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A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome
Department of Internal Medicine, Hiratsuka City Hospital, Hiratsuka, Japan
2Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan
Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan
Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan
Department of Neurology, National Hakone Hospital, Odawara, Japan
Department of Neurology, Tokai University School of Medicine, Isehara, Japan
- 1 Department of Internal Medicine, Hiratsuka City Hospital, Hiratsuka, Japan
- 2 2Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan
- 3 Department of Neurology, Hiratsuka City Hospital, Hiratsuka, Japan
- 4 Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan
- 5 Department of Neurology, National Hakone Hospital, Odawara, Japan
- 6 Department of Neurology, Tokai University School of Medicine, Isehara, Japan
International Journal of Clinical Medicine·Volume 03 (2012)·Pages 190–193·Published 29 May 2012·DOI10.4236/ijcm.2012.33038
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Abstract
We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM-1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.
KeywordsLower Motor Neuron Syndrome (LMNS)Multifocal Motor Neuropathy (MMN)Localized Proximal Muscle WeaknessIntravenous Immunoglobulin (IVIg)Anti-GM1 Ganglioside Antibody
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