The Expression of NF-κB in the Glomerulus of Hyperlipidemia Rats
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Abstract
Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given with high fat diet and vitamin D3 by intragastric administration. After four weeks, the level of the plasma cholesterol, low density lipoprotein cholesterol (LDLC), MCP-1 and NF-κB were detected by immunohistochemical method and enzyme linked immunosorbent assay (ELISA). Results: The levels of the plasma cholesterol and LDLC were higher than that of the control group. A significant in-crease for the expressions of MCP-1 and NF-κB was observed. Conclusion: This indi-cated that the activation of NF-κB could play a crucial role in glomerulus of hyperlipidemia rats.
- J. L. Beaumont, L. A. Carlson, G. R. Cooper, Z. Fejfar, D. S. Fredrickson and T. Strasser, “Classification of Hyperlipidaemias and Hyperlipoproteinaemias,” Bull World Health Organ, Vol. 43, No. 6, 1970, pp. 891-915.
- D. S. Fredrickson, R. I. Levy and R. S. Lees, “Fat Transport in Lipoproteins—An Integrated Approach to Mechanisms and Disorders,” New England Journal of Medicine, Vol. 276, No. 5, 1967, pp. 273-281. doi:10.1056/NEJM196702022760507
- R. J. Havel, “Pathogenesis, Differentiation and Management of Hypertriglyceridemia,” Advances in Internal Medicine, Vol. 15, 1969, pp. 117-154.
- A. D. Schachter, J. Strehlau, D. Zurakowski, et al., “Increased Nuclear Factor-KappaB and Angiotensinogen Gene Expression in Posttransplant Recurrent Focal Segmental Glomerulosclerosis,” Transplantation, Vol. 70, No. 7, 2000, pp. 1107-1110. doi:10.1097/00007890-200010150-00021
- C. C. Yu, C. W. Yang, M. S. Wu, et al., “Mycophenolatemofetil Reduces Renal Cortical Inducible Nitric Oxide Synthase mRNA Expression and Diminishes Glomerulosclerosis in MRL//pr Mice,” Journal of Laboratory and Clinical Medecine, Vol. 138, No. 1, 2001, pp. 69-77. doi:10.1067/mlc.2001.115647
- F. Zheng, Q. L. Cheng, A. R. Plati, et al., “The Glomerulosclerosis of Aging in Females: Contribution of the Proinflammatorymesangial Cell Phenotype to Macrophage Infiltration,” American Journal of Pathology, Vol. 165, No. 5, 2004, pp. 1789-1798. doi:10.1016/S0002-9440(10)63434-7
- A. Yamamoto, A. Kawaguchi, M. Harada-Shiba, M. Tsushima and S. Kojima, “Apheresis Technology for Prevention and Regression of Atherosclerosis: An Overview,” Therapeutic Apheresis, Vol. 1, No. 3, 1997, pp. 233-241. doi:10.1111/j.1744-9987.1997.tb00144.x
- A. Hoffmann and D. Baltimore, “Circuitry of Nuclear Factor Kappa B Signaling,” Immunological Reviews, Vol. 210, No. 4, 2006, pp. 171-86. doi:10.1111/j.0105-2896.2006.00375.x
- K. W. Walton, “Fat Transport by Lipoproteins in Health and Disease,” Journal of Atherosclerosis Research, Vol. 7, No. 5, 1967, pp. 533-536. doi:10.1016/S0368-1319(67)80031-0
- D. X. Qin, X. Zou, W. Luo, et al., “Expression of Some Neurotrophins in the Spinal Motoneurons after Cord Hemisection in Adult Rats,” Neuroscience letters, Vol. 410, No. 3, 2006, pp. 222-227. doi:10.1016/j.neulet.2006.10.006
- J. Morrissey and S. Klahr, “Transcription Factor NF-KappaB Regulation of Renal Fibrosis during Ureteral Obstruction,” Seminars in Nephrology, Vol. 18, No. 6, 1998, pp. 603-611.