The Application and Indications for Sentinel Lymph Node Biopsy in Pediatric Solid Tumors: Current Status and Future Directions — Oak Academic Publishing
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The Application and Indications for Sentinel Lymph Node Biopsy in Pediatric Solid Tumors: Current Status and Future Directions
Department of Surgery, St. Jude Children’s Research Hospital, Memphis, USA
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Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
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Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
1 Department of Surgery, St. Jude Children’s Research Hospital, Memphis, USA
2 Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
3 Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
Oncologic staging of many solid organ malignancies involves an understanding of how cancers spread via the lymphatic system, and ultimately may involve evaluation of the primary nodal drainage basin by performing a sentinel lymph node biopsy. In the adult population, there are well established indications for sentinel lymph node biopsy in diseases like melanoma and breast cancer. However, its use and relevance in the pediatric population is less defined. This review details the history and development of sentinel lymph node biopsy technique, advanced lymph node mapping techniques currently under investigation, and the applications of sentinel node biopsy towards childhood cancers.
Seaman, W.B. and Powers, W.E. (1955) Studies on the Distribution of Radioactive Colloidal Gold in Regional Lymph Nodes Containing Cancer. Cancer, 8, 1044-1046. http://dx.doi.org/10.1002/1097-0142(1955)8:5 3.0.CO;2-6
Gould, E.A., Winship, T., Philbin, P.H. and Kerr, H.H. (1960) Observations on a “Sentinel Node” in Cancer of the Parotid. Cancer, 13, 77-78. http://dx.doi.org/10.1002/1097-0142(196001/02)13:1 3.0.CO;2-D
Morton, D.L., Wen, D.R., Wong, J.H., Economou, J.S., Cagle, L.A., Storm, F.K., et al. (1992) Technical Details of Intraoperative Lymphatic Mapping for Early Stage Melanoma. Archives of Surgery, 127, 392-399. http://dx.doi.org/10.1001/archsurg.1992.01420040034005
Morton, D.L., Thompson, J.F., Essner, R., Elashoff, R., Stern, S.L., Nieweg, O.E., et al. (1999) Validation of the Accuracy of Intraoperative Lymphatic Mapping and Sentinel Lymphadenectomy for Early-Stage Melanoma: A Multicenter Trial. Multicenter Selective Lymphadenectomy Trial Group. Annals of Surgery, 230, 453-463. http://dx.doi.org/10.1097/00000658-199910000-00001
Pijpers, R., Collet, G.J., Meijer, S. and Hoekstra, O.S. (1995) The Impact of Dynamic Lymphoscintigraphy and Gamma Probe Guidance on Sentinel Node Biopsy in Melanoma. European Journal of Nuclear Medicine and Molecular Imaging, 22, 1238-1241. http://dx.doi.org/10.1007/BF00801606
Giuliano, A.E., Dale, P.S., Turner, R.R., Morton, D.L., Evans, S.W. and Krasne, D.L. (1995) Improved Axillary Staging of Breast Cancer with Sentinel Lymphadenectomy. Annals of Surgery, 222, 394-399. http://dx.doi.org/10.1097/00000658-199509000-00016
Hamy, A., Curtet, C., Paineau, J., Chatal, J.F. and Visset, J. (1995) Feasibility of Radioimmunoguided Surgery of Colorectal Carcinoma Using Indium 111 CEA Specific Antibody and Simulation with a Phantom Using 2 Steps Targetting with Bispecific Antibody. Tumori, 81, 103-106.
