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Dasatinib-Induced Hepatic Dysfunction
Graduate School of Medicine, University of Wollongong, Wollongong, Australia
- 1 Graduate School of Medicine, University of Wollongong, Wollongong, Australia
International Journal of Clinical Medicine·Volume 04 (2013)·Pages 8–9·Published 15 January 2013·DOI10.4236/ijcm.2013.41003
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Abstract
A 53-year-old man with chronic myeloid leukaemia developed significant hepatic dysfunction when treatment was changed from imatinib (because of drug-induced rash) to dasatinib. Liver function tests returned to normal 77 days after cessation of therapy and have remained normal despite recommencement of dasatinib. Although the pathogenesis for the significant hepatic dysfunction is unclear, this case illustrates the reversibility of this event with dose interruption and that dasatinib can be safely recommenced for ongoing treatment.
KeywordsDasatinibHepatic DysfunctionReversibility
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