This study explores the predictive value of plasma a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) levels for major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD). 595 patients admitted to our hospital were selected. Initially, the serum ADAMTS-5 levels of subjects were analyzed. Subsequently, a receiver operating characteristic (ROC) curve was constructed. Furthermore, the serum levels of ADAMTS-5 were assessed in patients, and based on CAD severity, they were categorized into stable angina pectoris (SAP), unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) groups, with the aim of examining the relationship between ADAMTS-5 levels and CAD severity. Differences in clinical outcomes between patients with high and low levels of ADAMTS-5 were analyzed during the follow-up period. The study found that the serum levels of ADAMTS-5 were significantly higher in the group of patients with coronary artery disease (CAD) compared to the group without CAD, indicating its potential as a diagnostic marker for CAD. The ADAMTS-5 levels in the serum of STEMI patients were higher than those with SAP, while NSTEMI patients showed higher levels of ADAMTS-5 than the UA group. There was a positive correlation between serum ADAMTS-5 levels and the syntax score in CAD patients, suggesting a potential association with adverse clinical outcomes in patients with acute myocardial infarction (AMI). This study indicates that ADAMTS-5 shows promise as a biomarker for CAD and highlights the need for further research and validation.
Duggan, J.P., Peters, A.S., Trachiotis, G.D. and Antevil, J.L. (2022) Epidemiology of Coronary Artery Disease. The Surgical Clinics of North America, 102, 499-516. https://doi.org/10.1016/j.suc.2022.01.007
Liu, C., Dhindsa, D., Almuwaqqat, Z., et al. (2022) Association between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-Risk Populations. JAMA Cardiology, 7, 672-680. https://doi.org/10.1001/jamacardio.2022.0912
Rezaee, M., Fallahzadeh, A., Sheikhy, A., et al. (2022) BMI Modifies HDL-C Effects on Coronary Artery Bypass Grafting Outcomes. Lipids in Health and Disease, 21, Article No. 128. https://doi.org/10.1186/s12944-022-01739-2
Sorokin, A.V., Patel, N., Abdelrahman, K.M., et al. (2022) Complex Association of Apolipoprotein E-Containing HDL with Coronary Artery Disease Burden in Cardiovascular Disease. JCI Insight, 7, e159577.
Crea, F., Montone, R.A. and Rinaldi, R. (2022) Pathophysiology of Coronary Microvascular Dysfunction. Circulation Journal: Official Journal of the Japanese Circulation Society, 86, 1319-1328. https://doi.org/10.1253/circj.CJ-21-0848
Wang, Z., Su, J., Gong, F., Xue, L. and Su, Z. (2022) The Impaired Mechanism and Facilitated Therapies of Efferocytosis in Atherosclerosis. Journal of Cardiovascular Pharmacology, 80, 407-416. https://doi.org/10.1097/FJC.0000000000001311
Ma, Z., Mao, C., Chen, X., et al. (2023) Peptide Vaccine against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia. Circulation, 147, 728-742. https://doi.org/10.1161/CIRCULATIONAHA.122.061516
Lawler, P.R., Bhatt, D.L., Godoy, L.C., et al. (2021) Targeting Cardiovascular Inflammation: Next Steps in Clinical Translation. European Heart Journal, 42, 113-131. https://doi.org/10.1093/eurheartj/ehaa099
Didangelos, A., Mayr, U., Monaco, C. and Mayr, M. (2012) Novel Role of ADA-MTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis. Journal of Biological Chemistry, 287, 19341-19345. https://doi.org/10.1074/jbc.C112.350785
Thou, E.M.H., Choo, Q.C. and Chew, C.H. (2020) IL-17A Induction of ADAMTS-5 in Differentiated THP-1 Cells Is Modulated by the ERK Signaling Pathway. European Cytokine Network, 31, 59-67. https://doi.org/10.1684/ecn.2020.0446
Ozkaramanli Gur, D., Guzel, S., Akyuz, A., Alpsoy, S. and Guler, N. (2018) The Role of Novel Cytokines in Inflammation: Defining Peripheral Artery Disease among Patients with Coronary Artery Disease. Vascular Medicine, 23, 428-436. https://doi.org/10.1177/1358863X18763096
Beierfuss, A., Hunjadi, M., Ritsch, A., Kremser, C., Thome, C. and Mern, D.S. (2019) APOE-Knockout in Rabbits Causes Loss of Cells in Nucleus Pulposus and Enhances the Levels of Inflammatory Catabolic Cytokines Damaging the Intervertebral Disc Matrix. PLOS ONE, 14, e0225527. https://doi.org/10.1371/journal.pone.0225527
Lansky, A.J., Dangas, G., Mehran, R., et al. (2002) Quantitative Angiographic Methods for Appropriate End-Point Analysis, Edge-Effect Evaluation, and Prediction of Recurrent Restenosis after Coronary Brachytherapy with Gamma Irradiation. Journal of the American College of Cardiology, 39, 274-280. https://doi.org/10.1016/S0735-1097(01)01745-4
Austen, W.G., Edwards, J.E., Frye, R.L., et al. (1975) A Reporting System on Patients Evaluated for Coronary Artery Disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation, 51, 5-40. https://doi.org/10.1161/01.CIR.51.4.5
CSo, C. (2010) Guideline for Diagnosis and Treatment of Patients with ST-Elevation Myocardial Infarction. Chinese Journal of Cardiology, 8, 675-687.