Levenback, C., Burke, T.W., Morris, M., Malpica, A., Lucas, K.R. and Gershenson, D.M. (1995) Potential Applications of Intraoperative Lymphatic Mapping in Vulvar Cancer. Gynecologic Oncology, 59, 216-220. http://dx.doi.org/10.1006/gyno.1995.0011
Parida, L., Morrisson, G.T., Shammas, A., Hossain, A.K., McCarville, M.B., Gerstle, J.T., et al. (2012) Role of Lymphoscintigraphy and Sentinel Lymph Node Biopsy in the Management of Pediatric Melanoma and Sarcoma. Pediatric Surgery International, 28, 571-578. http://dx.doi.org/10.1007/s00383-012-3066-x
Howman-Giles, R., Shaw, H.M., Scolyer, R.A., Murali, R., Wilmott, J., McCarthy, S.W., et al. (2010) Sentinel Lymph Node Biopsy in Pediatric and Adolescent Cutaneous Melanoma Patients. Annals of Surgical Oncology, 17, 138-143. http://dx.doi.org/10.1245/s10434-009-0657-4
Toro, J., Ranieri, J.M., Havlik, R.J., Coleman III, J.J. and Wagner, J.D. (2003) Sentinel Lymph Node Biopsy in Children and Adolescents with Malignant Melanoma. Journal of Pediatric Surgery, 38, 1063-1065. http://dx.doi.org/10.1016/S0022-3468(03)00193-3
Gibbs, P., Moore, A., Robinson, W., Walsh, P., Golitz, L. and Gonzalez, R. (2000) Pediatric Melanoma: Are Recent Advances in the Management of Adult Melanoma Relevant to the Pediatric Population. Journal of Pediatric Hematology/Oncology, 22, 428-432. http://dx.doi.org/10.1097/00043426-200009000-00008
Kayton, M.L. and La Quaglia, M.P. (2008) Sentinel Node Biopsy for Melanocytic Tumors in Children. Seminars in Diagnostic Pathology, 25, 95-99. http://dx.doi.org/10.1053/j.semdp.2008.05.001
Neville, H.L., Andrassy, R.J., Lally, K.P., Corpron, C. and Ross, M.I. (2000) Lymphatic Mapping with Sentinel Node Biopsy in Pediatric Patients. Journal of Pediatric Surgery, 35, 961-964. http://dx.doi.org/10.1053/jpsu.2000.6936
Gow, K.W., Rapkin, L.B., Olson, T.A., Durham, M.M., Wyly, B. and Shehata, B.M. (2008) Sentinel Lymph Node Biopsy in the Pediatric Population. Journal of Pediatric Surgery, 43, 2193-2198. http://dx.doi.org/10.1016/j.jpedsurg.2008.08.063
De Corti, F., Dall’Igna, P., Bisogno, G., Casara, D., Rossi, C.R., Foletto, M., et al. (2009) Sentinel Node Biopsy in Pediatric Soft Tissue Sarcomas of Extremities. Pediatric Blood & Cancer, 52, 51-54. http://dx.doi.org/10.1002/pbc.21777
Kayton, M.L., Delgado, R., Busam, K., Cody III, H.S., Athanasian, E.A., Coit, D. and La Quaglia, M.P. (2008) Experience with 31 Sentinel Lymph Node Biopsies for Sarcomas and Carcinomas in Pediatric Patients. Cancer, 112, 2052-2059. http://dx.doi.org/10.1002/cncr.23403
Gilchrist, R.K. (1940) Fundamental Factors Governing Lymphatic of Carcinoma. Annals of Surgery, 111, 630-639. http://dx.doi.org/10.1097/00000658-194004000-00014
Zeidman, I. and Buss, J.M. (1954) Experimental Studies on the Spread of Cancer in the Lymphatic System. I. Effectiveness of the Lymph Node as a Barrier to the Passage of Embolic Tumor Cells. Cancer Research, 14, 403-405.
Cabanas, R.M. (1977) An Approach for the Treatment of Penile Carcinoma. Cancer, 39, 456-466. http://dx.doi.org/10.1002/1097-0142(197702)39:2 3.0.CO;2-I
Burke, T.W., Levenback, C., Tornos, C., Morris, M., Wharton, J.T. and Gershenson, D.M. (1996) Intraabdominal Lymphatic Mapping to Direct Selective Pelvic and Paraaortic Lymphadenectomy in Women with High-Risk Endometrial Cancer: Results of a Pilot Study. Gynecologic Oncology, 62, 169-173. http://dx.doi.org/10.1006/gyno.1996.0211
Kelemen, P.R., Van Herle, A.J. and Giuliano, A.E. (1998) Sentinel Lymphadenectomy in Thyroid Malignant Neoplasms. JAMA Surgery, 133, 288-292. http://dx.doi.org/10.1001/archsurg.133.3.288
Giuliano, A.E., Kirgan, D.M., Guenther, J.M. and Morton, D.L. (1994) Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer. Annals of Surgery, 220, 391-398. http://dx.doi.org/10.1097/00000658-199409000-00015
Krag, D.N., Weaver, D.L., Alex, J.C. and Fairbank, J.T. (1993) Surgical Resection and Radiolocalization of the Sentinel Lymph Node in Breast Cancer Using a Gamma Probe. Surgical Oncology, 2, 335-339. http://dx.doi.org/10.1016/0960-7404(93)90064-6
Krag, D., Weaver, D., Ashikaga, T., Moffat, F., Klimberg, V.S., Shriver, C., et al. (1998) The Sentinel Node in Breast Cancer—A Multicenter Validation Study. New England Journal of Medicine, 339, 941-946. http://dx.doi.org/10.1056/NEJM199810013391401
Albertini, J.J., Lyman, G.H., Cox, C., Yeatman, T., Balducci, L., Ku, N., et al. (1996) Lymphatic Mapping and Sentinel Node Biopsy in the Patient with Breast Cancer. JAMA, 276, 1818-1822. http://dx.doi.org/10.1001/jama.1996.03540220042028
Mcmasters, K.M., Tuttle, T.M., Carlson, D.J., Brown, C.M., Noyes, R.D., Glaser, R.L., et al. (2000) Sentinel Lymph Node Biopsy for Breast Cancer: A Suitable Alternative to Routine Axillary Dissection in Multi-Institutional Practice When Optimal Technique Is Used. Journal of Clinical Oncology, 18, 2560-2566.
