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Synthesis of Some New Bispyrazolidine Derivatives for Biological Interest
College of Pharmacy, University of Florida, USA
Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
- 1 College of Pharmacy, University of Florida, USA
- 2 Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
International Journal of Organic Chemistry·Volume 10 (2020)·Pages 104–110·Published 29 April 2020·DOI10.4236/ijoc.2020.102007
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Abstract
One pot criss-cross cycloaddition reaction of substituted 2,3-diaz-1,3-butadienes ( 1 ) and/or ( 2 ) with two equivalents of 2,3-dichloro-1,4-naphthoquinone in presence of dry benzene afforded bisnaphth[2,3-c]pyrazolidinetetrone derivatives ( 3 ) & ( 4 ). The chemical structure was achieved by elemental and spectral analysis. Biological activity of the synthesized compounds was tested against some micro-organisms, and has shown an interesting fungicidal activity and strongly to remarkable bactericidal activity.
KeywordsBispyrazolidineCycloadditionAntimicrobial Activity
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