The Effect of Pomegranate Paste on Neonatal Jaundice Incidence: A Clinical Trial in Women during Pregnancy
- 1 Department of Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Iran
- 2 Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Ardakan, Iran
- 3 Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
- 4 Department of Biostatistics & Epidemiology, Health Faculty, Shahid Sadoughi University of Medical Sciences, Ardakan, Iran
- 5 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- 6 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Purpose: Some topics such as women’s life style and nutrition and using some special medicines during pregnancy have been discussed and demonstrated as effective factors on infant’ health. Based on recommendations in Iranian traditional medicine, we aimed to evaluate the efficacy of pomegranate paste consumed by women during their pregnancy on the neonatal jaundice incidence. Methods: In this single-blinded controlled clinical trial, 80 healthy pregnant women were randomly divided into 2 groups, as treatment and control. The treatment group members added pomegranate paste to their daily diet from the 34 th week of the pregnancy to birth, as administered. The levels of neonates’ bilirubin were checked in the 5 th day of the delivery. Results: Both the need of phototherapy and the mean level of neonates’ bilirubin in the group fed with pomegranate paste were significantly lesser compared to control group. The number of neonates who were undergone phototherapy in the pomegranate paste receiving group was significantly lesser than that in the control group ( P value = 0.029). By measuring the total bilirubin, statically significant difference between the treatment group and the control group was seen ( P value = 0.021). Conclusion: The results of this study suggest the possible effect of adding pomegranate paste to pregnant women’s diet on the incidence of neonatal jaundice.
- Stoll, B. and Kliegman, R. (2008) Jaundice and Hyperbilirubinemia in the Newborn. In: Behemen, R., Kliegman, R. and Jenson, H., Eds., Nelson Textbook of Pediatrics, 18th Edition, Saunders, Philadelphia, 756-765.
- Azadbakht, M., Pishva, N., Mohammadi Samani, S. and Alinejad, F. (2005) The Effect of Purgative Manna on the Infant Jaundice. Iranian Journal of Pharmaceutical Sciences, 1, 95-100.
- Ambalavanan, N. and Carloa, W.A. (2015) Kernicterus. In: Kliegman, R.M., Stanton, B.F., Schor, N.F. and St Geme, J.W., Eds., Nelson Textbook of Peadiatrics, 20th Edition, Elseviers, New Delhi, 876.
- Bhutani, V.K., Poland, R., Meloy, L.D., Hegyi, T., Fanaroff, A.A. and Maisels, M.J. (2016) Clinical Trial of Tin Mesoporphyrin to Prevent Neonatal Hyperbilirubinemia. Journal of Perinatology, 36, 533-539. https://doi.org/10.1038/jp.2016.22
- Davies, G.A., Maxwell, C., McLeod, L., et al. (2010) Obesity in Pregnancy. International Journal of Gynecology & Obstetrics, 110, 167-173. https://doi.org/10.1016/j.ijgo.2010.03.008
- Basiri-Moghadam, M., Basiri-Moghadam, K., Kianmehr, M. and Jani, S. (2015) The Effect of Massage on Neonatal Jaundice in Stable Preterm Newborn Infants: A Randomized Controlled Trial. Journal of Pakistan Medical Association, 65, 602-606.
- Fok, T.F. (2001) Neonatal Jaundice-Traditional Chinese Medicine Approach. Journal of Perinatology, 21, S98-S100. https://doi.org/10.1038/sj.jp.7210643
- Ebrahimimd, S., Ashkani-Esfahani, S. and Poormahmudibs, A. (2011) Investigating the Efficacy of Zizyphus jujuba on Neonatal Jaundice. Iranian Journal of Pediatrics, 21, 320-324.
- Dennery, P.A. (2002) Pharmacological Interventions for the Treatment of Neonatal Jaundice. Seminars in Neonatology, 7, 111-119. https://doi.org/10.1053/siny.2002.0098
- Aghili Khorasani, M.H. (2001) Makhzanul-Advieh (Encyclopedia of Ancient medical Drugs). Choogan, Tehran.
- Kermani, N.A. (2008) Sharhol-Asbab val Alamat. Almoa, Tehran.
- Hosseini, M.M. (1979) Tohfeye Hakim Momen. Mahmoudi, Tehran.
- Ernst, E. (2002) Herbal Medicinal Products during Pregnancy: Are They Safe? BJOG, 109, 227-235. https://doi.org/10.1111/j.1471-0528.2002.t01-1-01009.x
- Montvale, J., Brendler, T. and Jaenicke, C. (2000) PDR for Herbal Medicines. Medical Economics Company, Montvale.