Stanley, A., William, C., Herbert, C. and Gregory, J. (2014) Lymphatic Mapping and Sentinel Nodes Biopsy. In: Stanley, A., William, C., Herbert, C. and Gregory, J., Eds., ACS Surgery: Principles and Practice, B.C. Decker, Inc., Ontario.
Morton, D.L., Cochran, A.J., Thompson, J.F., Elashoff, R., Essner, R., Glass, E.C., et al. (2005) Sentinel Node Biopsy for Early-Stage Melanoma: Accuracy and Morbidity in MSLT-I, an International Multicenter Trial. Annals of Surgery, 242, 302-311.
Thompson, J.F. and Uren, R.F. (2005) Lymphatic Mapping in Management of Patients with Primary Cutaneous Melanoma. Lancet Oncology, 6, 877-885. http://dx.doi.org/10.1016/S1470-2045(05)70423-X
Vitali, G.C., Trifiro, G., Zonta, M., Pennacchioli, E., Santoro, L., Travaini, L.L., Barberis, M. and Testori, A. (2014) Lymphoscintigraphy in Clinical Routine Practice: Reproducibility and Accuracy in Melanoma Patients with a Long-Term Follow-Up. European Journal of Surgical Oncology, 40, 55-60. http://dx.doi.org/10.1016/j.ejso.2013.09.003
Morton, D.L. (1997) Sentinel Lymphadenectomy for Patients with Clinical Stage I Melanoma. Journal of Surgical Oncology, 66, 267-269. http://dx.doi.org/10.1002/(SICI)1096-9098(199712)66:4 3.0.CO;2-9
Camp, M. and Smith, B. (2013) Lymphatic Mapping and Sentinel Lymphadenectomy. In: Cameron, J. and Cameron, A., Eds., Current Surgical Therapy, Saunders, 592-595.
Stitzenberg, K.B., Calvo, B.F., Iacocca, M.V., Neelon, B.H., Sansbury, L.B., Dressler, L.G. and Ollila, D.W. (2002) Cytokeratin Immunohistochemical Validation of the Sentinel Node Hypothesis in Patients with Breast Cancer. American Journal of Clinical Pathology, 117, 729-737.
Cochran, A. (2012) Sentinel Lymph Node Biopsies. In: Calonje, E., Brenn, T. and Lazar, A., Eds., Mckee’s Pathology of the Skin, with Clinical Correlations, Saunders, 1296-1309.
Wrightson, W.R., Wong, S.L., Edwards, M.J., Chao, C., Reintgen, D.S., Ross, M.I., et al. (2003) Complications Associated with Sentinel Lymph Node Biopsy for Melanoma. Annals of Surgical Oncology, 10, 676-680. http://dx.doi.org/10.1245/ASO.2003.10.001
Simmons, R., Thevarajah, S., Brennan, M.B., Christos, P. and Osborne, M. (2003) Methylene Blue Dye as an Alternative to Isosulfan Blue Dye for Sentinel Lymph Node Localization. Annals of Surgical Oncology, 10, 242-247. http://dx.doi.org/10.1245/ASO.2003.04.021
Aydogan, F., Celik, V., Uras, C., Salihoglu, Z. and Topuz, U. (2008) A Comparison of the Adverse Reactions Associated with Isosulfan Blue versus Methylene Blue Dye in Sentinel Lymph Node Biopsy for Breast Cancer. American Journal of Surgery, 195, 277-278. http://dx.doi.org/10.1016/j.amjsurg.2007.03.008
Wahid, F., Malkan, A., Pappo, A., Wright, B., Adefeyisan, S. and Sandoval, J. (2014) Severe Anaphylactic Shock Due to Methylene Blue Dye. Journal of Pediatric Surgery Case Reports, 2, 117-118. http://dx.doi.org/10.1016/j.epsc.2014.02.009
Spanheimer, P.M., Graham, M.M., Sugg, S.L., Scott-Conner, C.E. and Weigel, R.J. (2009) Measurement of Uterine Radiation Exposure from Lymphoscintigraphy Indicates Safety of Sentinel Lymph Node Biopsy during Pregnancy. Annals of Surgical Oncology, 16, 1143-1147. http://dx.doi.org/10.1245/s10434-009-0390-z
Morton, D.L., Thompson, J.F., Cochran, A.J., Mozzillo, N., Elashoff, R., Essner, R., et al. (2006) Sentinel-Node Biopsy or Nodal Observation in Melanoma. New England Journal of Medicine, 355, 1307-1317. http://dx.doi.org/10.1056/NEJMoa060992
Tausch, C., Baege, A. and Rageth, C. (2014) Mapping Lymph Nodes in Cancer Management—Role of 99mTc-Tilmanocept Injection. OncoTargets and Therapy, 7, 1151-1158. http://dx.doi.org/10.2147/OTT.S50394
Sevick-Muraca, E.M., Kwon, S. and Rasmussen, J.C. (2014) Emerging Lymphatic Imaging Technologies for Mouse and Man. Journal of Clinical Investigation, 124, 905-914. http://dx.doi.org/10.1172/JCI71612
Sondak, V.K., Wong, S.L., Gershenwald, J.E. and Thompson, J.F. (2013) Evidence-Based Clinical Practice Guidelines on the Use of Sentinel Lymph Node Biopsy in Melanoma. American Society of Clinical Oncology Educational Book, E320.
