Successful Treatment of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto*
- 1 Department of Pediatrics, Tokyo Takanawa Hospital, Tokyo, Japan
- 2 Department of Pediatrics, Tokyo Takanawa Hospital, Tokyo, Japan
Abstract
Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30; Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.
- Marshall, G.S., Edwarde, K.M., Butler, J. and Lawton, A.R. (1987) Syndrome of Periodic Fever, Pharyngitis, and Aphthous Stomatitis. The Journal of Pediatrics, 110, 43-46. http://dx.doi.org/10.1016/S0022-3476(87)80285-8
- Abramson, J.S., Givner, L.B. and Thompson, J.N. (1989) Possible Role of Tonsillectomy and Adenoidectomy in Children with Recurrent Fever and Tonsillopharyngitis. The Pediatric Infectious Disease Journal, 8, 119-120.
- Renko, M., Salo, E., Putto-Lauria, A., Saxen, H., Mattila, P.S., Luotonen, J., Ruuskanen, O. and Uhari, M. (2007) A Randomized, Controlled Trial of Tonsillectomy in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. The Journal of Pediatrics, 151, 289-292. http://dx.doi.org/10.1016/j.jpeds.2007.03.015
- Victoria, M., Wurster, V.M., Carlucci, J.G., Feder, H.M. and Edwards, K.M. (2011) Long-Term Follow-Up of Children with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome. The Journal of Pediatrics, 159, 958-964. http://dx.doi.org/10.1016/j.jpeds.2011.06.004
- Garavello, W., Pignataro, L., Gaini, L., Torretta, S., Somigliana, E. and Gaini, R. (2011) Tonsillectomy in Children with Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. The Journal of Pediatrics, 159, 138-142. http://dx.doi.org/10.1016/j.jpeds.2010.12.014
- Stojanov, S., Hoffmann, F., Kery, A., Renner, E.D., Hartl, D., Lohse, P., Huss, K., Fraunberger, P., Malley, J.D., Zellerer, S., Albert, M.H. and Belohradsky, B.H. (2006) Cytokine Profile in PFAPA Syndrome Suggests Continuous Inflammation and Reduced Anti-Inflammatory Response. European Cytokine Network, 17, 90-97.
- Peridis, S., Koudoumnakis, E., Theodoridis, A., Stefanaki, K., Helmis, G. and Houlakis, M. (2010) Surgical Outcomes and Histology Findings after Tonsillectomy in Children with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome. American Journal of Otolaryngology, 31, 472-475. http://dx.doi.org/10.1016/j.amjoto.2009.06.005
- Yamaguchi, H. (2011) Pediatric Infectious Disease and Kampo. Imminent Kampo Treatment for Childhood Disease, 10, 103-117. (Japanese)
- Ishii, A. (2013) Experiences of Shinbuto (Zhen-Wu-Tang, Chinese Herbal Medicine) for Acute Infections in Children. Nihon Shoni Toyo Igakkaishi, 25, 90-97. (Japanese with English Abstract)