Experience of Patients Undergoing Mini-Arthroscopy Compared to MRI in the Earliest Phases of Arthritis
- 1 Department of Clinical Immunology and Rheumatology, Aca-demic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 2 Department of Clinical Immunology and Rheumatology, Aca-demic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 3 Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 4 Department of Clinical Immunology and Rheumatology, Aca-demic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 5 Department of Clinical Immunology and Rheumatology, Aca-demic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Abstract
Objective : To evaluate the expectations and experience of patients undergoing mini-arthroscopy compared to contrast enhanced MRI for research purposes. Methods : Seventeen patients with early, active arthritis (Group A) and 21 autoan tibody-positive individuals without any evidence of arthritis upon physical examination (Group B) were included. All subjects underwent both contrast enhanced MRI and synovial biopsy sampling by mini-arthroscopy of the same joint within one week. At inclusion and after both procedures, subjects filled in questionnaires with items about expectations and experience with regard to the procedures. Results : Before procedures , s ubjects in group B had a higher fear of and reluctance to undergo mini-arthroscopy compared to MRI (p < 0.0001 and p = 0.001, respectively). Before procedures , 42% of the subjects preferred MRI, 11% of the subjects preferred mini-arthroscopy and 47% had no preference for ei ther procedure. After both procedures , subjects preferences changed to 39% for MRI, 32% for mini-arthroscopy and 29% for no preference for one or the other procedure. When comparing Group A with Group B, there were no signif i cant differences in preference before and after the procedures. Conclusion : Synovial biopsy sampling by mini-arthro scopy for analysis of synovial inflammation is a well-experienced procedure when compared to contrast enhanced MRI. These results support the use of mini-arthroscopy in a research setting from a patient perspective.
- P. P. Tak and B. Bresnihan, “The Pathogenesis and Prevention of Joint Damage in Rheumatoid Arthritis: Advances from Synovial Biopsy and Tissue Analysis,” Arthritis & Rheumatism, Vol. 43, No. 12, 2000, pp. 2619-2633. http://dx.doi.org/10.1002/1529-0131(200012)43:12 3.0.CO;2-V
- D. M. Gerlag and P. P. Tak, “How to Perform and Analyse Synovial Biopsies,” Best Practice & Research Clinical Rheumatology, Vol. 23, No. 2, 2009, pp. 221-232. http://dx.doi.org/10.1016/j.berh.2009.01.006
- D. Kane, D. J. Veale, O. Fitzgerald, et al., “Survey of Arthroscopy Performed by Rheumatologists,” Rheumatology (Oxford), Vol. 41, No. 2, 2002, pp. 210-215. http://dx.doi.org/10.1093/rheumatology/41.2.210
- S. Vordenbaumen, L. A. Joosten, J. Friemann, et al., “Utility of Synovial Biopsy,” Arthritis Research & Therapy, Vol. 11, 2009, p. 256. http://dx.doi.org/10.1186/ar2847
- M. B. Axelsen, M. Stoltenberg, R. P. Poggenborg, et al., “Dynamic Gadolinium-Enhanced Magnetic Resonance Imaging Allows Accurate Assessment of the Synovial Inflammatory Activity in Rheumatoid Arthritis Knee Joints: A Comparison with Synovial Histology,” Scandinavian Journal of Rheumatology, Vol. 41, No. 2, 2012, pp. 89-94. http://dx.doi.org/10.3109/03009742.2011.608375
- C. van der Leij, M. G. van de Sande and C. Lavini, et al., “Rheumatoid Synovial Inflammation: Pixel-by-Pixel Dynamic Contrast-Enhanced MR Imaging Time-Intensity Curve Shape Analysis—A Feasibility Study,” Radiology, Vol. 253, No. 1, 2009, pp. 234-240. http://dx.doi.org/10.1148/radiol.2531081722
- M. Navalho, C. Resende, A. M. Rodrigues, et al., “Dynamic Contrast-Enhanced 3-T Magnetic Resonance Imaging: A Method for Quantifying Disease Activity in Early Polyarthritis,” Skeletal Radiology, Vol. 41, No. 1, 2012, pp. 51-59. http://dx.doi.org/10.1007/s00256-011-1112-8
- B. Ejbjerg, E. Narvestad, E. Rostrup, et al., “Magnetic Resonance Imaging of Wrist and Finger Joints in Healthy Subjects Occasionally Shows Changes Resembling Erosions and Synovitis as Seen in Rheumatoid Arthritis,” Arthritis & Rheumatism, Vol. 50, 2004, pp. 1097-1106. http://dx.doi.org/10.1002/art.20135
- M. Ostergaard, I. Lorenzen and O. Henriksen, “Dynamic Gadolinium-Enhanced MR Imaging in Active and Inactive Immunoinflammatory Gonarthritis,” Acta Radiologica, Vol. 35, No. 3, 1994, pp. 275-281.
- M. Ostergaard, M. Stoltenberg, P. Lovgreen-Nielsen, et al., “Quantification of Synovistis by MRI: Correlation between Dynamic and Static Gadolinium-Enhanced Magnetic Resonance Imaging and Microscopic and Macroscopic Signs of Synovial Inflammation,” Magnetic Resonance Imaging, Vol. 16, No. 7, 1998, pp. 743-754. http://dx.doi.org/10.1016/S0730-725X(98)00008-3