Aldrink, J.H., Selim, M.A., Diesen, D.L., Johnson, J., Pruitt, S.K., Tyler, D.S. and Seigler, H.F. (2009) Pediatric Melanoma: A Single-Institution Experience of 150 Patients. Journal of Pediatric Surgery, 44, 1514-1521. http://dx.doi.org/10.1016/j.jpedsurg.2008.12.003
Pappo, A.S. (2003) Melanoma in Children and Adolescents. European Journal of Cancer, 39, 2651-2661. http://dx.doi.org/10.1016/j.ejca.2003.06.001
National Cancer Institute at the National Institutes of Health. Melanoma Treatment (PDQ®). http://www.cancer.gov
National Comprehensive Cancer Network. Melanoma. www.nccn.org
Wong, S.L., Balch, C.M., Hurley, P., Agarwala, S.S., Akhurst, T.J., Cochran, A., et al. (2012) Sentinel Lymph Node Biopsy for Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Joint Clinical Practice Guideline. Journal of Clinical Oncology, 30, 2912-2918. http://dx.doi.org/10.1200/JCO.2011.40.3519
Mozzillo, N., Pennacchioli, E., Gandini, S., Caracò, C., Crispo, A., Botti, G., et al. (2013) Sentinel Node Biopsy in Thin and Thick Melanoma. Annals of Surgical Oncology, 20, 2780-2786. http://dx.doi.org/10.1245/s10434-012-2826-0
Balch, C.M., Gershenwald, J.E., Soong, S.J., Thompson, J.F., Atkins, M.B., Byrd, D.R., et al. (2009) Final Version of 2009 AJCC Melanoma Staging and Classification. Journal of Clinical Oncology, 27, 6199-6206. http://dx.doi.org/10.1200/JCO.2009.23.4799
Han, D., Zager, J.S., Han, G., Marzban, S.S., Puleo, C.A., Sarnaik, A.A., Reed, D., Messina, J.L. and Sondak, V.K. (2012) The Unique Clinical Characteristics of Melanoma Diagnosed in Children. Annals of Surgical Oncology, 19, 3888-3895. http://dx.doi.org/10.1245/s10434-012-2554-5
Han, D., Yu, D., Zhao, X., Marzban, S.S., Messina, J.L., Gonzalez, R.J., et al. (2012) Sentinel Node Biopsy Is Indicated for Thin Melanomas ≥0.76 mm. Annals of Surgical Oncology, 19, 3335-3342. http://dx.doi.org/10.1245/s10434-012-2469-1
Mu, E., Lange, J.R. and Strouse, J.J. (2012) Comparison of the Use and Results of Sentinel Lymph Node Biopsy in Children and Young Adults with Melanoma. Cancer, 118, 2700-2707. http://dx.doi.org/10.1002/cncr.26578
Bütter, A., Hui, T., Chapdelaine, J., Beaunoyer, M., Flageole, H. and Bouchard, S. (2005) Melanoma in Children and the Use of Sentinel Lymph Node Biopsy. Journal of Pediatric Surgery, 40, 797-800. http://dx.doi.org/10.1016/j.jpedsurg.2005.01.045
