Research ArticleOpen AccessGoogle Scholar indexed
A Review of Bicuspid Aortic Valve Anomaly
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 1 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 2 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 3 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 4 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 5 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 6 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 7 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 8 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 9 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 10 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
- 11 Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China
International Journal of Clinical Medicine·Volume 16 (2025)·Pages 112–126·Published 9 January 2025·DOI10.4236/ijcm.2025.161007
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Abstract
Bicuspid aortic valve (BAV) is a common congenital heart valve disease, often accompanied by aortic valve stenosis or regurgitation, infective endocarditis, and aortic diseases such as aortic dilation and dissection. This article aims to review the definition, pathogenesis and genetic basis, classification methods, clinical features and current status of research and treatment and prognosis of BAV, and provide reference for the diagnosis and treatment of BAV. The content and structure of this article are as follows: The first part introduces the definition of BAV; The second part introduces the etiology and classification methods of BAV; The third part briefly describes the clinical manifestations and diagnosis of BAV; The fourth part discusses the treatment strategies and prognosis prediction of BAV; Finally, the article summarizes and looks forward to the future research directions.
KeywordsBicuspid Aortic ValveCongenital Heart DiseaseAortic Valve DiseaseTranscatheter Aortic Valve Replacement
- Verma, R., Cohen, G., Colbert, J. and Fedak, P.W.M. (2022) Bicuspid Aortic Valve Associated Aortopathy: 2022 Guideline Update. Current Opinion in Cardiology , 38, 61-67. https://doi.org/10.1097/hco.0000000000001020
- Bravo-Jaimes, K. and Prakash, S.K. (2020) Genetics in Bicuspid Aortic Valve Disease: Where Are We? Progress in Cardiovascular Diseases , 63, 398-406. https://doi.org/10.1016/j.pcad.2020.06.005
- Soto-Navarrete, M.T., López-Unzu, M.Á., Durán, A.C. and Fernández, B. (2020) Embryonic Development of Bicuspid Aortic Valves. Progress in Cardiovascular Diseases , 63, 407-418. https://doi.org/10.1016/j.pcad.2020.06.008
- Bernard, C., Morgant, M.C., Guillier, D., Cheynel, N. and Bouchot, O. (2022) Point on the Aortic Bicuspid Valve. Life , 12, Article 518. https://doi.org/10.3390/life12040518
- Mrsic, Z., Hopkins, S.P., Antevil, J.L. and Mullenix, P.S. (2018) Valvular Heart Disease. Primary Care: Clinics in Office Practice , 45, 81-94. https://doi.org/10.1016/j.pop.2017.10.002
- Niaz, T., Poterucha, J.T., Olson, T.M., Johnson, J.N., Craviari, C., Nienaber, T., et al . (2018) Characteristic Morphologies of the Bicuspid Aortic Valve in Patients with Genetic Syndromes. Journal of the American Society of Echocardiography , 31, 194-200. https://doi.org/10.1016/j.echo.2017.10.008
- Boodhwani, M., de Kerchove, L., Glineur, D., Rubay, J., Vanoverschelde, J., Noirhomme, P., et al . (2010) Repair of Regurgitant Bicuspid Aortic Valves: A Systematic Approach. The Journal of Thoracic and Cardiovascular Surgery , 140, 276-284.E1. https://doi.org/10.1016/j.jtcvs.2009.11.058
- Vincent, F., Ternacle, J., Denimal, T., Shen, M., Redfors, B., Delhaye, C., et al . (2021) Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis. Circulation , 143, 1043-1061. https://doi.org/10.1161/circulationaha.120.048048
- Prakash, S.K., Bossé, Y., Muehlschlegel, J.D., Michelena, H.I., Limongelli, G., Della Corte, A., et al . (2014) A Roadmap to Investigate the Genetic Basis of Bicuspid Aortic Valve and Its Complications: Insights from the International BAVCon (Bicuspid Aortic Valve Consortium). Journal of the American College of Cardiology , 64, 832-839. https://doi.org/10.1016/j.jacc.2014.04.073
- Bulut, H.I., Arjomandi Rad, A., Syrengela, A., Ttofi, I., Djordjevic, J., Kaur, R., et al . (2023) A Comprehensive Review of Management Strategies for Bicuspid Aortic Valve (BAV): Exploring Epidemiology, Aetiology, Aortopathy, and Interventions in Light of Recent Guidelines. Journal of Cardiovascular Development and Disease , 10, Article 398. https://doi.org/10.3390/jcdd10090398