Hamm, C.W., Bassand, J.P., Agewall, S., et al. (2011) ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation: The Task Force for the Management of Acute Coronary Syndromes (ACS) in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). European Heart Journal, 32, 2999-3054.
Fuster, V., Ryden, L.E., Cannom, D.S., et al. (2006) ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): Developed in Collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 114, e257-e354.
Mohindra, R., Agrawal, D.K. and Thankam, F.G. (2021) Altered Vascular Extracellular Matrix in the Pathogenesis of Atherosclerosis. Journal of Cardiovascular Translational Research, 14, 647-660. https://doi.org/10.1007/s12265-020-10091-8
Gialeli, C., Shami, A. and Goncalves, I. (2021) Extracellular Matrix: Paving the Way to the Newest Trends in Atherosclerosis. Current Opinion in Lipidology, 32, 277-285. https://doi.org/10.1097/MOL.0000000000000775
Katsuda, S. and Kaji, T. (2003) Atherosclerosis and Extracellular Matrix. Journal of Atherosclerosis and Thrombosis, 10, 267-274. https://doi.org/10.5551/jat.10.267
Mead, T.J. and Apte, S.S. (2018) ADAMTS Proteins in Human Disorders. Matrix Biology: Journal of the International Society for Matrix Biology, 71-72, 225-239. https://doi.org/10.1016/j.matbio.2018.06.002
Wang, X. and Khalil, R.A. (2018) Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. Advances in Pharmacology, 81, 241-330. https://doi.org/10.1016/bs.apha.2017.08.002
Kremastiotis, G., Handa, I., Jackson, C., George, S. and Johnson, J. (2021) Disparate Effects of MMP and TIMP Modulation on Coronary Atherosclerosis and Associated Myocardial Fibrosis. Scientific Reports, 11, Article No. 23081. https://doi.org/10.1038/s41598-021-02508-4
Brown, B.A., Williams, H. and George, S.J. (2017) Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis. Progress in Molecular Biology and Translational Science, 147, 197-237. https://doi.org/10.1016/bs.pmbts.2017.01.004
Novak, R., Hrkac, S., Salai, G., Bilandzic, J., Mitar, L. and Grgurevic, L. (2022) The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities. Journal of Vascular Research, 59, 69-77. https://doi.org/10.1159/000521498
Ong, M.H., Wong, H.K., Tengku-Muhammad, T.S., Choo, Q.C. and Chew, C.H. (2019) Pro-Atherogenic Proteoglycanase ADAMTS-1 Is Down-Regulated by Lauric Acid through PI3K and JNK Signaling Pathways in THP-1 Derived Macrophages. Molecular Biology Reports, 46, 2631-2641. https://doi.org/10.1007/s11033-019-04661-6
Wang, Z., Ye, D., Ye, J., Wang, M., Liu, J., et al. (2019) ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. Disease Markers, 2019, Article ID: 6129748. https://doi.org/10.1155/2019/6129748
Fava, M., Barallobre-Barreiro, J., Mayr, U., Lu, R., Didangelos, A., et al. (2018) Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology, 38, 1537-1548. https://doi.org/10.1161/ATVBAHA.117.310562
Wang, T., He, C. (2018) Pro-Inflammatory Cytokines: The Link between Obesity and Osteoarthritis. Cytokine & Growth Factor Reviews, 44, 38-50. https://doi.org/10.1016/j.cytogfr.2018.10.002
Johnson, J.L. (2017) Metalloproteinases in Atherosclerosis. European Journal of Pharmacology, 816, 93-106. https://doi.org/10.1016/j.ejphar.2017.09.007
Tanindi, A., Sahinarslan, A., Elbeg, S. and Cemri, M. (2011) Relationship between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease. The Open Cardiovascular Medicine Journal, 5, 110-116. https://doi.org/10.2174/1874192401105010110
Lahdentausta, L., Leskela, J., Winkelmann, A., et al. (2018) Serum MMP-9 Diagnostics, Prognostics, and Activation in Acute Coronary Syndrome and Its Recurrence. Journal of Cardiovascular Translational Research, 11, 210-220. https://doi.org/10.1007/s12265-018-9789-x
Wei, M., Pan, H. and Guo, K. (2021) Association between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease. Angiology, 72, 371-380. https://doi.org/10.1177/0003319720979238