Shah, N.C., Gerstle, J.T., Stuart, M., Winter, C. and Pappo, A. (2006) Use of Sentinel Lymph Node Biopsy and High-Dose Interferon in Pediatric Patients with High-Risk Melanoma: The Hospital for Sick Children Experience. Journal of Pediatric Hematology/Oncology, 28, 496-500. http://dx.doi.org/10.1097/01.mph.0000212973.28996.e4
Roaten, J.B., Partrick, D.A., Bensard, D., Pearlman, N., Gonzalez, R., Fitzpatrick, J. and Mccarter, M.D. (2005) Survival in Sentinel Lymph Node-Positive Pediatric Melanoma. Journal of Pediatric Surgery, 40, 988-992. http://dx.doi.org/10.1016/j.jpedsurg.2005.03.014
Roaten, J.B., Partrick, D.A., Pearlman, N., Gonzalez, R.J., Gonzalez, R. and McCarter, M.D. (2005) Sentinel Lymph Node Biopsy for Melanoma and Other Melanocytic Tumors in Adolescents. Journal of Pediatric Surgery, 40, 232-235. http://dx.doi.org/10.1016/j.jpedsurg.2004.09.022
Kogut, K.A., Fleming, M., Pappo, A.S. and Schropp, K.P. (2000) Sentinel Lymph Node Biopsy for Melanoma in Young Children. Journal of Pediatric Surgery, 35, 965-966. http://dx.doi.org/10.1053/jpsu.2000.6937
Topar, G. and Zelger, B. (2007) Assessment of Value of the Sentinel Lymph Node Biopsy in Melanoma in Children and Adolescents and Applicability of Subcutaneous Infusion Anesthesia. Journal of Pediatric Surgery, 42, 1716-1720. http://dx.doi.org/10.1016/j.jpedsurg.2007.05.028
Ferrari, A., Bisogno, G., Cecchetto, G., Santinami, M., Maurichi, A., Bono, A., et al. (2014) Cutaneous Melanoma in Children and Adolescents: The Italian Rare Tumors in Pediatric Age Project Experience. Journal of Pediatrics, 164, 376-382.
Raval, M.V., Bilimoria, K.Y., Bentrem, D.J., Stewart, A.K., Ko, C.Y., Reynolds, M. and Wayne, J.D. (2010) Use of Sentinel Lymph Node Biopsy for Melanoma in Children and Adolescents. Journal of Surgical Oncology, 102, 634-639. http://dx.doi.org/10.1002/jso.21683
Strouse, J.J., Fears, T.R., Tucker, M.A. and Wayne, A.S. (2005) Pediatric Melanoma: Risk Factor and Survival Analysis of the Surveillance, Epidemiology and End Results Database. Journal of Clinical Oncology, 23, 4735-4741. http://dx.doi.org/10.1200/JCO.2005.02.899
Moore-Olufemi, S., Herzog, C., Warneke, C., Gershenwald, J.E., Mansfield, P., Ross, M., Prieto, V., Lally, K.P. and Hayes-Jordan, A. (2011) Outcomes in Pediatric Melanoma: Comparing Prepubertal to Adolescent Pediatric Patients. Annals of Surgery, 253, 1211-1215. http://dx.doi.org/10.1097/SLA.0b013e318217e852
Paradela, S., Fonseca, E., Pita-Fernández, S., Kantrow, S.M., Diwan, A.H., Herzog, C. and Prieto, V.G. (2010) Prognostic Factors for Melanoma in Children and Adolescents: A Clinicopathologic, Single-Center Study of 137 Patients. Cancer, 116, 4334-4344.
