A Prognostic Model of the Development of Postpartum Purulent-Inflammatory Diseases
- 1 Department of Obstetrics and Gynaecology, Pirogov Vinnytsia National Medical University of the Ministry of Health of Ukraine, Vinnytsia, Ukraine
- 2 Lviv Regional Public Health Centre, Lviv, Ukraine
- 3 Ivan Franko National University of Lviv, Lviv, Ukraine
- 4 University of Leicester, Leicester, UK
- 5 University of Leicester, Leicester, UK
- 6 University of Leicester, Leicester, UK
Abstract
Background: Currently, postpartum purulent-inflammatory diseases continue to be a prominent issue in medicine. As a result, numerous scientific publications were devoted to finding the solution to this issue. Primarily these solutions included the idea of optimisation of antibiotic-based disease prevention and therapies. However, the early diagnosis and prognosis of these pathologies were unfortunately overlooked. The Aim of the Study: To build a prognostic model of the development of postpartum purulent-inflammatory diseases. Material and Methods: The main focus of our research was establishment of methods of early diagnosis and prognosis of purulent-inflammatory diseases. The main cohort consisted of 170 women diagnosed with purulent-inflammatory diseases while the control cohort was made of 40 women with an uncomplicated course of pregnancy; patient’s blood serum was analysed using fluorescence spectroscopy. Additionally, we implied a variety of standardised algorithms used during clinical and laboratory examination of the patients with postpartum endometritis. Results: Fluorescence spectra were studied for 40 women of control group and 170 women of the main group. Based on the data obtained using fluorescence spectroscopy and data from clinical and laboratory examinations (extragenital pathology, gynecology-related diseases, risk of miscarriage, surgery, TORCH-infections, colpitis, labour duration > 12 hrs, labour anomalies, maximum blood serum fluorescence spectrum values, fluorescence spectrum ≤ 0.845, age, number of bed days, fetal distress), we have derived a prognostic model of the development of postpartum purulent-inflammatory diseases. Conclusion: As a result, we derived a prognostic model based on the main 13 factors, which contribute to development of postpartum purulent-inflammatory diseases. This model was determined correct with a probability of over 99% (р < 0.001; χ 2 = 174.74; df = 13).
- Serov, V.N. (2011) Maternal Mortality Prevention. Obstetrics and Gynaecology, 7, 4-10.
- Ostapiuk, L. (2019) Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases. International Journal of Clinical Medicine, 10, 577-595. https://doi.org/10.4236/ijcm.2019.1011047
- Zaporozhan, V.P., Myshchenko, V.P. and Rudenko, I.V. (2012) Prevention of Placental Dysfunction from the Perspective of the Individual Characteristics of the Woman’s Body. The Journal Women’s Health, 9, 114-117.
- Dior, U.P. and Kogan, L. (2014) Leukocyte Blood Count during Early Puerperium and Its Relation to Puerperal Infection. The Journal of Maternal-Fetal & Neonatal Medicine, 27, 18-23. https://doi.org/10.3109/14767058.2013.799653
- Bays, H.E., Stein, E.A. and Shah, A.K. (2002) Effects of Simvastatin on C-Reactive Protein in Mixed Hyperlipidemic and Hypertriglyceridemic Patients. American Journal of Cardiology, 90, 942-946. https://doi.org/10.1016/S0002-9149(02)02658-9
- Tujula, B., Kokki, H., Rasanen, G. and Kokki, М. (2018) Procalcitonin; a Feasible Biomarker for Severe Bacterial Infections in Obstetrics and Gynecology? Acta Obstetricia et Gynecologica Scandinavica, 97, 505-506. https://doi.org/10.1111/aogs.13346
- Paccolat, C., Harbarth, S., Courvoisier, D., Irion, O. and de Tejada, B.M. (2011) Procalcitonin Levels during Pregnancy. Delivery and Postpartum. Journal of Perinatal Medicine, 39, 679-683. https://doi.org/10.1515/jpm.2011.082
- Nasonova, D.M., Karymova, J.H., Yvanets, T.U. and Shmakov, R.H. (2018) A Method for Predicting Postpartum Endometritis Using an Indicator of the Detoxification Efficiency of Albumin. Patent of the Russian Federation.
- Andreeva, O.L. (2003) Change in the Binding Centers of Serum Albumin in Assessing the State of the Body in Various Pathologies. Thesis.
- Bulavenko, O., Ostapiuk, L., Rud, V., Voloshinovskii, A.S. and Маlui, T.S. (2019) Method of Early Diagnosis of Postpartum Purulent-Septic Complications Using the Method of Fluorescence Spectroscopy. Applicant and Patentee: National Pirogov Memorial Medical University.
- Herych, I.D., Bulavenko, O.V., Ostapiuk, L.R., Voloshinovskii, A.S. and Myagkota, S.V. (2013) Method for Early Diagnosis of Septic Complications by the Method of Fluorescence Spectroscopy. Applicant and Patentee: National Pirogov Memorial Medical University.
- Bulavenko, O.V., Ostapiuk, L.R., Rud, V.O., Voloshinovskii, A.S., Маlui, T.S. and Rud, O.V. (2017) A New View on the Diagnosis of Purulent-Inflammatory Diseases after Childbirth. The Journal Women’s Health, 9, 22-26.