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An Evans Syndrome Case Expressing Anti-Jk<sup>a</sup> Autoantibody under Condition of Primary IgA Immunodeficiency
Department of Hematology and Oncology, Kita-Harima Medical Center, Ono, Japan
Institute of Biomedical Research and Innovation, Kobe, Japan
Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 1 Department of Hematology and Oncology, Kita-Harima Medical Center, Ono, Japan
- 2 Institute of Biomedical Research and Innovation, Kobe, Japan
- 3 Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
- 4 Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
- 5 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 6 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 7 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 8 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 9 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 10 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
- 11 Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan
- 12 Department of Pediatric Medicine, Kobe University Hospital, Kobe, Japan
International Journal of Clinical Medicine·Volume 06 (2015)·Pages 496–499·Published 1 July 2015·DOI10.4236/ijcm.2015.67066
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Abstract
Autoimmune haemolytic anaemia is a haemolytic disease resulting from an autoimmune reaction to the surface of red blood cells. A part of autoantibody is known to react with the blood type antigen. This is the case of a 14 years old female with Evans syndrome in which autoimmune haemolysis may cause from anti-Jk a autoantibody reaction. As this case is complicated with primary IgA immunodeficiency syndrome, anti-Jk a autoantibody may occur under the condition of primary immunodeficiency status, in which autoantibody production is accelerated. Considering the co-occurrence of autoimmune haemolytic anaemia and primary IgA immunodeficiency syndrome, analysis focusing on specificity for red blood cells antigens will be required in IgA immunodefi-ciency syndrome patients.
KeywordsAnti-Jk<sup>a</sup>AutoantibodyEvans SyndromeIgA Immunodeficiency
- Klein, H.G. and Anstee, D.J. (2006) Mollison’s Blood Transfusion in Clinical Medicine. 11th Edition, Blackwell Publishing, Hoboken, 268.
- Reid, M.E., Lomas-Francis, C. and Olsson, M.L. (2012) The Blood Group Antigen Facts Book. 3rd Edition, Academic Press, Waltham, 378.
- Ciaffoni, S., Ferro, I., Potenza, R. and Campo, G. (1987) Evans Syndrome: A Case of Autoimmune Thrombocytopenia and Autoimmune Hemolytic Anemia Caused by Anti-Jka. Haematologica, 72, 245-247.
- Sander, R.P., Hardy, N.M. and Van Meter, S.A. (1987) Anti-Jka Autoimmune Hemolytic Anemia in an Infant. Transfusion, 27, 58-60. http://dx.doi.org/10.1046/j.1537-2995.1987.27187121475.x
- Ganly, P.S., Laffan, M.A., Owen, I. and Hows, J.M. (1988) Auto-Anti-Jka in Evans’ Syndrome with Negative Direct Antiglobulin Test. British Journal of Haematology, 69, 537-539. http://dx.doi.org/10.1111/j.1365-2141.1988.tb02411.x
- Wernli, R.Y., Strauss, R.G. and Cordle, D.G. (1990) A Patient with Transient Autoanti-Jka. Acta Haematologica, 84, 190-192. http://dx.doi.org/10.1159/000205061
- Grishaber, J.E., Cordle, D.G. and Strauss, R.G. (1992) Development of Alloanti-Jka in a Patient with Hemolytic Anemia Due to Autoanti-Jkb. American Journal of Clinical Pathology, 98, 542-544.
- Guastafierro, S., Sessa, F., Cuomo, C. and Tirelli, A. (2004) Delayed Hemolytic Transfusion Reaction Due to Anti-S Antibody in Patient with Anti-Jk(a) Autoantibody and Multiple Alloantibodies. Annals of Hematology, 83, 307-308. http://dx.doi.org/10.1007/s00277-003-0794-y
- Wondergem, M.J., Overbeeke, M., Som, N., Chamuleau, M.E., Jonkhoff, A.R. and Zweegman, S. (2006) Mixed Autoimmune Haemolysis in a SLE Patient Due to Aspecific and Anti-Jka Autoantibodies; Case Report and Review of the Literature. Haematologica, 91, ECR12.
- Garcia-Munoz, R., Anton, J., Rodriguez-Otero, P., Moreno, C., Sanchez-Ibarrola, A., Seijo, L.M. and Paramo, J.A. (2008) Common Variable Immunodeficiency and Evans Syndrome Complicated by Autoimmune Hemolysis Due to Anti-Jka Auto-Antibodies. Leukemia Lymphoma, 49, 1220-1222. http://dx.doi.org/10.1080/10428190801993488
- Giovannetti, G., Pauselli, S., Barrella, G., Neri, A., Antonetti, L., Gentile, G., Iacobini, M., Girelli, G. and Coluzzi, S. (2013) Severe Warm Autoimmune Haemolytic Anaemia Due to Anti-Jk(a) Autoantibody Associated with Parvovirus B19 Infection in a Child. Blood Transfusion, 11, 634-635.
- Arason, G.J., Jorgensen, G.H. and Ludviksson, B.R. (2010) Primary Immunodeficiency and Autoimmunity: Lessons from Human Diseases. Scandinavian Journal of Immunology, 71, 317-328. http://dx.doi.org/10.1111/j.1365-3083.2010.02386.x