Chao, C., Martin, R.C., Ross, M.I., Reintgen, D.S., Edwards, M.J., Noyes, R.D., et al. (2004) Correlation between Prognostic Factors and Increasing Age in Melanoma. Annals of Surgical Oncology, 11, 259-264. http://dx.doi.org/10.1245/ASO.2004.04.015
Livestro, D.P., Kaine, E.M., Michaelson, J.S., Mihm, M.C., Haluska, F.G., Muzikansky, A., Sober, A.J. and Tanabe, K.K. (2007) Melanoma in the Young: Differences and Similarities with Adult Melanoma: A Case-Matched Controlled Analysis. Cancer, 110, 614-624. http://dx.doi.org/10.1002/cncr.22818
Crotty, K.A., Scolyer, R.A., Li, L., Palmer, A.A., Wang, L. and Mccarthy, S.W. (2002) Spitz Naevus versus Spitzoid Melanoma: When and How Can They Be Distinguished? Pathology, 34, 6-12. http://dx.doi.org/10.1080/00313020120111212-1
Barnhill, R.L., Argenyi, Z.B., From, L., Glass, L.F., Maize, J.C., Mihm Jr., M.C., Rabkin, M.S., Ronan, S.G., White, W.L. and Piepkorn, M. (1999) Atypical Spitz Nevi/Tumors: Lack of Consensus for Diagnosis, Discrimination from Melanoma, and Prediction of Outcome. Human Pathology, 30, 513-520. http://dx.doi.org/10.1016/S0046-8177(99)90193-4
Tom, W.L., Hsu, J.W., Eichenfield, L.F. and Friedlander, S.F. (2011) Pediatric “STUMP” Lesions: Evaluation and Management of Difficult Atypical Spitzoid Lesions in Children. Journal of the American Academy of Dermatology, 64, 559-572. http://dx.doi.org/10.1016/j.jaad.2009.12.063
Miteva, M. and Lazova, R. (2010) Spitz Nevus and Atypical Spitzoid Neoplasm. Seminars in Cutaneous Medicine and Surgery, 29, 165-173. http://dx.doi.org/10.1016/j.sder.2010.06.003
Wititsuwannakul, J., Mason, A.R., Klump, V.R. and Lazova, R. (2013) Neuropilin-2 as a Useful Marker in the Differentiation between Spitzoid Malignant Melanoma and Spitz Nevus. Journal of the American Academy of Dermatology, 68, 129-137. http://dx.doi.org/10.1016/j.jaad.2012.07.009
Paradela, S., Fonseca, E., Pita-Fernández, S. and Prieto, V.G. (2013) Spitzoid and Non-Spitzoid Melanoma in Children: A Prognostic Comparative Study. Journal of the European Academy of Dermatology and Venereology, 27, 1214-1221.
Kelley, S.W. and Cockerell, C.J. (2000) Sentinel Lymph Node Biopsy as an Adjunct to Management of Histologically Difficult to Diagnose Melanocytic Lesions: A Proposal. Journal of the American Academy of Dermatology, 42, 527-530. http://dx.doi.org/10.1016/S0190-9622(00)90236-6
Lohmann, C.M., Iversen, K., Jungbluth, A.A., Berwick, M. and Busam, K.J. (2002) Expression of Melanocyte Differentiation Antigens and Ki-67 in Nodal Nevi and Comparison of Ki-67 Expression with Metastatic Melanoma. American Journal of Surgical Pathology, 26, 1351-1357. http://dx.doi.org/10.1097/00000478-200210000-00012
Ludgate, M.W., Fullen, D.R., Lee, J., Lowe, L., Bradford, C., Geiger, J., Schwartz, J. and Johnson, T.M. (2009) The Atypical Spitz Tumor of Uncertain Biologic Potential: A Series of 67 Patients from a Single Institution. Cancer, 115, 631-641. http://dx.doi.org/10.1002/cncr.24047
Kim, J.Y., Choi, J.E., Ahn, H.H., Kye, Y.C. and Seo, S.H. (2012) A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child. Journal of Korean Medical Science, 27, 454-457. http://dx.doi.org/10.3346/jkms.2012.27.4.454
Kamino, H. (2009) Spitzoid Melanoma. Clinics in Dermatology, 27, 545-555. http://dx.doi.org/10.1016/j.clindermatol.2008.09.013
Murali, R., Sharma, R.N., Thompson, J.F., Stretch, J.R., Lee, C.S., Mccarthy, S.W. and Scolyer, R.A. (2008) Sentinel Lymph Node Biopsy in Histologically Ambiguous Melanocytic Tumors with Spitzoid Features (So-Called Atypical Spitzoid Tumors). Annals of Surgical Oncology, 15, 302-309. http://dx.doi.org/10.1245/s10434-007-9577-3
Paradela, S., Fonseca, E., Pita, S., Kantrow, S.M., Goncharuk, V.N., Diwan, H. and Prieto, V.G. (2009) Spitzoid Melanoma in Children: Clinicopathological Study and Application of Immunohistochemistry as an Adjunct Diagnostic Tool. Journal of Cutaneous Pathology, 36, 740-752. http://dx.doi.org/10.1111/j.1600-0560.2008.01153.x
