Multiple Myeloma in a Patient with Rectal Cancer
- 1 Department of Laboratory Medicine, Zhenjiang First People’s Hospital, Zhenjiang, China
- 2 Department of Laboratory Medicine, Zhenjiang First People’s Hospital, Zhenjiang, China
Abstract
Multiple myeloma is characterized by the accumulation of clonal, malignant plasma cells in the bone marrow. Multiple lytic skeletal lesions in some tumor patients with multiple myeloma are easily considered as bone metastases secondary to tumors, resulting in a missed diagnosis of multiple myeloma. Herein, we report a rare case, in which rectal cancer with multiple myeloma was initially misdiagnosed with bone metastases secondary to rectal cancer, due to the symptoms of multiple lytic sketetal lesions, and ignoring the abnormal plasma cells in the peripheral circulating blood smear. The patient was finally diagnosed with coexistence of rectal cancer and multiple myeloma. The case focuses on the importance of the peripheral circulating blood smear detection.
- Kazandjian, D. (2016) Multiple Myeloma Epidemiology and Survival: A Unique Malignancy. Seminars in Oncology, 43, 676-681. https://doi.org/10.1053/j.seminoncol.2016.11.004
- Ravi, G. and Gonsalves, W.I. (2021) Current Diagnosis, Risk Stratification and Treatment Paradigms in Newly Diagnosed Multiple Myeloma. Cancer Treatment and Research Communications, 29, Article ID: 100444. https://doi.org/10.1016/j.ctarc.2021.100444
- Cullis, J. (2019) Haematology: Multiple Myeloma. Clinical Medicine (London, England), 19, 188-189. https://doi.org/10.7861/clinmedicine.19-2-188a
- Egan, P.A., Elder, P.T., Deighan, W.I., O’Connor, S.J.M. and Alexander, H.D. (2020) Multiple Myeloma with Central Nervous System Relapse. Haematologica, 105, 1780-1790. https://doi.org/10.3324/haematol.2020.248518
- Nassar, S., Taher, A., Spear, R., Wang, F., Madewell, J.E. and Mujtaba, B. (2021) Multiple Myeloma: Role of Imaging in Diagnosis, Staging, and Treatment Response Assessment. Seminars in Ultrasound, CT and MRI, 42, 184-193. https://doi.org/10.1053/j.sult.2020.08.019
- Nau, K.C. and Lewis, W.D. (2008) Multiple Myeloma: Diagnosis and Treatment. American Family Physician, 78, 853-859.
- (2017) Multiple Myeloma. American Family Physician, 95.
- Cowan, A.J., Green, D.J., Kwok, M., Lee, S., Coffey, D.G., Holmberg, L.A., Tuazon, S., Gopal, A.K. and Libby, E.N. (2022) Diagnosis and Management of Multiple Myeloma: A Review. JAMA, 327, 464-477. https://doi.org/10.1001/jama.2022.0003
- Michels, T.C. and Petersen, K.E. (2017) Multiple Myeloma: Diagnosis and Treatment. American Family Physician, 95, 373-383.
- Nandra, T.K., Devi, A. and Jones, J.R. (2022) Multiple Myeloma: What a Non-Haematologist Should Know. Clinical Medicine (London, England), 22, 230-233. https://doi.org/10.7861/clinmed.2022-0144
- Coleman, R.E., Croucher, P.I., Padhani, A.R., Clezardin, P., Chow, E., Fallon, M., Guise, T., Colangeli, S., Capanna, R. and Costa, L. (2020) Bone Metastases. Nature Reviews Disease Primers, 6, 83. https://doi.org/10.1038/s41572-020-00216-3
- Ribourtout, B. and Zandecki, M. (2015) Plasma Cell Morphology in Multiple Myeloma and Related Disorders. Morphologie, 99, 38-62. https://doi.org/10.1016/j.morpho.2015.02.001
- Fornetti, J., Welm, A.L. and Stewart, S.A. (2018) Understanding the Bone in Cancer Metastasis. Journal of Bone and Mineral Research, 33, 2099-2113. https://doi.org/10.1002/jbmr.3618