Melanoma of the Oral Cavity: About Two Cases and Review of Literature
- 1 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 2 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 3 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 4 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 5 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 6 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 7 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 8 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 9 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
- 10 Department of pathology, National Institute of Oncology, Rabat, Morocco
- 11 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
Abstract
Mucosal malignant melanoma of the oral cavity is an extremely rare condition. It has a poor prognosis. Here we report two typical cases of malignant melanoma. In the first case, 64 years old man developed an exophytic tumor in the hard palate. Head and neck and chest computerized tomography scan showed a large aggressive tumor of the hard palate. The patient also had multiple lung metastases and a cervical lymph node. The second case is a 73 years old woman pre senting a burgeoning mass on the right palate. Facial CT reveals a malignant tumor lateralized in the right palate with ipsilateral metastatic lymph nodes. Histological with immunohistochemical studies assigned both cases to a malignant melanoma. Due to the rarity of oral malignant melanomas, case reports are a necessary source of information.
- D. Jackson and H. E. Simpson, “Primary Malignant Melanoma of the Oral Cavity,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 39, No. 6, 1975, pp. 553-559. doi:10.1016/0030-4220(75)90194-2
- N. J. D’Silva, Z. Kurago, P. J. Polverini, C. T. Hanks and A. F. Paulino, “Malignant Melanoma of the Oral Mucosa in a 17-Year-Old Adolescent Girl,” Archives of Pathology & Laboratory Medicine, Vol. 126, No. 9, 2002, pp. 1110-1113.
- R. I. van der Waal, G. B. Snow, A. B. Karim and I. Van der Waal, “Primary Malignant Melanoma of the Oral Cavity: A Review of Eight Cases,” British Dental Journal, Vol. 176, No. 5, 1994, pp. 185-188. doi:10.1038/sj.bdj.4808406
- M. Hashemipour, “Malignant Melanoma of the Oral Cavity,” Journal of Dentistry, Vol. 4, No. 1, 2007, pp. 44-51.
- B. Colllins, E. Leon Barnes Jr. and J. Abernethy, “Oral Malignant Melanoma,” Journal of Clinical Oncology, Vol. 55, 2005, pp. 74-108.
- Bork, Hoede, Korting, Burgdorf and Young, “Diseases of the Oral Mucosa and the Lips,” W. B. Saunders, Philadelphia, 1996, pp. 336-340.
- R. Rajendran and B. Sivapada Sundaram, “Benign and Malignant Tumors of the Oral Cavity,” In: Shafer, Hine and Lavy, Eds., Shafer’s Text Book of Oral Pathology, Elsevier India, 2009, pp. 120-127.
- M. Singh, J. Lin, T. L. Hocker and H. Tsao, “Genetics of Melanoma Tumerogenesis,” British Journal of Dermatology, Vol. 158, No. 1, 2008, pp. 15-21. doi:10.1111/j.1365-2133.2007.08316.x
- A. D. Rapidis, C. Apostolidis, G. Vilos and S. Valsamis, “Primary Malignant Melanoma of the Oral Mucosa,” Journal of Oral and Maxillofacial Surgery, Vol. 61, No. 10, 2003, pp. 1132-1139. doi:10.1016/S0278-2391(03)00670-0
- N. E. Steidler, P. C. Reade and B. G. Radden, “Malignant Melanoma of the Oral Mucosa,” Journal of Oral and Maxillofacial Surgery, Vol. 42, No. 5, 1984, pp. 333-336. doi:10.1016/0278-2391(84)90116-2
- S. R. Prabhu, D. F. Wilson and D. K. Daftary, “Oral Diseases in the Tropics,” Oxford University Press, New York, 1992, pp. 460-461.
- D. Jackson and H. E. Simpson, “Primary Malignant Melanoma of the Oral Cavity,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 39, 1975, pp. 553-559. doi:10.1016/0030-4220(75)90194-2
- N. K. Wood and P. W. Goaz, “Differential Diagnosis of Oral and Maxillofacial Lesions,” 5th Edition, Maryland Heights, 1997, pp. 67-68, 190.