Busam, K.J., Murali, R., Pulitzer, M., Mccarthy, S.W., Thompson, J.F., Shaw, H.M., et al. (2009) Atypical Spitzoid Melanocytic Tumors with Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison with Histologically Unambiguous and Lethal Melanomas. American Journal of Surgical Pathology, 33, 1386-1395. http://dx.doi.org/10.1097/PAS.0b013e3181ac1927
Busam, K.J. and Pulitzer, M. (2008) Sentinel Lymph Node Biopsy for Patients with Diagnostically Controversial Spitzoid Melanocytic Tumors? Advances in Anatomic Pathology, 15, 253-262. http://dx.doi.org/10.1097/PAP.0b013e31818323ac
Spatz, A., Calonje, E., Handfield-Jones, S. and Barnhill, R.L. (1999) Spitz Tumors in Children: A Grading System for Risk Stratification. Archives of Dermatology, 135, 282-285. http://dx.doi.org/10.1001/archderm.135.3.282
Sepehr, A., Chao, E., Trefrey, B., Blackford, A., Duncan, L.M., Flotte, T.J., et al. (2011) Long-Term Outcome of Spitz-Type Melanocytic Tumors. Archives of Dermatology, 147, 1173-1179. http://dx.doi.org/10.1001/archdermatol.2011.170
Gamblin, T.C., Edington, H., Kirkwood, J.M. and Rao, U.N. (2006) Sentinel Lymph Node Biopsy for Atypical Melanocytic Lesions with Spitzoid Features. Annals of Surgical Oncology, 13, 1664-1670. http://dx.doi.org/10.1245/s10434-006-9142-5
Urso, C., Borgognoni, L., Saieva, C., Ferrara, G., Tinacci, G., Begliomini, B. and Reali, U.M. (2006) Sentinel Lymph Node Biopsy in Patients with “Atypical Spitz Tumors.” A Report on 12 Cases. Human Pathology, 37, 816-823. http://dx.doi.org/10.1016/j.humpath.2006.02.001
Su, L.D., Fullen, D.R., Sondak, V.K., Johnson, T.M. and Lowe, L. (2003) Sentinel Lymph Node Biopsy for Patients with Problematic Spitzoid Melanocytic Lesions: A Report on 18 Patients. Cancer, 97, 499-507. http://dx.doi.org/10.1002/cncr.11074
Smith, K.J., Barrett, T.L., Skelton III, H.G., Lupton, G.P. and Graham, J.H. (1989) Spindle Cell and Epithelioid Cell Nevi with Atypia and Metastasis (Malignant Spitz Nevus). American Journal of Surgical Pathology, 13, 931-939. http://dx.doi.org/10.1097/00000478-198911000-00003
Cerroni, L., Barnhill, R., Elder, D., Gottlieb, G., Heenan, P., Kutzner, H., et al. (2010) Melanocytic Tumors of Uncertain Malignant Potential: Results of a Tutorial Held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008. American Journal of Surgical Pathology, 34, 314-326. http://dx.doi.org/10.1097/PAS.0b013e3181cf7fa0
Hung, T., Piris, A., Lobo, A., Mihm Jr., M.C., Sober, A.J., Tsao, H., Tanabe, K.K. and Duncan, L.M. (2013) Sentinel Lymph Node Metastasis Is Not Predictive of Poor Outcome in Patients with Problematic Spitzoid Melanocytic Tumors. Human Pathology, 44, 87-94. http://dx.doi.org/10.1016/j.humpath.2012.04.019
Zuckerman, R., Maier, J.P., Guiney Jr., W.B., Huntsman, W.T. and Mooney, E.K. (2001) Pediatric Melanoma: Confirming the Diagnosis with Sentinel Node Biopsy. Annals of Plastic Surgery, 46, 394-399. http://dx.doi.org/10.1097/00000637-200104000-00007
Urso, C., Borgognoni, L., Doria, M., Tinacci, G. and Zini, E. (2009) Non-Sentinel Lymph Node Involvement in a Patient with an Atypical Spitz Tumor and a Positive Sentinel Node. Report of a Case and Review of the Literature. Journal of Cutaneous Pathology, 36, 586-590. http://dx.doi.org/10.1111/j.1600-0560.2008.01080.x
Wick, M.R. (2006) Melanocytic Lesions with Features of Spitz Nevus. Human Pathology, 37, 779-780. http://dx.doi.org/10.1016/j.humpath.2006.05.001
Maduekwe, U.N., Hornicek, F.J., Springfield, D.S., Raskin, K.A., Harmon, D.C., Choy, E., et al. (2009) Role of Sentinel Lymph Node Biopsy in the Staging of Synovial, Epithelioid, and Clear Cell Sarcomas. Annals of Surgical Oncology, 16, 1356-1363. http://dx.doi.org/10.1245/s10434-009-0393-9
