 Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- 5 Department of Medicine Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- 6 Department of Medicine Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Abstract
Objective: The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. Methods: 154 T4 colorectal cancer patients who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University were included in the study between August, 1994 and December, 2005. Some clinical variables were selected and statistically correlated with prognosis. Results: The overall survival time was 91.7 months at the end of December of 2010 or death. The complete cytoreduction had significant survival benefit than the palliative surgery group. The age, location, histological grade, complete cytoreduction and liver metastasis were associated with overall survival time (OS) according to the univariate analysis (P < 0.05). In addition, Cox multivariate analysis showed that the complete cytoreduction (CCR) and liver metastasis were independent factor influencing survival. Conclusion: Compared with palliative surgery, the incomplete cytoreduction fails to improve patient prognosis. Patients performed completed cytoreduction have a relative good prognosis.
- Brenner, H., Kloor, M. and Pox, C.P. (2014) Colorectal Cancer. Lancet, 383, 1490-1502. https://doi.org/10.1016/S0140-6736(13)61649-9
- Gebhardt, C., Meyer, W., Ruckriegel, S. and Meier, U. (1999) Multivisceral Resection of Advanced Colorectal Carcinoma. Langenbeck’s Archives of Surgery, 384, 194-199. https://doi.org/10.1007/s004230050191
- Jayne, D.G., Fook, S., Loi, C. and Seow-Choen, F. (2002) Peritoneal Carcinomatosis from Colorectal Cancer. British Journal of Surgery, 89, 1545-1550. https://doi.org/10.1046/j.1365-2168.2002.02274.x
- Santvoort, H.C.V., Braam, H.J., Spekreijse, K.R., Koning, N.R., de Bruin, P.C., de Vries Reilingh, T.S., et al. (2014) Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors. Annals of Surgical Oncology, 21, 1686-1691. https://doi.org/10.1245/s10434-013-3461-0
- Koppe, M.J., Boerman, O.C., Oyen, W.J. and Bleichrodt, R.P. (2006) Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies. Annals of Surgery, 243, 212-222. https://doi.org/10.1097/01.sla.0000197702.46394.16
- Takeshita, K., Liu, Y., Ishibashi, H. and Yonemura, Y. (2017) Laparoscopic Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Gastric Cancer: Its Beneficial Effects on Reduction and Exact Evaluation of the Peritoneal Cancer Index. American Surgeon, 83, 1315-1320. https://doi.org/10.1177/000313481708301138
- Lukas, R.V., Mata-Machado, N.A., Nicholas, M.K., Salgia, R., Antic, T. and Villaflor, V.M. (2016) Leptomeningeal Carcinomatosis in Esophageal Cancer: A Case Series and Systematic Review of the Literature. Diseases of the Esophagus, 28, 772-781. https://doi.org/10.1111/dote.12276
- Delhorme, J.B., Dupontkazma, L., Addeo, P., Lefebvre, F., Triki, E., Romain, B., et al. (2016) Peritoneal Carcinomatosis with Synchronous Liver Metastases from Colorectal Cancer: Who Will Benefit from Complete Cytoreductive Surgery? International Journal of Surgery, 25, 98-105. https://doi.org/10.1016/j.ijsu.2015.11.025
- Gu, F.M., Chi, F.L., Dai, C.F., Chen, B. and Li, H.W. (2013) Surgical Outcomes of 43 Cases with Adenoid Cystic Carcinoma of the External Auditory Canal. American Journal of Otolaryngology, 34, 394-398. https://doi.org/10.1016/j.amjoto.2013.01.018
- Kelder, W., Inberg, B., Schaapveld, M., Karrenbeld, A., Grond, J., Wiggers, T. and Plukker, J.T. (2009) Impact of the Number of Histologically Examined Lymph Nodes on Prognosis in Colon Cancer: A Population-Based Study in the Netherlands. Diseases of the Colon & Rectum, 52, 260-267. https://doi.org/10.1007/DCR.0b013e3181979164