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Pathological Complete Remission in Young Colon Cancer Patient with a Large Liver Metastasis after FOLFOX-4/Bevacizumab Treatment – A Case Report
Pauls Stradins Clinical University Hospital, Riga, Latvia
Hereditary Cancer Institute, Riga Stradins University, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
Hereditary Cancer Institute, Riga Stradins University, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
Pauls Stradins Clinical University Hospital, Riga, Latvia
- 1 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 2 Hereditary Cancer Institute, Riga Stradins University, Riga, Latvia
- 3 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 4 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 5 Hereditary Cancer Institute, Riga Stradins University, Riga, Latvia
- 6 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 7 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 8 Pauls Stradins Clinical University Hospital, Riga, Latvia
- 9 Pauls Stradins Clinical University Hospital, Riga, Latvia
International Journal of Clinical Medicine·Volume 03 (2012)·Pages 307–310·Published 12 July 2012·DOI10.4236/ijcm.2012.34061
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Abstract
Introduction. Pathological complete remission of liver metastases is a rare colon cancer treatment outcome with increased 5-year survival of 76%. Case report. Metastatic colorectal cancer patient with pathological complete remission of large hepatic metastasis after palliative chemotherapy in combination with bevacizumab is presented. Solitary liver metastasis measuring 8 cm was observed in computed tomography (CT) scan before combined treatment. The best radiological response during treatment with FOLFOX-4 and bevacizumab therapy was partial remission and patient underwent partial hepatectomy. Since the operation material was free of viable adenocarcinoma cells the effect of FOLFOX-4 in combination with bevacizumab treatment was interpreted as the pathological complete remission. Conclusion. Use of combination chemotherapy and targeted therapy with the aim to reduce initially unresectable liver metastasis is the best option to achieve complete pathological remission and significantly prolong survival.
KeywordsMetastatic Colorectal CancerPathological Complete RemissionBevacizumab
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