Alcorn, K.M., Deans, K.J., Congeni, A., Sulkowski, J.P., Bagatell, R., Mattei, P. and Minneci, P.C. (2013) Sentinel Lymph Node Biopsy in Pediatric Soft Tissue Sarcoma Patients: Utility and Concordance with Imaging. Journal of Pediatric Surgery, 48, 1903-1906. http://dx.doi.org/10.1016/j.jpedsurg.2013.04.013
Andreou, D., Boldt, H., Werner, M., Hamann, C., Pink, D. and Tunn, P.U. (2013) Sentinel Node Biopsy in Soft Tissue Sarcoma Subtypes with a High Propensity for Regional Lymphatic Spread—Results of a Large Prospective Trial. Annals of Oncology, 24, 1400-1405. http://dx.doi.org/10.1093/annonc/mds650
Nishida, Y., Tsukushi, S., Yamada, Y., Shimoyama, Y., Shido, Y., Wasa, J. and Ishiguro, N. (2011) Recurrent Alveolar Rhabdomyosarcoma with Prior Surgery and Radiotherapy: Altered Lymphatic Drainage Limits the Reliability of Sentinel Lymph Node Biopsy. Journal of Pediatric Hematology/Oncology, 33, e26-e28. http://dx.doi.org/10.1097/MPH.0b013e3181faf857
Riad, S., Griffin, A.M., Liberman, B., Blackstein, M.E., Catton, C.N., Kandel, R.A., et al. (2004) Lymph Node Metastasis in Soft Tissue Sarcoma in an Extremity. Clinical Orthopaedics and Related Research, 426, 129-134. http://dx.doi.org/10.1097/01.blo.0000141660.05125.46
Behranwala, K.A., A’Hern, R., Omar, A.M. and Thomas, J.M. (2004) Prognosis of Lymph Node Metastasis in Soft Tissue Sarcoma. Annals of Surgical Oncology, 11, 714-719. http://dx.doi.org/10.1245/ASO.2004.04.027
Billingsley, K.G., Burt, M.E., Jara, E., Ginsberg, R.J., Woodruff, J.M., Leung, D.H. and Brennan, M.F. (1999) Pulmonary Metastases from Soft Tissue Sarcoma: Analysis of Patterns of Diseases and Postmetastasis Survival. Annals of Surgery, 229, 602-610. http://dx.doi.org/10.1097/00000658-199905000-00002
Fong, Y., Coit, D.G., Woodruff, J.M. and Brennan, M.F. (1993) Lymph Node Metastasis from Soft Tissue Sarcoma in Adults. Analysis of Data from a Prospective Database of 1772 Sarcoma Patients. Annals of Surgery, 217, 72-77. http://dx.doi.org/10.1097/00000658-199301000-00012
Daigeler, A., Kuhnen, C., Moritz, R., Stricker, I., Goertz, O., Tilkorn, D., et al. (2009) Lymph Node Metastases in Soft Tissue Sarcomas: A Single Center Analysis of 1,597 Patients. Langenbeck’s Archives of Surgery, 394, 321-329. http://dx.doi.org/10.1007/s00423-008-0371-x
Deenik, W., Mooi, W.J., Rutgers, E.J., Peterse, J.L., Hart, A.A. and Kroon, B.B. (1999) Clear Cell Sarcoma (Malignant Melanoma) of Soft Parts: A Clinicopathologic Study of 30 Cases. Cancer, 86, 969-975. http://dx.doi.org/10.1002/(SICI)1097-0142(19990915)86:6 3.0.CO;2-Z
Mcmulkin, H.M., Yanchar, N.L., Fernandez, C.V. and Giacomantonio, C. (2003) Sentinel Lymph Node Mapping and Biopsy: A Potentially Valuable Tool in the Management of Childhood Extremity Rhabdomyosarcoma. Pediatric Surgery International, 19, 453-456. http://dx.doi.org/10.1007/s00383-003-0956-y
National Cancer Institute at the National Institutes of Health. Childhood Rhabdomyosarcoma Treatment (PDQ®). http://www.cancer.gov
National Cancer Institute at the National Institutes of Health. Childhood Soft Tissue Sarcoma Treatment (PDQ®). http://www.cancer.gov
Flynn, L.W., Park, J., Patil, S.M., Cody III, H.S. and Port, E.R. (2008) Sentinel Lymph Node Biopsy Is Successful and Accurate in Male Breast Carcinoma. Journal of the American College of Surgeons, 206, 616-621. http://dx.doi.org/10.1016/j.jamcollsurg.2007.11.005
Pacella, S.J., Lowe, L., Bradford, C., Marcus, B.C., Johnson, T. and Rees, R. (2003) The Utility of Sentinel Lymph Node Biopsy in Head and Neck Melanoma in the Pediatric Population. Plastic & Reconstructive Surgery, 112, 1257-1265. http://dx.doi.org/10.1097/01.PRS.0000080728.51964.4A
Palmer 3rd, P.E., Warneke, C.L., Hayes-Jordan, A.A., Herzog, C.E., Hughes, D.P., Lally, K.P. and Austin, M.T. (2013) Complications in the Surgical Treatment of Pediatric Melanoma. Journal of Pediatric Surgery, 48, 1249-1253. http://dx.doi.org/10.1016/j.jpedsurg.2013.03.018